M. Beretta

Isonymy and the genetic structure of Switzerland I. The distributions of surnames

The surname distribution of the population of Switzerland was studied using a sample of 1,702,000 private users registered for the year 1994 in the Helvetic Telephone Directory. These users were distributed in four linguistic areas, in 26 Cantons and 271 Communes of the Confederation. Estimates of unbiased random isonymy, of Fishers alpha, an indicator of abundance of surnames converging to the allele effective number in standard genetic polymorphisms, and of Karlin-McGregors v, an indicator of immigration rates, were calculated for each Commune, each Canton, each linguistic area and for the whole Confederation. The Commune with the highest value of alpha was Geneva (alpha = 5312) followed by Versoix (3713) and by the Communes of Vaud on the north shore of Lake Leman, Chavannes (3381), Montreux (3200), Nyon (3114) and Lausanne (3109). The Italian-speaking Communes of the Ticino were next. The lowest value (alpha = 29) was observed in Poschiavo, south of the Berninapass; alpha = 39 was observed in Einsiedeln (Schwyz); then Mels and Widnau (62 and 67, Canton of St Gallen), Frutingen in Bern (72), and Appenzell (80). Accordingly, the highest consanguinity values were observed in the Grisons and in the nucleus of the founding Cantons, while the lowest were observed in the Cantons of Geneva and Vaud, preferential areas of immigration to Switzerland from abroad. The effect of subdivision on isonymy is large at the Commune level, and decreases in Cantons and linguistic groups. French and Italian languages indicate minor, German and Romanisch major inbreeding.

Isonymy and the genetic structure of Switzerland. II. Isolation by distance

Isolation by distance in Switzerland was detected comparing the surname distributions between Cantons. The decay of isonymy with geographic distance between Cantons was consistent with Malecots exponential decay of kinship. Laskers distance was defined as the negative value of the logarithm of isonymy between localities, and it was found that it is linearly and significantly correlated with the log of geographic distance, both within and between languages. The peculiar geographic and linguistic structure of the Confederation, where mountain barriers exist at short distances separating different languages, might explain the rapid changes in surname similarity. It was predicted that the frequency of markers linked to the Y chromosome would show a similar association with distance in Switzerland.

Microevolution in Ferrara: Isonymy 1890–1990

The distribution of surnames in the population of the town of Ferrara, as it existed in the memory banks of the Municipality Computer in June 1990, was studied by sex, age and place of birth of residents. Random isonymy was studied separately in persons born before 1901, and in persons born in the nine decades thereafter, ending with the period 1981-90. Isonymy was higher in the older age groups studied. Also other indicators of the abundance of surnames in the distribution, the common ecological indexes derived from entropy, were calculated and compared between age groups. It was found that redundancy, as isonymy, is larger in older age classes than in younger classes. Surname effective number was defined as the inverse of isonymy corrected for sample size, and it was observed that it is practically identical with Fishers alpha. It was then possible to separate random isonymy into two components, so that for sample size N its formulation becomes Ir = 1/alpha + 1/N It was found that in Ferrara alpha increased significantly in time, indicating enrichment of surnames in the population in the century 1890-1990.

Isolation by distance in Germany.

ing surname distributions of private telephone users registered in a 1996 commercial CD-ROM that contains all the users in the country. We have the preliminary results from a sample of more than five million surnames of users distributed in 106 towns selected on a geographical basis. Germany was subdivided into 50 adjacent rectangles of 115 × 80 kms; at least the largest town in the rectangle was selected and the private telephone users in its district were downloaded from the CD-ROM and included in the analysis. The number of different surnames found in the whole analysis was 462580. Lasker’s distance, the negative value of the logarithm of isonymy between localities, was found to be linearly and significantly correlated with geographical distance, with r = 0.51 ± 0.010 (Fig. 1). A dendrogram was built from the matrix of isonymy distance, by using the UPGMA method. It separates the German towns in two main clusters, one in the southern half of the country and the other in the northern; within each half, small subclusters with specific geographical distributions can be delimited. The two main clusters correspond well to the north-south division of German sublanguages (Niederand Mitteldeutsch in the North vs Frankish-Alemannisch in the South). The other clusters are related to minor sublanguages. Comparisons with the results of a previous analysis show that isolation by distance in Germany is less strong than in Switzerland (Barrai et al. 1996; Rodriguez-Larralde et al. 1997) and indicate that this country has a homogeneous isonymy structure. The random component of inbreeding estimated from isonymy indicates that the eastern area of the nation is on average more inbred than the western area. Our work is supported by MURST grants 60% and 40%, by Agreements 132.36.1 (Italy) and PI-117 (Venezuela) CNR/CONICIT 1995–97 and by CNR grant No. 95.02119.CT04.

Isonymy in emigrants from Ferrara in 1981–1988

The distribution of surnames in the emigrants from the population of the town of Ferrara in the period 1981-88 was studied by sex and place of birth, namely Ferrara versus other places. Emigrants born in Ferrara were defined as first time emigrants and those who had previously immigrated to Ferrara were defined second time emigrants. It was found that random isonymy is smaller in second time emigrants. Sex ratio is not different in the two types of emigrants. As indicators of the abundance of surnames in a distribution, the common ecological indexes derived from entropy were used and compared between types of emigrants. It was found that redundancy, as isonymy, is larger in the first time emigrants than in second time emigrants. It was observed that second time emigrants were consistently and significantly older than first time emigrants, and that a considerable fraction of them, (22.4%) returned to their place of birth. A sexual dimorphism in age at emigration was observed in second time emigrants, females emigrating at an older age than males.

Isonymy in records of births and deaths in Ferrara

Surname distributions were studied in records of male and female births in Ferrara in the period 1982-89, and in records of male and female deaths in the same period. Average year of birth and standard deviation was 1985 +/- 2.3 for the birth series, and 1912 +/- 14.4 for the death series. Then the surname distributions, in two independent samples at an average distance of 73 years, were compared. It was observed that random isonymy within series, which depends on the shape of the distribution, stays fairly constant at three generations of distance, indicating near-equilibrium of surname turnover. The migrational contribution is indicated by the significant decrease of random isonymy between series, measured with the method of Lasker. It was also observed that immigrants to Ferrara have a life-span significantly longer than people born in the town.

Population structure of Sicily: beta-thalassemia and HbS.

SummaryThe population structure of two alleles with similar characteristics, HbS and beta-thalassemia, was studied in the same area in Sicily. It was observed that beta-thalassemia has uniform frequencies over the island, and that HbS shows a South-North cline. A singularity exists for HbS in the town of Butera, where the frequency of the S gene is six times higher than the island average. It was suggested that HbS entered Sicily from Greece (or directly from North Africa) when the beta-thalassemia allele was already established in the Island.

Population Structure of Eastern Sicily

A sample of 465 persons from Eastern Sicily was studied for 11 red-cell enzymes, namely GLO, GPT, EsD, PGP, PGD, Dia, AcP, PGM, SOD, CAI and CAII. The allele frequencies were compared with those of other Italian populations and showed that the island is homogeneous with the mainland for these systems. The rate of heterozygosity was studied as a function of interparental distance; although high (0.77) the correlation did not reach significance.

Detection of Genetic Structures at Short Distances in the Pisa Area

The genetic structure of the population of the urban and suburban area of the town of Pisa in Tuscany in Central Italy was studied in 1,174 adults residing in 4 zones in each of 3 sampling areas, using the phenotype and gene frequencies of 9 red cell enzymes. The area investigated has a surface of about 30 km2. The enzymes were: acid phosphatase (ACP1), adenosine deaminase (ADA), adenylate kinase (AK1), esterase D (ESD), glyoxalase I (GLOI), glutamic-pyruvic transaminase (GPT), 6-phosphogluconate dehydrogenase (6-PGD), phosphogluco-mutase 1 (PGM1), and phosphoglycollate phosphatase (PGP). For the analysis of the distributions of phenotype and gene frequencies, standardised variances, kinship profiles, analysis of correspondences and isonymy were used. It was found that in this area genetic differentiation (possibly due to recent immigration) can be perceived even at short geographic distances, indicated by the significant regression of kinship on distance, especially visible in the ADA and GPT systems.

KINSHIP STRUCTURES AND MIGRATION IN THE PO-DELTA

The kinship analysis of seven genetic systems in the province of Ferrara permits some considerations on the possible chronology of emergence of their polymorphisms in the area. It is proposed that, assuming neutrality of these systems, and under several restrictions, the emergence by migration of the polymorphisms in the seven systems ACP, ESD, GLO, GPT, PGD, PGM1; PGP might have had the following sequence: PGP and GLO and possibly PGD; PGMj and GPT; ACP and ESD. All polymorphisms must be older than the β‐thalassemia polymorphism in the area.