M. Anıl Onan

Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients with Insulin Resistance

In this study, our objective was to evaluating the value of serum zinc levels as an etiologic and prognostic marker in patients with polycystic ovarian syndrome. We conducted a prospective study, including 53 women with polycystic ovarian syndrome and 33 healthy controls. We compared serum zinc levels, as well as clinical and metabolic features, of the cases. We also compared serum zinc levels between patients with polycystic ovarian syndrome with insulin resistance. Mean zinc levels were found to be significantly lower in patients with polycystic ovarian syndrome than healthy controls. Multiple logistic regression analysis of significant metabolic variables between polycystic ovarian syndrome and control groups (serum zinc level, body mass index, the ratio of triglyceride/high-density lipoprotein cholesterol, and homocysteine) revealed that zinc level was the most significant variable to predict polycystic ovarian syndrome. Mean serum zinc levels tended to be lower in patients with polycystic ovarian syndrome with impaired glucose tolerance than patients with normal glucose tolerance, but the difference was not statistically significant. In conclusion, zinc deficiency may play a role in the pathogenesis of polycystic ovarian syndrome and may be related with its long-term metabolic complications.

Spontaneous iliopsoas haematoma during heparin anticoagulation: Cause of fetal loss

Journal of the American College of Cardiology 33:1642– 1645. Mahesh B, Evans S, Bryan AJ. 2002. Low molecular weight heparin (tinzaparin) therapy for moderate risk thromboprophylaxis during pregnancy. Failure of low molecular weight heparin in the prevention of prosthetic mitral valve thrombosis during pregnancy: case report and a review of options for anticoagulation. Journal of Heart Valve Disease 11:745–750. Salazar E, Izaguirre R, Verdejo J, Mutchinick O. 1996. Failure of adjusted doses of subcutaneous heparin to prevent thromboembolic phenomena in pregnant patients with mechanical cardiac valves prostheses. Journal of the American College of Cardiology 27:1698–1703. Sbarouni E, Oakley CM. 1994. Outcome of pregnancy in women with valve prostheses. British Heart Journal 71:196–201. Weitz JL. 1997. Low molecular weight heparins. New England Journal of Medicine 337:668–698.

Prenatal diagnosis of achondrogenesis type I: a case report

IntroductionAchondrogenesis is a lethal osteochondrodysplasia characterized by hypoplasia of the bones and is associated with various anomalies varying in severity. Based on clinical, radiologic, and histopathologic features, two types are distinguished.Case presentationThe prenatal ultrasound examination of a 32-year-old Turkish woman who was referred to our clinic at 33 weeks and 6 days of gestation revealed fetal micromelia together with several other anomalies. The female baby died shortly after birth and was diagnosed with achondrogenesis type I based on the clinical and radiographic findings.ConclusionUltrasonography is important in prenatal diagnosis and for distinguishing lethal skeletal dysplasias in order to counsel the parents about future recurrent risks. As it is a uniformly lethal disease, a definitive prenatal diagnosis of achondrogenesis may be an indication for pregnancy termination.

A rare case of ovarian cancer in a pregnant woman with metastatic non-small cell lung cancer

Lung cancer is the most common cancer affecting both the sexes worldwide (Wong et al. 2003). Because it is very rare to see lung cancer in pregnancy and vice versa (Boussios et al. 2013), our knowledge of the management of these pregnancies is small and only a limited number of case reports or series are to be found in the literature. In this report, we described a patient with metastatic nonsmall cell lung cancer (NSCLC) who was also diagnosed with ovarian cancer in pregnancy.

Effects of ritodrine hydrochloride tocolysis on echocardiographic parameters.

Objective. Preterm delivery is a leading cause of perinatal mortality and morbidity. The aim of this study was to determine the effect of ritodrine hydrochloride, used for tocolysis and having serious cardiovascular side effects, on echocardiographic parameters. Methods. Sixty-two pregnant women were included in our study. The study and control groups were composed of patients with preterm labor (group A, N = 30) and patients with uneventful pregnancies (group B, N = 32), respectively. While the patients in group A were evaluated before and during treatment, those in group B were evaluated only once for ejection fraction and fractional shortening of the left side of the heart with echocardiography and for the regional systolic and diastolic functions with the tissue Doppler technique. One-way ANOVA and a t-test (paired comparison) were used for statistical purposes. Results. For the left side of the heart, it was shown that while fractional shortening increased with tocolysis (p < 0.05), neither the ejection fraction nor E/A ratio, showing diastolic function, changed significantly (p < 0.01). While systolic function parameters (Sasep and Salat) increased due to the inotropic and chronotropic actions of the beta-mimetic agents (p < 0.05), regional diastolic function parameters (Easep/Aasep and Ealat/Aalat) did not change (p > 0.05). Conclusions. Due to its potent inotropic and chronotropic effects, ritodrine hydrochloride increases myocardial oxygen demand significantly. Therefore, it should be used sparingly or avoided altogether in patients with ischemic or structural heart disease.