Luis Maranga
MedImmune
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Publication
Featured researches published by Luis Maranga.
Vaccine | 2011
Kunal Aggarwal; Frank Jing; Luis Maranga; Jonathan Liu
Uncertainties and shortcomings associated with the current influenza vaccine production processes demand attention and exploration of new vaccine manufacture technologies. Based on a newly developed mammalian cell culture-based production process we investigated selected process parameters and describe three factors that are shown to impact productivity, process robustness and development time. They are time of infection, harvest time and virus input, or multiplicity of infection (MOI). By defining the time of infection as 4-5 days post cell seeding and harvest time as 2-3 days post-infection and comparing their effect on virus production, MOI is subsequently identified as the most impactful process parameter for live attenuated influenza vaccine (LAIV) manufacture. Infection at very low MOI (between 10(-4) and 10(-6) FFU/cell) resulted in high titer virus production (up to 30-fold productivity improvement) compared to higher MOI infections (10(-3) to 10(-2) FFU/cell). Application of these findings has allowed us to develop a platform process that can reduce the development time to approximately three weeks for an influenza vaccine manufacture process for new strains.
Biotechnology and Bioengineering | 2010
Meena George; Masiha Farooq; Thi Dang; Bernadette Cortes; Jonathan Liu; Luis Maranga
Archive | 2009
Jonathan Liu; Mark Thompson; Luis Maranga; Floro Cataniag; Simon Hsu
Archive | 2007
Jonathan Liu; Richard Schwartz; Mark Thompson; Luis Maranga; Simon Hsu; Mridul Ghosh; Ajit Subramanian
Archive | 2010
Jonathan Liu; Richard B. Schwartz; Mark Thompson; Luis Maranga; Simon Hsu; Mridul Ghosh; Ajit Subramanian
Archive | 2007
Jonathan Liu; Richard Schwartz; Mark Thompson; Luis Maranga; Simon Hsu; Mridul Ghosh; Ajit Subramanian
Archive | 2015
Liu Jonathan; Thompson Mark; Luis Maranga; Floro Cataniag; Hsu Simon S
Archive | 2009
Jonathan Liu; Mark Thompson; Luis Maranga; Floro Cataniag; Simon Hsu
Archive | 2008
Jonathan Liu; Luis Maranga; Sachin Mani; Richard B. Schwartz
Archive | 2007
Jonathan Liu; Richard B. Schwartz; Mark Thompson; Luis Maranga; Simon Hsu; Mridul Ghosh; Ajit Subramanian