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Dive into the research topics where Lynn R. Sousa is active.

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Featured researches published by Lynn R. Sousa.


Pure and Applied Chemistry | 1975

Chiral recognition in complexation of guests by designed host molecules

Donald J. Cram; Roger C. Helgeson; Lynn R. Sousa; Joseph M. Timko; M. Newcomb; P. Moreau; F. de Jong; G. W. Gokel; Dale H. Hoffman; Linda A. Domeier; Stephen C. Peacock; Khorshed Madan; Lester Kaplan

ABSTRACT Host molecules have been designed and synthesized to selectively complex and lipophilize guest molecules. Examples of the use of the following binding interactions are given: hydrogen bonding, ion pairing, cation to n-electrons, carbonyl to n-electrons and pi-pi bonding. Multiheteromacrocycles have been prepared whose association constants with tert -butylammonium salts in chloroform range from 6 M -1 . Host molecules with built-in counterions have been prepared that selectively complex and lipophilize metal and alkylammonium cations. Locations of complementary binding sites and non-complementary steric barriers provide for selective binding by host molecules of candidate guest molecules. Locations of appropriate chiral barriers and multiple complexing sites in guest compounds have led to the complete optical resolution of host compounds by optically active amino acids, and of amino acid esters by optically active host compounds. Ratios of association constants for diastereomeric complexes in excess of ten have been obtained. A molecular basis for designing an amino acid resolving machine has been developed.


Journal of the American Chemical Society | 1973

Chiral recognition in molecular complexing

Evan B. Kyba; Kenji Koga; Lynn R. Sousa; Merrell G. Siegel; Donald J. Cram


Journal of the American Chemical Society | 1977

Crown ether model systems for the study of photoexcited state response to geometrically oriented perturbers. The effect of alkali metal ions on emission from naphthalene derivatives

Lynn R. Sousa; James M. Larson


Journal of the American Chemical Society | 1973

Chiral, hinged, and functionalized multiheteromacrocycles

Evan P. Kyba; Merrell G. Siegel; Lynn R. Sousa; G. D. Y. Sogah; Donald J. Cram


Journal of the American Chemical Society | 1974

Total optical resolution of amino esters by designed host-guest relations in molecular complexation

Lester J. Kaplan; Lynn R. Sousa; Dale H. Hoffman; Donald J. Cram


Journal of the American Chemical Society | 1972

Cyclohepatrienyldiazomethane. Its synthesis and behavior. C8H8 chemistry. X. Correlation diagrams and nodal properties

Howard E. Zimmerman; Lynn R. Sousa


Journal of the American Chemical Society | 1974

Stereochemistry of the di-.pi.-methane rearrangement at the methane carbon. Mechanistic and exploratory organic photochemistry

Howard E. Zimmerman; Jeffrey D. Robbins; Ronald D. McKelvey; Christophe J. Samuel; Lynn R. Sousa


Journal of the American Chemical Society | 1974

Mechanistic and exploratory organic photochemistry. LXXXVIII. Stereochemistry at the methane carbon in the di-.pi.-methane rearrangement

Howard E. Zimmerman; Jeffrey D. Robbins; Ronald D. McKelvey; Christopher J. Samuel; Lynn R. Sousa


ChemInform | 1975

TOTAL OPTICAL RESOLUTION OF AMINO ESTERS BY DESIGNED HOST-GUEST RELATIONSHIPS IN MOLECULAR COMPLEXATION

Lynn R. Sousa; Dale H. Hoffman; Lester J. Kaplan; Donald J. Cram


ChemInform | 1978

HOST-GUEST COMPLEXATION. PART 9. MACROCYCLIC POLYETHERS AND SULFIDES SHAPIED BY ONE RIGID DINAPHTHYL UNIT AND ATTACHED ARMS. SYNTHESIS AND SURVEY OF COMPLEXING ABILITIES

Donald J. Cram; Roger C. Helgeson; Kenji Koga; Evan P. Kyba; K. Madan; Lynn R. Sousa; Merrell G. Siegel; Patrice Moreau; George W. Gokel; Joseph M. Timko; G. D. Y. Sogah

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Donald J. Cram

University of California

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Howard E. Zimmerman

University of Wisconsin-Madison

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Merrell G. Siegel

Massachusetts Institute of Technology

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F. de Jong

University of California

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G. W. Gokel

University of California

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