M. Aguilar-Santelises
Instituto Politécnico Nacional
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Publication
Featured researches published by M. Aguilar-Santelises.
Medical Oncology | 2014
Alejandro Francisco-Cruz; M. Aguilar-Santelises; Octavio Ramos-Espinosa; Dulce Mata-Espinosa; Brenda Marquina-Castillo; Jorge Barrios-Payán; Rogelio Hernández-Pando
Abstract Granulocyte–macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF has additional effects that may be far more relevant than its haematopoietic activity. GM-CSF induces differentiation, proliferation and activation of macrophages and dendritic cells which are necessary for the subsequent T helper cell type 1 and cytotoxic T lymphocyte activation. GM-CSF haematopoietic and non-haematopoietic functions have pro-inflammatory and immune regulatory potential to treat a variety of autoimmune diseases and tumours. On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential.
International Journal of Experimental Pathology | 2015
Mario Juárez-Ortega; Víctor Gabriel Hernández; Patricia Arce-Paredes; Enrique B. Villanueva; M. Aguilar-Santelises; Oscar Rojas-Espinosa
Leprosy is a disease consisting of a spectrum of clinical, bacteriological, histopathological and immunological manifestations. Tuberculoid leprosy is frequently recognized as the benign polar form of the disease, while lepromatous leprosy is regarded as the malignant form. The different forms of leprosy depend on the genetic and immunological characteristics of the patient and on the characteristics of the leprosy bacillus. The malignant manifestations of lepromatous leprosy result from the mycobacterial‐specific anergy that develops in this form of the disease. Using murine leprosy as a model of anergy in this study, we first induced the development of anergy to Mycobacterium lepraemurium (MLM) in mice and then attempted to reverse it by the administration of dialysable leucocyte extracts (DLE) prepared from healthy (HLT), BCG‐inoculated and MLM‐inoculated mice. Mice inoculated with either MLM or BCG developed a robust cell‐mediated immune response (CMI) that was temporary in the MLM‐inoculated group and long‐lasting in the BCG‐inoculated group. DLE were prepared from the spleens of MLM‐ and BCG‐inoculated mice at the peak of CMI. Independent MLM intradermally‐inoculated groups were treated every other day with HLT‐DLE, BCG‐DLE or MLM‐DLE, and the effect was documented for 98 days. DLE administered at a dose of 1.0 U (1 × 106 splenocytes) did not affect the evolution of leprosy, while DLE given at a dose of 0.1 U showed beneficial effects regardless of the DLE source. The dose but not the specificity of DLE was the determining factor for reversing anergy.
Cogent Environmental Science | 2017
Vladimir Paredes-Cervantes; Jane Castillo-Vera; Federico Gomez-Reynoso; Francisco Díaz-Cedillo; M. Aguilar-Santelises
Abstract Organotin compounds are man-made chemicals used worldwide for diverse applications. These organometallic compounds may be released from antifouling paints, polyvinyl chloride and other materials into terrestrial and aquatic environments. Mexico City is a highly populated and industrialized city with many potential sources of environmental pollution. We evaluated the content of butyltins, triphenyltin and bacteria in water from various sites with different water quality in Mexico City, Pachuca City and two towns located between these two cities. Butyltins and/or triphenyltin were detected by gas chromatography and mass spectrometry analysis in samples from 4/4 sites containing wastewater, 1/2 sites containing reclaimed water and 2/5 sites holding accumulated water in open-air deposits. Neither organotin compounds nor bacteria were found in household water samples. However, 80 bacterial strains were isolated from partially treated or untreated wastewater and 72 of them were identified at the genus and species levels by the automated Mass Spectrometry Identification System VITEK MS. In vitro growth of 16 of 28 tested strains was not inhibited by 1 mM tributyltin or triphenyltin, indicating that many environmental bacteria are highly tolerant to organotin compounds.
International Conference on Education and New Learning Technologies | 2017
M. Cruz-Millán; M. Aguilar-Santelises; Araceli García del Valle; M.T. Corona-Ortega; A.G. Rojas-Fernández; L. Aguilar-Santelises
Various strategies may be applied for teaching statistics. Lectures, equipment, teamwork and guidance are all important to help students to become capable of using statistics to analyse their own work and the results produced by others. Students following the second year from the Chemistry Pharmacology and Biology curricula (QFB) in the Faculty for Higher Studies Zaragoza (FES-Z), UNAM start becoming familiar with simple concepts and procedures, such as percentage, average, mean, median, standard deviation, standard error, confidence intervals and probability. They also learn to correctly elaborate standard curves and to interpret both graphically and statistically the results of their experiments. Our university provides wired and inalambric facilities for a wide and fast access to the institutional and public networks. The information can be accessed from various devices, like tablets, smartphones, personal and institutional computers. Thus, the students can connect, search, upload, download and interact in various ways through digital means. Our institution’s policy is to guarantee that limited access or insufficient knowledge of information and communication technologies (ICT) will not be a barrier for our students. Instead, they may benefit from state-of-the art digital communication systems and guided learning to use them properly [1]. The students receive files containing full information about experiments designed to answer specific questions. Then, by using their knowledge on statistical procedures and interpretation of results, they must describe, analyse and conclude if the experiments have been properly performed and what is the significance of the results. Teams of 4 or 6 students are formed in order to promote exchange of information, collaboration and discussion. Teachers are always following their progress, making comments and helping them to resolve their doubts [2]. This tutorial-guided students’ teamwork stimulates and promotes critical analysis of information and problem solving thinking [3]. Students’ capacity to develop critical thinking and proper application of statistics are both important qualities for a solid academic development.
EDULEARN18 Proceedings | 2018
L. Aguilar-Santelises; Araceli García del Valle; M. Aguilar-Santelises; M.T. Corona-Ortega; M. Cruz-Millán; J.D. Alemán-Suárez
Multidisciplinary Journal for Education, Social and Technological Sciences | 2017
A.G. Rojas-Fernández; L. Aguilar-Santelises; Margarita Cruz Millán; M. Aguilar-Santelises; Araceli García del Valle
International Conference on Education and New Learning Technologies | 2017
L. Aguilar-Santelises; M. Cruz-Millán; M. Aguilar-Santelises; J.D. Alemán-Suárez; M.T. Corona-Ortega; A.G. Rojas-Fernández; Araceli García del Valle
International Conference on Education and New Learning Technologies | 2016
M. Cruz-Millán; M. Aguilar-Santelises; Araceli García del Valle; A.G. Rojas-Fernández; L. Aguilar-Santelises
Multidisciplinary Journal for Education, Social and Technological Sciences | 2015
Araceli García del Valle; M.T. Corona-Ortega; M. Cruz-Millán; A.G. Rojas-Fernández; M. Aguilar-Santelises; Leonor Aguila-Santelises
EDULEARN15 Proceedings | 2015
L. Aguilar-Santelises; M.T. Corona-Ortega; M. Cruz-Millán; M. Aguilar-Santelises; A.G. Rojas-Fernández; A. García-del Valle