Luis Issolio

Optical quality of foldable monofocal intraocular lenses before and after injection: Comparative evaluation using a double-pass system

PURPOSE: To use the double‐pass technique to evaluate the in vitro optical quality of foldable monofocal intraocular lenses (IOLs) used to correct aphakia. SETTING: Universitat Politècnica de Catalunya, Terrassa, and Instituto de Microcirugía Ocular de Barcelona, Barcelona, Spain; Universidad Nacional de Tucumán, Tucumán, Argentina. METHODS: This study assessed the in vitro optical quality of 7 IOLs before and after injection in an artificial eye that was attached to a double‐pass system (Optical Quality Analysis System [OQAS]). The procedure imitated the conventional in vivo technique used to assess the optical quality of eyes with an IOL. The following parameters were evaluated: point‐spread function, modulation transfer function (MTF), MTF cutoff frequency, Strehl ratio, and OQAS values. RESULTS: The in vitro optical quality of most IOLs was as good after injection as before injection. In 1 IOL, the post‐injection optical quality was statistically significantly different but the optical quality remained high. CONCLUSIONS: Results indicate that after an IOL is placed in the eye, its optical performance will be good, providing good visual quality. The eye cell model attached to the double‐pass system was useful and effective for fully characterizing the optical quality of IOLs and evaluating variations resulting from the injection process.

Effect of brief exposure to glare on brightness perception in the scotopic-mesopic range

This paper reports a study of the effect of disability glare in the scotopic-mesopic range when there is brief exposure to glare to provide conditions similar to those encountered in night driving. Subjects compare the brightness of two uniform luminance fields that are displayed sequentially, when one of them is presented under glare conditions. The observers report which field is brighter. A forced-choice paradigm using the method of constant stimuli is used to determine the luminance corresponding to the perceptual matching luminance. Results show a non-linear relation of the glare illuminance to the matching luminance and a non-significant dependence on the luminance reference. The experimental data closely fit an equation taken from previous studies on the effect of a peripheral glare source upon the apparent brightness of an object. The relation between matching luminance and reference luminance could be an easy way to measurement the effect of glare.

Temporal retinal sensitivity in mesopic adaptation

Citation information: Matesanz BM, Issolio L, Arranz I, de la Rosa C, Menéndez JA, Mar S & Aparicio JA. Temporal retinal sensitivity in mesopic adaptation. Ophthalmic Physiol Opt 2011, 31, 615–624. doi: 10.1111/j.1475‐1313.2011.00859.x

Brightness for different surround conditions : The effect of transient glare

We measured the effect of a transient glare source on the perceived brightness of a standard luminance (LSTD) patch (0.5 cd/m2) as a function of the surround luminance (LS). In the experiment, both increment and decrement stimuli were dependent on the value of the LS (0.01, 0.2, 0.4, 0.6, 0.8, 1.0, 1.5, or 2.0 cd/m2). We adopted a magnitude comparison paradigm using constant stimuli to determine the test matching luminance (LM). When Ls was lower than the luminance of the patch, which corresponds to increments, LM was lower than LSTD, and this effect was highest for the lowest LS. There was a small but noticeable cusp as increments shifted to decrements. As Ls increased further (i.e., as the decrement grew), LM flattened out below LSTD. The overall pattern of results could be interpreted in terms of the concept ofcontrast brightness, with consideration of the intrinsic differences in brightness evaluations between decrements and increments.

Comparison between an objective and a psychophysical method for the evaluation of intraocular light scattering

In this study we present the comparison of the performance of two systems to measure intraocular scattering. Measurements were made by using a psychophysical system based on a brightness comparison method that provides a glare index and a physical system based on the double-pass technique, which gives an objective scatter index by measuring the optical quality of the eye. Three external diffuser filters that simulated different grades of intraocular scattering were used in subjects with normal vision. The two measured indexes showed a graded rise with increasing level of scattering. The discrimination ability obtained for both systems showed that they were able to distinguish among conditions ranging from normal to early cataracts.

Quantitative and functional influence of surround luminance on the letter contrast sensitivity function.

Aim:  To determine the influence of surround luminance on the letter contrast sensitivity function.

Time course of brightness under transient glare condition

It was shown that a peripheral glare source reduces the brightness of a foveal stimulus. We hypothesized that this brightness reduction is governed by an inhibitory effect of the glare source on the test. We reported the results of an investigation of the dynamic of brightness reduction of an incremental stimulus immediately after the onset of a glare source in the field of view. A magnitude comparison paradigm using constant stimuli was adopted to determine the luminance that appeared equal in brightness to the standard patch. The luminance of the standard stimulus was in the mesopic range (0.5 cd/m2), and the levels of glare were 15 and 60 lx. Results showed that the time course of brightness reduction followed the typical shape attributed to the Broca-Sulzer effect. Data were fitted with a model that first considers the response of a peripheral ganglion cell to glare and then its inhibitory effect on the test signals. We discussed the plausibility of a postretinal stage of processing.

Straylight and Visual Quality on Early Nuclear and Posterior Subcapsular Cataracts

ABSTRACT Purpose: To measure log(s) and OSI parameters, both related to forward light scattering in the eye, in subjects with different kinds of early cataracts—nuclear or posterior subcapsular—and corrected visual acuity (CVA). Methods: 34 eyes of 19 patients ranged between 50 and 75 years old with diagnosed nuclear (14 eyes) or posterior subcapsular cataract (20 eyes) were recruited. Only NO1, NO2, P1, and P2 opacity scores according to LOCS III were included. Observer examination included visual acuity, contrast threshold (Ct), and measurements performed by straylightmeter (straylight parameter log(s)) and double-pass instrument (objective scatter index (OSI)). Results: OSI and log(s) were correlated with LOCSIII in nuclear opacities (p = 0.015 and 0.004, respectively) and in the whole data (p = 0.027 and 0.019, respectively) but did not for posterior subcapsular opacities alone. OSI was strongly correlated with log(s) in nuclear (r = 0.885 and p < 0.001) but not in posterior subcapsular cases (r = 0.382 and p = 0.097). Ct was correlated with log(s) for both cataract types (p = 0.043 for nuclear and p= 0.005 for posterior subcapsular cataract) but not with OSI (p = 0.093 for nuclear and p = 0.064 for posterior subcapsular cataract). Conclusions: OSI and log(s) discriminate early stages of nuclear cataracts when taking LOCS III as reference, so these opacities could be graded by any of those parameters. LOCSIII does not represent the visual condition for posterior subcapsular cataract. Straylightmeter measurements express the loss in contrast sensitivity caused by nuclear and posterior subcapsular opacities. Studies of lens opacities must be separated according to the type of opacity present in eyes.

Discrimination between Surgical and Nonsurgical Nuclear Cataracts Based on ROC Analysis

Abstract Purpose: The aim of this article is to propose a quantitative methodology for determining a criterion to discriminate the nonsurgical nuclear cataract from the surgical one taking into account objective measures of intraocular scattering in patients with good visual acuity (>0.6). Methods: Two groups of subjects were taken into account: a control group and a group with nuclear cataracts. At a first stage, eyes belonging to the cataract group were classified into “nonsurgical” and “surgical” cataracts by ophthalmologists at their clinical settings. At a second stage a double-pass instrument was also used to determine the objective scatter index (OSI) at the laboratory. Receiver operating characteristic (ROC) curves were used to analyze OSI values to determine a value able to separate between nonsurgical and surgical cataracts. Results: We obtained statistically significant differences among the control and both nuclear cataract groups (p < 0.05). ROC curves determined an OSI criterion level (of 2.1) to suggest surgery in nuclear cataracts with an area under curve of 0.83, i.e. with 80% of sensitivity and 80% of specificity. Conclusions: ROC analysis allows separating both groups of nuclear cataract, and we determined a value of OSI in nuclear cataract quantification for surgery.

Veiling luminance as a descriptor of brightness reduction caused by transient glare.

The presence of a glare source in the visual field produces a veiling luminance (L(v)), which generates a brightness reduction that can be expressed in terms of the glare index (V). The relation between the veiling luminance caused by glare and the apparent brightness reduction of a reference target has already been established for steady conditions. In this paper, the relationship is derived for transient glare. First, the relation is tested empirically, and then previous results concerning the effect of transient glare on brightness are summarized and analyzed. From this analysis, a power function relation between L(v) and V is encountered.