M. Axelsson
Aarhus University
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Publication
Featured researches published by M. Axelsson.
Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology | 1998
Malcolm E. Forster; William Davison; M. Axelsson; Lena Sundin; Craig E. Franklin; Steven P. Gieseg
Abstract Two species of Antarctic fish were stressed by moving them from seawater at −1 °C to seawater at 10 °C and holding them for a period of 10 min. The active cryopelagic species Pagothenia borchgrevinki maintained heart rate while in the benthic species Trematomus bernacchii there was an increase in heart rate. Blood pressure did not change in either species. Both species released catecholamines into the circulation as a consequence of the stress. P. borchgrevinki released the greater amounts, having mean plasma concentrations of 177 ± 54 nmol · l−1 noradrenaline and 263 ± 131 nmol · l−1 adrenaline at 10 min. Plasma noradrenaline concentrations rose to 47 ± 14 nmol · l−1 and adrenaline to 73 ± 28 nmol · l−1 in T. bernacchii. Blood from P. borchgrevinki was tonometered in the presence of isoprenaline. A fall in extracellular pH suggests the presence of a Na+/H+ antiporter on the red cell membrane, the first demonstration of this in an Antarctic fish. Treatment with the β-adrenergic antagonist drug sotalol inhibited swelling of red blood cells taken from temperature-stressed P. borchgrevinki, suggesting that the antiporter responds to endogenous catecholamines.
Journal of Comparative Physiology B-biochemical Systemic and Environmental Physiology | 2001
M. Axelsson; Craig E. Franklin
Abstract. The foramen of Panizza is located within the outflow tract of the crocodilian heart, between the left and right aortas. It has been suggested that the foramen of Panizza has a variable calibre, which could explain the profound changes in the distribution of flows and pressure profiles recorded in the right and left aortas. We investigated this possibility using a modified in-situ perfused heart preparation in combination with isolated strip preparations from the outflow tract. In the perfused heart preparation, bolus injections of adrenaline increased the resistance in the foramen of Panizza, indicating a decrease in its diameter. Isolated strip preparations from the outflow tract showed a concentration-dependent increase in tension in response to adrenaline, while vasoactive intestinal polypeptide caused a relaxation in adrenaline pre-contracted strip preparations. We propose that an increase in the diameter of the foramen of Panizza may be important during pulmonary to systemic shunts to allow blood to flow from the left to right aorta (reverse foramen flow) in order to supply the carotid and coronary arteries. During non-shunting conditions, a constricted foramen may prevent excess flow from the right to left aorta during diastole.
The Journal of Experimental Biology | 1998
Jordi Altimiras; Craig E. Franklin; M. Axelsson
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 1994
Susanne Holmgren; Regina Fritsche; Paul Karila; Ian L. Gibbins; M. Axelsson; Craig E. Franklin; Gordon C. Grigg; Stefan Nilsson
American Journal of Physiology-regulatory Integrative and Comparative Physiology | 1996
Stefan Nilsson; Malcolm E. Forster; William Davison; M. Axelsson
The Journal of Experimental Biology | 2000
P. L. R. Andrews; M. Axelsson; Craig E. Franklin; Susanne Holmgren
The Journal of Experimental Biology | 1994
Lena Sundin; M. Axelsson; Stefan Nilsson; William Davison; Malcolm E. Forster
Archive | 2004
Craig E. Franklin; M. Axelsson; Lena Sundin; William Davison
Comparative Biochemistry and Physiology A-molecular & Integrative Physiology | 2005
Anthony P. Farrell; Jordi Altimiras; Craig E. Franklin; Guy Claireaux; M. Axelsson
Archive | 2001
M. Axelsson; Jordi Altimiras; Koullis Pitsillides