Luo Xiaomin
Central South University
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Featured researches published by Luo Xiaomin.
Progress in Biochemistry and Biophysics | 2009
Luo Xiaomin; Z. O U Hai-Yan; Zhang Zhe; P. A N Ai-Hua; Yin Fang; W. E I Miao; Yang Jing; Huang He
In order to investigate the mechanisms of pregnancy associated with diabetes harm to gravida and fetal, The Kunming mice models for pregnancy associated with diabetes were simulated , The effects of glucose in different concentrations was detected on the growth of embryo cells in vitro culture. The effects of IGF-1 in different concentrations was determined on the development of blastocyst in hyperglycemic conditions (30.0 mol/L glucose) in vitro, as well as the apoptosis of embyro cells by using nuclear DNA double-dyed assays. Moreover, the expression of igf-1 and other genes associated with apoptosis in vitro embryo was detcted by Real-time quantitative PCR. The results showed that the total cell number of blastocyst fell off along with the increasing of glucose concentration. High concentrations of glucose (≥30 mmol/L) could significantly inhibit the growth of embryo cells (P 0.01). The results of real-time quantitative PCR showed that the expression of igf-1 was down-regulated in mouse blastocyst with pregnancy associated with diabetes, and positively correlated with the concentration of glucose. The expressions of apoptosis-related genes bcl-2 and bcl-xl were up-regulated along with the increasing of IGF-1 concentration, while the p53 gene and the apoptosis-related gene Bax were down-regulated. The embryo cells apoptosis had been gradually reduced with the increasing of IGF-1 concentration in vitro, and in the IGF-1 concentration of 100 μg/L, there was almost no apoptosis in embryo cells. These experiments demonstrated that hyperglycemic conditions in vitro can inhibit the growth and development of the embryo cells resulting in the down-regulated expression of igf-1, and IGF-1 could inhibit the apoptosis of blastocyst and be benefit for the growth of blastocyst.
Archive | 2014
Luo Xiaomin; Zhang Peng; Feng Jianyan; Ge Binghui; Cao Min
Archive | 2015
Luo Xiaomin; Yang Feifei; Qu Jianbo; Feng Jianyan; Liu Rui; Zhang Peng
Archive | 2013
Luo Xiaomin; Zhang Zhe; Yang Feifei; Feng Jianyan; Zhang Peng; Liu Rui
Archive | 2015
Luo Xiaomin; Ge Binghui; Feng Jianyan; Cao Min
Archive | 2015
Wang Xuechuan; Feng Jianyan; Wan Pengpeng; Li Hui; Luo Xiaomin; Wang Jingping
Archive | 2017
Luo Xiaomin; Cao Min; Feng Jianyan; Wei Mengyuan
Archive | 2017
Luo Xiaomin; Cao Min; Feng Jianyan; Wei Mengyuan
Archive | 2017
Wang Xuechuan; Feng Jianyan; Luo Xiaomin; Wei Mengyuan; Wang Yansong; Zhao Wen
Archive | 2017
Luo Xiaomin; Cao Min; Feng Jianyan; Wei Mengyuan