Lukman Makmur

Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)

Several species of the genus Artocarpus (Moraceae) have been investigated in our laboratories during the last decade. Over 60 phenolic constituents have been discovered and characterized, including 27 new compounds from 13 Indonesian taxa of Artocarpus, namely A. champeden, A. lanceifolius, A. teysmanii, A. scortechinii, A. rotunda, A. maingayi, A. kemando, A. bracteata, A. altilis, A. fretessi, A. gomezianus, A. reticulatus and A. glaucus. The principal and the most pronounced features of these phenolic constituents are the assembly of an isoprenyl substituent at C-3 of a flavone skeleton by closure of an ether bridge or a carbon-carbon linkage with the B ring of the skeleton, which may further rearrange into xanthone to produce various classes of natural products. The structures of the new and unusual natural products are presented. Many of the metabolites also exhibit cytotoxic effect against murine leukemia P388 cells.

Artoindonesianins G-I, three new isoprenylated flavones from Artocarpus lanceifolius

Three new isoprenylated flavones, artoindonesianins G-I (1-3), together with the two known flavones artelastofuran (4) and artelasticin (5), have been isolated from the heartwood of Artocarpus lanceifoliu. The structures of the new compounds were determined on the basis of spectroscopic data. Compounds 1-3 and 5 showed strong cytotoxicity against P-388 cells.

Andalasin A, a new stilbene dimer from Morus macroura.

A new stilbene dimer, andalasin A (1), together with the known stilbene oxyresveratrol and the 2-arylbenzofuran glycoside mulberroside C, have been isolated from the wood of Morus macroura. The structure of the new compound was elucidated on the basis of spectroscopic data. Compound 1 shows weak antinematodal and moderate antifungal properties.

A sesquiterpene alcohol from Litsea amara

Abstract A new tricyclic sesquiterpene alcohol was isolated from Litsea amara . The structure was deduced from spectroscopic analysis. The new sesquiterpene, which has been named indonesiol, has a seco -ishwarane skeleton.

Artoindonesianins Q-T, four isoprenylated flavones from Artocarpus champeden Spreng. (Moraceae).

Four isoprenylated flavones, artoindonesianins Q-T, were isolated from the heartwood of Artocarpus champeden Roxb. The structures of these compounds were elucidated on the basis of their spectroscopic data.

A stilbene dimer, andalasin B, from the root trunk of Morus macroura

A new stilbene dimer, andalasin B, was isolated from the root trunk of Morus macroura Miq., together with three known compounds, andalasin A, lunularin, oxyresveratrol, and β-resorcylaldehyde.

Regioselective glucosylation of oxyresveratrol by cell suspension cultures of Solanum mammosum

The glucosylation of oxyresveratrol by cell suspension cultures of Solanum mammosum has been investigated.

A new isoprenylated chalcone, artoindonesianin J, from the root and tree bark of Artocarpus bracteata

A new prenylated chalcone artoindonesianin J, the structure of which was determined on the basis of spectroscopic evidence, was isolated from the root and tree bark of Artocarpus bracteata Hook, together with three known flavonoids, kanzonol, 6-(3-methylbut-2-enyl)-apigenin and carpachromene.

Discovery of Natural Products from Indonesian Tropical Rainforest Plants: Chamodiversity of Artocarpus(Moraceae)

It is well known that Man has utilized the bioresources available in the environment for timber, food, clothes, fuel, and medicine. It is also well known that plants produce a bewildering array of natural chemicals many of which are used in modern health care. Consequently, many natural product chemicals produced by plants and microorganisms have been screened to identify compounds from which medicines for the treatment of malaria, cancer, AIDS, etc. might be developed.

ORGANIC CHEMISTRY OF NATURAL PRODUCTS IN INDONESIA OPPORTUNITY, ACHIEVEMENT AND CHALLENGES

Of the 250.000 species of higher plants known to exist on earth, 30.000 species are to be found in the tropical region of Indonesia. Many of these tropical plants have been employed as medicines by the indigeneous people in both rural and urban areas. However, only a relatively small amount of them have been thoroughly studied for all aspects of their potential therapeutic value in medicine. The search for plant chemicals with potential activity for treatment of deseases and industrial utilization have been initiated successfully in our laboratories. in combination with biological evaluation. Many members of the genus Artocarpus and Morus (Moraceae) are used in tradirional folk medicine in the tropical and subtropical regions of south and southeast Asia. In this paper, our recent works on the chemistry of Artocarpus lanceifolius and Morus macroura the endemic and endangered species to Indonesia, which led to the isolation of many new, unique and novel phenolic compounds and their bioactivities will be pre...