M. Brouwer

Regulation of CD27 expression on subsets of mature T-lymphocytes.

Regulatory properties of LFA-1 alpha and beta chains in human T-lymphocyte activation

The CD27− subset of peripheral blood memory CD4+ lymphocytes contains functionally differentiated T lymphocytes that develop by persistent antigenic stimulation in vivo

Signals involved in T cell activation: T cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies

Human CD8+ T lymphocytes can be divided into CD45RA+ and CD45RO+ cells with different requirements for activation and differentiation.

Regulation of expression of CD27, a T cell-specific member of a novel family of membrane receptors.

Immobilized anti-CD3 monoclonal antibodies induce accessory cell-independent lymphokine production, proliferation and helper activity in human T lymphocytes.

Activated T cells can induce high levels of CTLA-4 expression on B cells.

DIFFERENCES IN RESPONSIVENESS TO CD3 STIMULATION BETWEEN NAIVE AND MEMORY CD4+ T CELLS CANNOT BE OVERCOME BY CD28 COSTIMULATION

T cell receptor/CD3 and CD28 use distinct intracellular signaling pathways