Luiz Paulo Sales Silva

CHAPTER 10:Scale‐up of Extraction Processes

The challenge of finding scale‐up criteria that allow the reproduction of laboratory data at higher scales is discussed in this chapter. The main factors that should be considered when scaling‐up extraction processes will be presented, and the nature of thermodynamic and mass transfer changes implied by scale‐up will be extensively discussed. The chapter contains an overview of the latest developments and applications in the field of natural products. Some simple examples of application of scale‐up criteria are shown. Moreover, a case study will present experimental data of a scale‐up procedure of supercritical fluid extraction from laboratory to pilot scale.