Lynn R. Sousa
University of California, Los Angeles
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Featured researches published by Lynn R. Sousa.
Pure and Applied Chemistry | 1975
Donald J. Cram; Roger C. Helgeson; Lynn R. Sousa; Joseph M. Timko; M. Newcomb; P. Moreau; F. de Jong; G. W. Gokel; Dale H. Hoffman; Linda A. Domeier; Stephen C. Peacock; Khorshed Madan; Lester Kaplan
ABSTRACT Host molecules have been designed and synthesized to selectively complex and lipophilize guest molecules. Examples of the use of the following binding interactions are given: hydrogen bonding, ion pairing, cation to n-electrons, carbonyl to n-electrons and pi-pi bonding. Multiheteromacrocycles have been prepared whose association constants with tert -butylammonium salts in chloroform range from 6 M -1 . Host molecules with built-in counterions have been prepared that selectively complex and lipophilize metal and alkylammonium cations. Locations of complementary binding sites and non-complementary steric barriers provide for selective binding by host molecules of candidate guest molecules. Locations of appropriate chiral barriers and multiple complexing sites in guest compounds have led to the complete optical resolution of host compounds by optically active amino acids, and of amino acid esters by optically active host compounds. Ratios of association constants for diastereomeric complexes in excess of ten have been obtained. A molecular basis for designing an amino acid resolving machine has been developed.
Journal of the American Chemical Society | 1973
Evan B. Kyba; Kenji Koga; Lynn R. Sousa; Merrell G. Siegel; Donald J. Cram
Journal of the American Chemical Society | 1977
Lynn R. Sousa; James M. Larson
Journal of the American Chemical Society | 1973
Evan P. Kyba; Merrell G. Siegel; Lynn R. Sousa; G. D. Y. Sogah; Donald J. Cram
Journal of the American Chemical Society | 1974
Lester J. Kaplan; Lynn R. Sousa; Dale H. Hoffman; Donald J. Cram
Journal of the American Chemical Society | 1972
Howard E. Zimmerman; Lynn R. Sousa
Journal of the American Chemical Society | 1974
Howard E. Zimmerman; Jeffrey D. Robbins; Ronald D. McKelvey; Christophe J. Samuel; Lynn R. Sousa
Journal of the American Chemical Society | 1974
Howard E. Zimmerman; Jeffrey D. Robbins; Ronald D. McKelvey; Christopher J. Samuel; Lynn R. Sousa
ChemInform | 1975
Lynn R. Sousa; Dale H. Hoffman; Lester J. Kaplan; Donald J. Cram
ChemInform | 1978
Donald J. Cram; Roger C. Helgeson; Kenji Koga; Evan P. Kyba; K. Madan; Lynn R. Sousa; Merrell G. Siegel; Patrice Moreau; George W. Gokel; Joseph M. Timko; G. D. Y. Sogah