M. C. Cardia | Researchain

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Featured researches published by M. C. Cardia.

Farmaco | 2002

Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues.

Elias Maccioni; M. C. Cardia; Leonardo Bonsignore; A. Plumitallo; Maria Luisa Pellerano; A De Logu

It is known that some derivatives of both thiourea and thiosemicarbazide exhibit potent anti-microbial activity. In order to investigate the effects on the biological properties of structural modifications of such structures, we have synthesised and studied some arylidenisothiosemicarbazones. In this paper we report on the synthesis and structure-activity relationships of some isothiosemicarbazones, where the arylidene group has been replaced with a cycloalkyl group and the sulfur atom has been either differently substituted or enclosed in a thiazole ring.

Farmaco | 2003

An investigation of the biological effect of structural modifications of isothiosemicarbazones and their cyclic analogues

Elias Maccioni; M. C. Cardia; Simona Distinto; Leonardo Bonsignore; A De Logu

Several arylideneisothiosemicarbazones and arylidenehydrazothiazoles have been synthesised to obtain new antimicrobial agents. Their activity against both bacteria and fungi has been tested and some interesting informations about their biological activity have been obtained.

Journal of Heterocyclic Chemistry | 2003

Synthesis and biological activity evaluation of differently substituted 1,4-dioxo-3,4-dihydrophthalazine-2(1H)-carboxamides and -carbothioamides

M. C. Cardia; Simona Distinto; Elias Maccioni; Leonardo Bonsignore; Alessandro DeLogu

Farmaco | 2004

Synthesis and anti-microbial activity evaluation of some new 1-benzoyl-isothiosemicarbazides

Antonio Plumitallo; M. C. Cardia; Simona Distinto; Alessandro DeLogu; Elias Maccioni

XXIV Congresso Nazionale della Società Chimica Italiana | 2011

New promising scaffolds for the inhibition of monoamine oxidase B

Maria Luisa Sanna; Rita Meleddu; M. C. Cardia; Simona Distinto; Stefano Alcaro; Elias Maccioni

Archive | 2011

Design and synthesis of new Isatin derivatives as HIV-1 Reverse Transcriptase associated Ribonuclease H inhibitors twenty-fourth

Francesca Esposito; Rita Meleddu; Simona Distinto; Angela Corona; Cannas; Enzo Tramontano; M. C. Cardia

1st Meeting of the Paul Ehrlich MedChem Euro-PhD Network | 2011

Design, synthesis and biological activity evaluation of new HIV-1 reverse transcriptase dual inhibitors

Rita Meleddu; Angela Corona; Simona Distinto; Maria Luisa Sanna; Francesca Esposito; M. C. Cardia; Enzo Tramontano; Elias Maccioni

XX National Meeting on Medicinal Chemistry | 2010

SYNTHESIS, MOLECULAR MODELLING, INHIBITORY ACTIVITY, AND SELECTIVITY TOWARDS MONOAMINE OXIDASE OF NEW HETEROCYCLIC SCAFFOLDS

Maria Luisa Sanna; Elias Maccioni; Stefano Alcaro; Roberto Cirilli; Rosella Ferretti; Matilde Yáñez; M. C. Cardia; Simona Distinto; Rita Meleddu; S. Vigo; Francesco Ortuso

4th European Congress of Virology | 2010

Shape based computer aided similarity screening: a valid tool in the discovery of new scaffolds for the inhibition of HIV-1 reverse transcriptase associated ribonuclease H function

Simona Distinto; Francesca Esposito; Elias Maccioni; M. C. Cardia; Patrick Markt; Enzo Tramontano

XXIII Congresso Nazionale della Società Chimica Italiana | 2009

Tri-substituted thiazolines as promising scaffolds for the design of efficient COX inhibitors

Elias Maccioni; Stefano Alcaro; Francisco Orallo; M. C. Cardia; Simona Distinto; Maria Luisa Sanna; S. Vigo; Rita Meleddu; Francesco Ortuso; Daniela Secci; Matilde Yáñez; Adriana Bolasco

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