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Featured researches published by Lynda McGahan.


Infection Control and Hospital Epidemiology | 2012

Preoperative Skin Antiseptic Preparations for Preventing Surgical Site Infections: A Systematic Review

Chris Kamel; Lynda McGahan; Julie Polisena; Monika Mierzwinski-Urban; John M. Embil

OBJECTIVE To evaluate the clinical effectiveness of preoperative skin antiseptic preparations and application techniques for the prevention of surgical site infections (SSIs). DESIGN Systematic review of the literature using Medline, EMBASE, and other databases, for the period January 2001 to June 2011. METHODS Comparative studies (including randomized and nonrandomized trials) of preoperative skin antisepsis preparations and application techniques were included. Two researchers reviewed each study and extracted data using standardized tables developed before the study. Studies were reviewed for their methodological quality and clinical findings. RESULTS Twenty studies (n = 9,520 patients) were included in the review. The results indicated that presurgical antiseptic showering is effective for reducing skin flora and may reduce SSI rates. Given the heterogeneity of the studies and the results, conclusions about which antiseptic is more effective at reducing SSIs cannot be drawn. CONCLUSIONS The evidence suggests that preoperative antiseptic showers reduce bacterial colonization and may be effective at preventing SSIs. The antiseptic application method is inconsequential, and data are lacking to suggest which antiseptic solution is the most effective. Disinfectant products are often mixed with alcohol or water, which makes it difficult to form overall conclusions regarding an active ingredient. Large, well-conducted randomized controlled trials with consistent protocols comparing agents in the same bases are needed to provide unequivocal evidence on the effectiveness of one antiseptic preparation over another for the prevention of SSIs.


Canadian Journal of Ophthalmology-journal Canadien D Ophtalmologie | 2010

Pharmacologic management of neovascular age-related macular degeneration: systematic review of economic evidence and primary economic evaluation

William Hodge; Allan Brown; Steve Kymes; Alan F. Cruess; Gord Blackhouse; Robert Hopkins; Lynda McGahan; Sanjay Sharma; Irene Pan; Jason Blair; David Vollman; Andra Morrison

OBJECTIVE To examine the economic implications for the Canadian health system of pharmacologic treatment of neovascular age-related macular degeneration (AMD). DESIGN Systematic review of economic literature and a primary economic evaluation. PARTICIPANTS Economic literature search identified 392 potentially relevant articles, 12 of which were included for final review. METHODS Studies were included if they met the following criteria: (i) provision of a summary measure of the trade-off between costs and consequences; (ii) participants of 40 years and older with neovascular AMD; (iii) interventions and comparators: comparison of photodynamic therapy using verteporfin (V-PDT), pegaptanib, bevacizumab, ranibizumab, anecortave acetate, intravitreal triamcinolone, placebo, or clinically relevant combinations; and (iv) outcome reported as an incremental measure of the implication of moving from the comparator to the intervention. The following databases were searched through the OVID interface: MEDLINE, EMBASE, BIOSIS Previews, CINAHL, PubMed, Health Economic Evaluations Database (HEED), and the Cochrane Library. For the economic evaluation, we took a decision analytic approach and modeled a cost-utility analysis, conducting it as a microsimulation of a Markov model. RESULTS In general, V-PDT is more cost effective than conventional macular laser, and pegaptanib is likely more cost effective than V-PDT. The primary economic analysis revealed ranibizumab to be effective but at an unacceptably high cost per quality-adjusted life year (QALY)(>


Open Medicine | 2007

Safety and effectiveness of point-of-care monitoring devices in patients on oral anticoagulant therapy: a meta-analysis

Phil Wells; Allan Brown; James Jaffey; Lynda McGahan; Man-Chiu Poon; Karen Cimon

50,000 per QALY). CONCLUSIONS Although ranibizumab is effective for wet AMD, its cost is unacceptably high based on cost-utility theory.


Series:CADTH Rapid Response Reports | 2011

Preoperative Skin Antiseptic Preparations and Application Techniques for Preventing Surgical Site Infections: A Systematic Review of the Clinical Evidence and Guidelines

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

AGREE Domain Descriptions

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

Levels of Evidence (EL) for Clinical Practice Guidelines

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

List of Excluded Studies and Rationale for Exclusion

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

Table 4, Critical Appraisal of NICE Clinical Practice Guideline

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

Classification of surgical wounds

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil


Archive | 2011

Quality Assessment Forms

Christopher Kamel; Lynda McGahan; Monika Mierzwinski-Urban; John M. Embil

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Monika Mierzwinski-Urban

Canadian Agency for Drugs and Technologies in Health

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Allan Brown

Canadian Agency for Drugs and Technologies in Health

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Karen Cimon

Canadian Agency for Drugs and Technologies in Health

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Andra Morrison

Canadian Agency for Drugs and Technologies in Health

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Chris Kamel

Canadian Agency for Drugs and Technologies in Health

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Irene Pan

University of Western Ontario

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