M. Amouri

Sweet's syndrome: a retrospective study of 90 cases from a tertiary care center.

Sweets syndrome (SS) is a neutrophilic dermatosis characterized by the abrupt onset of cutaneous, systemic and histopathological alterations in response to different stimuli.

Aplasia cutis congenita: report of 22 cases.

Aplasia cutis congenita (ACC) is a rare malformation characterized by absent or scarred areas of skin at birth. Although most commonly found on the scalp, ACC can also involve other locations. Its etiology and pathogenesis remain unclear.

Mémoire originalLa phénolisation : un nouveau traitement des chéloïdesTreatment of keloid with phenol: A new therapy

PURPOSE Evaluation of a new treatment for keloid scars using a 40% phenol solution in accordance with a predefined protocol. PATIENTS AND METHODS A retrospective study was made of the files of 25 patients treated with phenol from June 2010 to March 2012. RESULTS The keloids were located predominantly on the trunk (48%) and upper extremities (34%). The total number of keloids was 52, with a median size of 11.16 cm(2). Phenol was the sole and first-line treatment in 40% of cases. Patient adherence to the protocol of phenol was noted in 81% of cases. The mean number of phenol sessions was 14.2. Seventy-two percent of patients were satisfied with the treatment. Mean regression in keloid size of 75.5% was noted. A change in local keloid pigmentation was observed in 75% of patients. Local adverse reactions (itching, infection, ulceration) were seen in 6 patients (28.6%). No cases of systemic signs of phenol were observed. After mean follow-up of 12.8 months, no recurrence of keloids was noted. CONCLUSION Use of phenols in the topical treatment of keloids appears valuable since it is easy to apply and provides good results with few side effects.

La phénolisation : un nouveau traitement des chéloïdes

PURPOSE Evaluation of a new treatment for keloid scars using a 40% phenol solution in accordance with a predefined protocol. PATIENTS AND METHODS A retrospective study was made of the files of 25 patients treated with phenol from June 2010 to March 2012. RESULTS The keloids were located predominantly on the trunk (48%) and upper extremities (34%). The total number of keloids was 52, with a median size of 11.16 cm(2). Phenol was the sole and first-line treatment in 40% of cases. Patient adherence to the protocol of phenol was noted in 81% of cases. The mean number of phenol sessions was 14.2. Seventy-two percent of patients were satisfied with the treatment. Mean regression in keloid size of 75.5% was noted. A change in local keloid pigmentation was observed in 75% of patients. Local adverse reactions (itching, infection, ulceration) were seen in 6 patients (28.6%). No cases of systemic signs of phenol were observed. After mean follow-up of 12.8 months, no recurrence of keloids was noted. CONCLUSION Use of phenols in the topical treatment of keloids appears valuable since it is easy to apply and provides good results with few side effects.

Cas cliniqueXanthogranulomes juvéniles disséminés exprimant la protéine S100Disseminated juvenile xanthogranuloma expressing protein S100

BACKGROUND Juvenile xanthogranuloma (JXG) is a form of self-healing non-Langerhans histiocytosis. We report a new case of disseminated JXG without visceral involvement but with positive immunostaining of the majority of histiocytes for protein S100. PATIENTS AND METHODS A 6-month-old male infant was admitted to our department in January 2010 for congenital nodular lesions of varying size, shape and appearance. The remainder of the dermatological and physical examination was unremarkable. The diagnosis of disseminated JXG, strongly suggested clinically, was confirmed by a skin biopsy. However, immunohistochemistry was confusing, with positivity for protein S100. The lesions regressed spontaneously. DISCUSSION The aim of this case report is to highlight the lack of any forced association between alarming skin lesions of eruptive JXG and systemic involvement. The distinguishing feature of our case is the positive immunostaining for protein S100 in the histological section, which although rare in XJG, does not cast doubt on the diagnosis of non-Langerhans histiocytosis providing the clinical presentation is typical. Therapeutic abstention is the rule.

Xanthogranulomes juvéniles disséminés exprimant la protéine S100

BACKGROUND Juvenile xanthogranuloma (JXG) is a form of self-healing non-Langerhans histiocytosis. We report a new case of disseminated JXG without visceral involvement but with positive immunostaining of the majority of histiocytes for protein S100. PATIENTS AND METHODS A 6-month-old male infant was admitted to our department in January 2010 for congenital nodular lesions of varying size, shape and appearance. The remainder of the dermatological and physical examination was unremarkable. The diagnosis of disseminated JXG, strongly suggested clinically, was confirmed by a skin biopsy. However, immunohistochemistry was confusing, with positivity for protein S100. The lesions regressed spontaneously. DISCUSSION The aim of this case report is to highlight the lack of any forced association between alarming skin lesions of eruptive JXG and systemic involvement. The distinguishing feature of our case is the positive immunostaining for protein S100 in the histological section, which although rare in XJG, does not cast doubt on the diagnosis of non-Langerhans histiocytosis providing the clinical presentation is typical. Therapeutic abstention is the rule.

Hamartome angio-eccrine

1987年 か ら1996年 の10年 間 に 当科 に お い て 病 理 組 織 学 的 に血 管 腫 あ る い は リ ンパ 管 腫 と診 断 さ れ た 57例 に つ い て エ ッ ク リン汗 腺 の 増 生 につ い て検 討 した 。 そ の 結 果,57例 中14例(24.6%)と 高 率 に エ ッ ク リン 汗 腺 の 増 生 を伴 って い た 。 性 別 で は男 性 に 多 く,年 齢 別 で は若 年 者 に高 率 に エ ック リ ン汗 腺 の 増 生 を認 め た 。 ま た,病 理 組 織 学 的 に は血 管 腫45例 中7例(15.6%),リ ンパ 管腫12例 中7例(58 .3%)と リン パ 管 腫 に 高 率 に エ ック リ ン汗 腺 の 増 生 を認 め た 。 こ れ らの 結 果 か ら血 管 腫,リ ンパ 管 腫 の-部 は, エ ック リン汗 腺 の 増 生 を伴 う潜 在 能 力 を持 った母 斑 で あ ろ う と考 え た 。(皮 膚 ,40:21-24,1998)

Angiolymphoid hyperplasia with eosinophilia: report of nine cases

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign vascular proliferation characterized by dermal or subcutaneous red or brown papules or nodules, most commonly on the head and neck.

P 98 : Basal cell carcinoma : A common tumor, uncommon locations

Introduction Basal cell carcinoma (BCC), the most common skin cancer, is mostly localized in the cephalic region. The BCC that arise in sun-protected sites are quite uncommon. If ultraviolet rays are on the base of the genesis of classical BCC, they are insufficient to explain the occurrence of CBC in non-sun-exposed parts of the body. The aim of our work is to highlight the epidemiological, clinical and evolutive characteristics of extra cephalic BCC. Materiel et methods Retrospective study of the files of patients followed for BCC that arise in sun-protected sites including those of the neck, and having a histological confirmation, over a period of 20 years (1995-2014). Results 68 patients with one or more extra cephalic BCC (76 BCC) were seen over 25 years, they presented 5,5% of 1 237 patients with BCC, recorded during the same period. We noted a previous trauma in the same seat (2 cases), a loco regional radiotherapy for blood disease (2cases) or for ringworm (1case), an oculocutaneous albinism (2cases) and a xeroderma pigmentosum (1case). The average age of onset of the BCC was 57,5 years (range : 11 and 102 ans). Mean age at diagnosis was 62 years. Median duration of BCC pre-diagnosis was 4,7 years. All our patients were Caucasian with a male to female sex ratio of 1,6. The size of the tumor, ranging from 0.5 to 15 cm (mean size : 2,6 cm) was over than 10 cm in 2 cases. The trunk was the most affected site (47.5%) with predominance (30%) at its front side (abdomen, thorax). The nodular form was predominant (35 cases : 46%) followed by the flat scar form (10 cases : 13%). Five patients (7.5%) had multiple simultaneous BCC in sun-protected sites. The histological type was mostly nodular (43 cases : 56.5%) followed by the ulcerated type (19 cases : 25%). Invasive tumor was noted in 5 cases (2 ulcerative and 3 nodular types). No lymphadenopathy or metastasis was noted. Wide local excision was the treatment method used most commonly (75 cases). Only 1 case was treated with CO2 laser. Adjuvant radiotherapy was needed in one case. A follow-up from 5 months to 5 years did not notice recurrence or metastasis. Conclusion The BCC occurring on sun-protected regions is a rare phenomenon. The concept of contributing factors is a reality. The predominance of the arising in the trunk and the nodular form is clear. The prognosis joins that of other BCCs

Tumeur virilisante de l’ovaire : une cause rare d’alopécie androgénétique

dans 2 cas. Les néoplasies associées étaient : l’adénocarcinome pulmonaire, le mélanome acrolentigineux, le carcinome épidermoïde du larynx, la leucémie lymphoïde chronique B et le la maladie de Hodgkin. Ces néoplasies précédaient le LTC chez 2 patients ayant reçu une chimiothérapie, et étaient de découverte concomitante dans 2 cas et 6 ans plus tard chez une patiente traitée par méthotrexate. Discussion.— La survenue chez un même patient d’un LTC et d’une autre néoplasie primitive est rare. Il s’agit le plus souvent de néoplasies solides ou d’hémopathies malignes. Ces associations pourraient résulter de facteurs environnementaux, génétiques ou d’une infection sous-jacente par un virus oncogène. L’effet mutagène des chimiothérapies et certaines anomalies constitutionnelles des lymphocytes T et du système des cytokines ont été également incriminés. Une altération d’une cellule souche pourrait expliquer l’association de lymphomes B et T. Conclusion.— Les explorations initiales et de suivi des lymphomes cutanés primitifs sont loin d’être standardisées. Un contrôle périodique régulier est nécessaire pour un dépistage précoce de ces associations et de leurs facteurs favorisants individuels et environnementaux. Déclaration d’intérêt.— Aucun.