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Dive into the research topics where M. C. Gupta is active.

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Featured researches published by M. C. Gupta.


Clinical Research and Regulatory Affairs | 2016

An overview of the pharmacovigilance system in India

Niti Mittal; Rakesh Mittal; M. C. Gupta

Abstract Pharmacovigilance (PV) has witnessed several advancements throughout the world over the past few decades. This review provides an overview of the PV system in India, focusing on the current scenario, its development, the challenges faced, and the interventions suggested for its improvement. The Pharmacovigilance Program of India (PvPI) is playing a major role in gathering drug safety related data and adding it to the WHO database. PvPI fulfills the minimum requirements given by the WHO for any functional national Pharmacovigilance system. The Indian Pharmacopoeia Commission (IPC) is the national coordinating center under PvPI. PV in India relies mainly upon the spontaneous reporting of adverse drug events. The major challenge for PV in India is under-reporting. However, there is an improvement in the number of submitted reports after regular training and awareness programmes, which have been conducted by the IPC. The regular and periodic circulation of the ‘PvPI Newsletter’ by the IPC has also been instrumental in increasing awareness about PV amongst healthcare professionals and patients. The intensification of PV activities in India demands particular attention in health science curricula. Indeed, a change in mindset is necessary for prescribers, patients, regulatory agencies, and pharmaceutical companies.


Annals of Health and Health Sciences | 2016

Effect of Different Doses of Ascorbic Acid on Depression in Mice

Sarita Goyal; M. C. Gupta; Savita Verma

Ascorbic acid, commonly known as vitamin C, is a water-soluble antioxidant vitamin and has several therapeutic applications in a wide range of diseases. It is considered as a neuromodulator as it is highly concentrated in the brain and, as such, has a possible therapeutic relevance for the treatment of depression. This study was conducted to investigate the anti-depressant effect of ascorbic acid in forced swimming test (FST) and tail suspension test (TST) and the correlation between the dose and its antidepressant action. 24 male mice were selected and divided into 4 groups. Group I received normal saline. Group II received venlafaxine (0.048mg/g); Group III and Group IV received 0.065mg/g and 0.13 mg/g of ascorbic acid. All animals received drug treatment intraperitonially (i.p.), thirty minutes before the test. The results showed that ascorbic acid at a dose of 0.13mg/g, decreased immobility period and increased swimming as well as climbing, significantly, (p<0.01) in both TST and FST as compared to normal saline treated group. The effect of ascorbic acid, at the dosage of 0.13mg/g, was comparable to that of venlafaxine while at the dose of 0.065mg/g, the effect was lesser than that of the standard group. We concluded that higher dosages of ascorbic acid are effective to produce an antidepressant effect.


International journal of basic and clinical pharmacology | 2013

Toxic epidermal necrolysis induced by acetaminophen: a case report -

M. C. Gupta; Niti Mittal; Nishikant Sharma

Acetaminophen is a very commonly used analgesic and antipyretic drug across various age groups. Although mild to moderate cutaneous reactions have been reported quite frequently, serious reactions like Stevens –Johnson syndrome and Toxic epidermal necrolysis (TEN) are very rare. We report the case of a 10 year old child who had TEN after ingestion of tablet acetaminophen. This case report highlights the need to be critically aware of this rare and serious adverse effect of this commonly used over the counter drug.


Medical science | 2017

Student Perceptions about Pharmacology Teaching and Curriculum at a Tertiary Care Medical Institute of Haryana State, India-An Appraisal

Rakesh Mittal; M. C. Gupta; Vikas Nehra


Annals of Health and Health Sciences | 2016

An Appraisal of Integrated Student Seminar as a Teaching Learning Tool

Rakesh Mittal; Niti Mittal; M. C. Gupta


Pharmacologia | 2015

Anti-Inflammatory Effects of Morphine and Gabapentin, Alone and in Combination, in Rats

Sarita Goyal; M. C. Gupta; Savita Verma


International journal of basic and clinical pharmacology | 2015

Atracurium-induced anaphylaxis and angioedema: a case report

Jyoti Sharma; Savita Verma; M. C. Gupta


International journal of basic and clinical pharmacology | 2015

Lamotrigine-induced fulminant hepatic failure: an unusual presentation

M. C. Gupta; J. Khanna; R. Mathur; Niti Mittal


International journal of basic and clinical pharmacology | 2014

Fatal case of ciprofloxacin-induced toxic epidermal necrolysis.

Adesh D. Mishra; Prashant M. Urade; Niti Mittal; M. C. Gupta


International journal of basic and clinical pharmacology | 2014

Butterfly pattern hypopigmentation with antitubercular treatment

M. C. Gupta; Niti Mittal; Meenakshi Chaudhary

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Niti Mittal

Pt. B.D. Sharma PGIMS Rohtak

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