Luisa Morell-Quadreny
University of Valencia
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Luisa Morell-Quadreny.
Virchows Archiv | 2001
Alina Romanenko; Luisa Morell-Quadreny; V. Nepomnyaschy; Alexander Vozianov; Antonio Llombart-Bosch
Abstract. After the Chernobyl accident, the morbidity of renal-cell carcinomas in Ukraine increased gradually from 4.7 to 7.5 per 100,000 of the total population. Cesium 137 (137Cs) is responsible for 80–90% of the internal radioactivity in people living in radiocontaminated areas of Ukraine, and 90% of 137Cs is eliminated through the kidneys. Histological and immunohistochemical study of proliferating cell nuclear antigen (PCNA) and K-ras protein was performed in peritumoral kidney tissues of 167 Ukrainian patients (groups I–III, according to varying degrees of internal exposure to radiation), and of 85 analog Spanish patients, as a control group. Our data showed in the majority of Ukrainian patients a radiation sclerosing proliferative atypical nephropathy (RSPAN) in association with an increase in the incidences of tubular epithelial nuclear atypia and carcinoma in situ (CIS). Areas of epithelial nuclear atypia and CIS of the cortex and medulla showed significant PCNA expression with means of extent as 12, 14, and 15% of stained nuclei in groups I, II, and III respectively. K-ras expression of the same areas occurred in 67, 87, and 85% of cases in groups I, II, and III respectively. The present study points to a strong relationship between the long term of low-dose radiation exposure of the Ukrainian population and the development of RSPAN as a possible precursor of malignancy. In addition, it confirms the possible initiator, promoter, or progressor role of chronic low-level radiation of renal human carcinogenesis in Ukraine.
Virchows Archiv | 2004
Alina Romanenko; Luisa Morell-Quadreny; José Antonio López-Guerrero; Antonio Pellín; Valentin Nepomnyaschy; Alexander Vozianov; Antonio Llombart-Bosch
Previous studies have shown that during the period subsequent to the Chernobyl accident, increases in morbidity, aggressivity and proliferative activity of renal-cell carcinomas (RCCs) in Ukrainian patients were recognized. The present paper describes the molecular alterations of those tumor suppressor genes located on chromosome 9p21 (INK4a/ARF locus and p15INK4B) in 26 primary renal-cell epithelial tumors from patients with different degrees of radiation exposure after the Chernobyl accident in Ukraine. Radiometric measurement of Cesium 137 (137Cs) was conducted with 1-day urine from all patients before surgery. Our results demonstrate that RCCs from patients living in the radio-contaminated areas showed aberrant hypermethylation of p14ARF and p16INK4A genes, associated with increased p38MAPK, p14ARF, mdm2, cyclinD1 and Ki67 protein expression levels. Present findings show the possibility that chronic long-term low-dose radiation activates the INK4a/ARF locus, targeted by activation of the p38MAPK cascade. These actions could lead to disruptions and loss of cell cycle checkpoints and, thereby, to cellular transformation.
Cancer Genetics and Cytogenetics | 1996
M. Aurelia Gregori-Romero; Luisa Morell-Quadreny; Antonio Llombart-Bosch
Cytogenetic analysis of a human renal oncocytoma revealed a near-haploid chromosome number of 36 with the loss of chromosomes 1, 2, 3, 6, 8, 9, 15, 17, 21, and 22. Review of the literature disclosed that this cytogenetic configuration is extremely rare in solid human tumors and that no renal oncocytomas with near-haploid stemline karyotype have been described. These results are compared with the other published cases of oncocytoma.
Virchows Archiv | 2007
Alina Romanenko; Luisa Morell-Quadreny; David Ramos; Valentin Nepomnyaschiy; Alexander Vozianov; Antonio Llombart-Bosch
The Chernobyl accident introduced for the first time the problem of chronic, persistent, long-term, low-dose exposure to ionizing radiation (IR) in humans. Currently, 21 years after the accident at the Chernobyl Power Plant in Ukraine (70 Km from Kiev), approximately 17 million people live in the radiocontaminated area and have been exposed to lowdose IR. Information regarding irradiation of the Ukrainian population is based on the official reports provided by the UkrainianGovernment and theUkrainian Academy ofMedical Sciences. Morbidity of malignant renal tumors in adults during the period 1986–2006 increased from 4.7 to 9.9 per 100,000 of total population (from 6.0 to 12.6 per 100,000 of the male population and from 3.6 to 7.5 per 100,000 of the female population in Ukraine) [4]. The scientific collaboration between the Institute of Urology, the Academy of Medical Sciences in Kiev (Ukraine) and the Department of Pathology of the Valencia University in Spain has been in operation for approximately 9 years already. Recent studies by our group have shown that during the period subsequent to the Chernobyl accident, increases in morbidity, aggressivity, and proliferative activity of renalcell carcinomas (RCCs) in Ukrainian patients were recognized [2]. At the beginning of our study, we did separate patients with RCCs from the city of Kiev and patients with RCCs from radiocontaminated areas. Our recent studies have shown that RCCs (their histological and molecular biological features) of both these groups were identical (it is therefore not necessary to distinguish them); however, they significantly differ from the analogous tumors from clean (without radio-contamination) areas of Ukraine as well as the Spanish RCCs. It must be noted that the tumors (RCCs) were randomly selected (successive cases) from the laboratories of Kiev and Valencia. No one doubts the spontaneous origin of these RCCs in both geographical areas. The main differences are not in reference to their origin but to their biological, histological, and clinical behavior, which is clearly more aggressive in the Ukrainian population in comparison with the Valencian cases. Furthermore, “chronic low-dose irradiation toxicity” (CLDIT) exerts its effect as a cocarcinogen or within a pluri-carcinogenetic context. We have never proposed that CLDIT was the only cause of this cancer. The development of “radiation sclerosing proliferative atypical nephropathy” in the peritumoral kidney tissue then followed and demonstrated a good correlation with the duration of radiation exposure [3]. In addition, the influence of chronic, regular, and sustained low-dose IR on renal carcinogenesis in the population living in Cesium 137-contaminated areas of Ukraine has been confirmed [2]. Virchows Arch (2007) 451:107–108 DOI 10.1007/s00428-007-0442-3
International Journal of Surgical Pathology | 1996
Luisa Morell-Quadreny; M. Aurelia Gregori-Romero; Carmen Carda-Batalla; Antonio Llombart-Bosch
Eight conventional and six atypical oncocytomas in a series of 147 renal neoplasms were studied. Histopathologic findings revealed exclusively oncocytic cells, but cellular polymorphism was higher in the atypical tumors. Atypical oncocytomas presented focal necrosis, transcapsular invasion, or both. Electron microscopy showed similar findings in all cases. Immunohistochemistry of atypical oncocytomas had higher expression against proliferating cell nuclear antigen and more discontinuous immunostaining against laminin than typical ones. Flow cytometry revealed one or two aneuploid peaks in five typical and two atypical cases, although the latter had a higher proliferative fraction than typical oncocytomas. Cytogenetics of one typical oncocytoma showed a normal diploid karyotype; one atypical case resulted in a diploid karyotype but with endoreduplications in 13% of metaphases, and a second atypical oncocytoma became hypodiploid without structural anomalies. Based on the present results, the proposed distinction between conventional and atypical oncocytomas seems of limited clinical significance.
Genes, Chromosomes and Cancer | 1996
M. Aurelia Gregori-Romero; Luisa Morell-Quadreny; Antonio Llombart-Bosch
Virchows Archiv | 2006
Alina Romanenko; Luisa Morell-Quadreny; David Ramos; Valentin Nepomnyaschiy; Alexander Vozianov; Antonio Llombart-Bosch
Anticancer Research | 2003
Luisa Morell-Quadreny; Jose Rubio; José Antonio López-Guerrero; Juan Casanova; David Ramos; I. Iborra; Eduardo Solsona; Antonio Llombart-Bosch
Virchows Archiv | 2012
Alina Romanenko; Amparo Ruiz-Sauri; Luisa Morell-Quadreny; G. Valencia; Alexander Vozianov; Antonio Llombart-Bosch
Virchows Archiv | 2011
Luisa Morell-Quadreny; Alina Romanenko; José Antonio López-Guerrero; Silvia Calabuig; Alexander Vozianov; Antonio Llombart-Bosch