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Dive into the research topics where M Bugnoli is active.

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Featured researches published by M Bugnoli.


Immunobiology | 1992

Development and clinical testing of an acellular pertussis vaccine containing genetically detoxified pertussis toxin

Rino Rappuoli; Mariagrazia Pizza; Maria Teresa De Magistris; Audino Podda; M Bugnoli; Roberto Manetti; Luciano Nencioni

In 1924 Ramon described the inactivation of diphtheria toxin by formaldehyde treatment. This method allowed the introduction of mass vaccination against diphtheria and tetanus and opened the way to the inactivation of viruses by chemical treatment. In this review we describe the use of genetic manipulations for the inactivation of pertussis toxin. The toxin inactivated by this new method is an antigen superior to those obtained by chemical treatment and has been used to develop a new vaccine against whooping cough.


Journal of Experimental Medicine | 1994

Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

John L. Telford; P Ghiara; M Dell'Orco; M Comanducci; D Burroni; M Bugnoli; M F Tecce; Stefano Censini; Antonello Covacci; Z Xiang


Science | 1989

Mutants of pertussis toxin suitable for vaccine development

Mariagrazia Pizza; Antonello Covacci; Antonella Bartoloni; M Perugini; Luciano Nencioni; Mt De Magistris; Luigi Villa; D Nucci; Roberto Manetti; M Bugnoli


Archive | 1993

Helicobacter pylori proteins useful for vaccines and diagnostics

Antonello Covacci; M Bugnoli; John L. Telford; Giovanni Macchia; Rino Rappuoli


Infection and Immunity | 1990

Characterization of genetically inactivated pertussis toxin mutants: candidates for a new vaccine against whooping cough.

Luciano Nencioni; Mariagrazia Pizza; M Bugnoli; T De Magistris; A Di Tommaso; F Giovannoni; Roberto Manetti; Ilio Marsili; Giacomo Matteucci; D Nucci


Infection and Immunity | 1991

Properties of pertussis toxin mutant PT-9K/129G after formaldehyde treatment.

Luciano Nencioni; G Volpini; S Peppoloni; M Bugnoli; T De Magistris; Ilio Marsili; R. Rappuoli


Journal of Experimental Medicine | 1990

Metabolic, humoral, and cellular responses in adult volunteers immunized with the genetically inactivated pertussis toxin mutant PT-9K/129G.

Audino Podda; Luciano Nencioni; M T De Magistris; A Di Tommaso; Paola Bossù; Sandra Nuti; P. Pileri; Samuele Peppoloni; M Bugnoli; Paolo Ruggiero


Infection and Immunity | 1994

Formaldehyde treatment of proteins can constrain presentation to T cells by limiting antigen processing.

A Di Tommaso; M T De Magistris; M Bugnoli; Ilio Marsili; R. Rappuoli; Sergio Abrignani


The Lancet | 1993

Helicobacter pylori: host responses in peptic ulceration

Zhaoying Xiang; M Bugnoli; Rino Rappuoli; Antonello Covacci; Antonio Ponzetto; JeanE Crabtree


The Lancet | 1993

Detection of vacuolating toxin of Helicobacter pylori in human faeces

Ida Luzzi; Cristina Pezzella; Alfredo Caprioli; Antonello Covacci; M Bugnoli; Stefano Censini

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