M. Caroline Burton

The Charlson Comorbidity Index Score as a Predictor of 30-Day Mortality After Hip Fracture Surgery

This study is a retrospective chart review to determine the association of Charlson Comorbidity Index (CCI), age, body mass index (BMI), and admission glucose with the incidence of postoperative 30-day mortality in older patients undergoing hip fracture surgery from January 1, 2000, to June 30, 2002. A total of 40 (8%) of 485 eligible patients died within 30 days after hip fracture surgery. The factors associated with 30-day mortality were age > 90 years (odds ratio [OR] = 2.74; confidence interval [CI] = 1.27-5.95; P = .012), BMI < 18.5 (OR = 3.98; CI 1.48-10.65; P = .006), and CCI ≥ 6 (OR = 2.6; CI = 1.20-5.65; P = .015). There was no relationship between admission glucose concentration and 30-day mortality. Advanced age, low BMI, and high CCI can be identified prospectively and are independently associated with postoperative 30-day mortality in older, chronically ill patients.

Eating disorders in the elderly.

BACKGROUND Eating disorders in the elderly are often overlooked. When they occur, significant morbidity and mortality result. In this study we review all existing literature on eating disorders in the elderly and provide practical guidelines for clinicians in recognizing and managing eating disorders in the elderly. METHODS A literature search using Medline, PubMed, Web of Knowledge, and PsychINFO revealed 48 published cases of eating disorders in people over the age of 50 years. RESULTS The mean age was 68.6 years (range 50-94), and the majority (88%) of cases were females. The majority (81%) of cases had anorexia nervosa, and 10% had bulimia nervosa. Late onset eating disorders were more common (69%) than early onset. Comorbid psychiatric conditions existed in 60%, most commonly major depression. Management with a combination of behavioral and pharmacologic interventions was most successful, although only 42% were treated successfully. Mortality was high (21%) secondary to the eating disorder and its complications. CONCLUSION Eating disorders do occur in the elderly and should be included in the differential diagnosis of unexplained weight loss in the elderly.

Do Timely Outpatient Follow-up Visits Decrease Hospital Readmission Rates?:

It is widely believed that timely follow-up decreases hospital readmissions; however, the literature evaluating time to follow-up is limited. The authors conducted a retrospective analysis of patients discharged from a tertiary care academic medical center and evaluated the relationship between outpatient follow-up appointments made and 30-day unplanned readmissions. Of 1044 patients discharged home, 518 (49.6%) patients had scheduled follow-up ≤14 days after discharge, 52 (4.9%) patients were scheduled ≥15 days after discharge, and 474 (45.4%) had no scheduled follow-up. There was no statistical difference in 30-day readmissions between patients with follow-up within 14 days and those with follow-up 15 days or longer from discharge (P = .36) or between patients with follow-up within 14 days and those without scheduled follow-up (P = .75). The timing of postdischarge follow-up did not affect readmissions. Further research is needed to determine such factors and to prospectively study time to outpatient follow-up after discharge and the decrease in readmission rates.

Gaining efficiency and satisfaction in the handoff process

BACKGROUND Handoffs, or transfers of patient care responsibility, occur frequently on hospitalist teams. The reliability and efficiency of the handoff process is a national and local concern. Most studies in the literature regard physicians-in-training. We studied the morning handoff process of hospitalist teams comprised of staff physicians and nurse practitioner and/or physician assistants. METHODS An improvement team observed morning handoffs. Four problems were identified: unpredictable start and finish times, inefficiency, poor environment (hallway noise and distracting in-room conversations), and poor communication. The team restructured the process and observed post-intervention behavior at 15 and 90 days. A participant-provider survey was conducted before and after the intervention regarding wasted time, total time-in-report, and satisfaction with the process. RESULTS Pre-intervention 60.5% of providers (23/38) believed morning handoff was performed in a timely fashion compared to 100% (15/15) post-intervention (P = 0.005). Average time spent in morning report was 11 minutes, compared to 5 minutes after the intervention (P < 0.0028). Pre-intervention 6.5 minutes were believed wasteful, compared to 0.5 minutes post-intervention (P < 0.0001). CONCLUSIONS This study identifies deficiencies in the handoff process that were addressed by enhancing the physical environment (smaller room, noise reduction, closed door), assigned seating (visual cues by table tent cards), non-clinicians providing printed materials, standardization of written updates, team times (consistent & precise daily time for each team report), culture change including deference of attention to team receiving report with opportunity for questions, and minimization of side conversations. This intervention package resulted in an improvement in satisfaction and timeliness of clinicians involved.

A Clinical Deterioration Prediction Tool for Internal Medicine Patients

Many early warning models for hospitalized patients use variables measured on admission to the hospital ward; few have been rigorously derived and validated. The objective was to create and validate a clinical deterioration prediction tool using routinely collected clinical and nursing measurements. Multivariate regression analysis was used to determine clinical variables statistically associated with clinical deterioration; subsequently, the model tool was retrospectively validated using a different cohort of medical inpatients. The Braden Scale (P = .01; odds ratio [OR] = 0.91; confidence interval [CI] = 0.84-0.98), respiratory rate (P < .01; OR = 1.08; CI = 1.04-1.13), oxygen saturation (P < .01; OR = 0.97; CI = 0.96-0.99), and shock index (P < .01; OR = 2.37; CI = 1.14-3.98) were predictive of clinical deterioration 2-12 hours in the future. When applied to the validation cohort, the tool demonstrated fair concordance with actual outcomes. This tool created using routinely collected clinical measurements can serve as a very early warning system for hospitalized medical patients.

Multiple admissions for alcohol withdrawal.

OBJECTIVE The objective was to identify risk factors for multiple admissions for alcohol withdrawal syndrome (AWS) in patients admitted to a general medicine service. METHODS A retrospective study was performed examining records of patients admitted for AWS between January 1, 2006 and December 31, 2008 to an academic tertiary referral hospital. Patients with a single admission were compared to patients with multiple admissions with respect to demographic and clinical variables. RESULTS Three hundred and twenty-two patients accounted for 788 admissions. Of the 322 patients, 142 (44%) had multiple admissions. Compared to patients with a single admission, patients with multiple admissions were more likely to have a high school education or less (p=0.0071), a higher Charlson comorbidity index score (p=0.0010), a positive urine drug screen for non-alcohol drug (p=0.0002), psychiatric comorbidity (p=0.0303) and a higher CIWA-Ar maximum total score (p<0.0001). CONCLUSION In patients with AWS, we identified demographic and clinical variables associated with multiple admissions to a general medicine service. Our results indicate areas for a targeted multidisciplinary and multispecialty approach at initial intervention, which is especially important given the high rates of recidivism in this patient population.

Clinical presentation and outcome of perioperative myocardial infarction in the very elderly following hip fracture surgery

BACKGROUND Patterns of clinical symptoms and outcomes of perioperative myocardial infarction (PMI) in elderly patients after hip fracture repair surgery are not well defined. METHODS A retrospective 1:2 case-control study in a cohort of 1212 elderly patients undergoing hip fracture surgery from 1988 to 2002 in Olmsted County, Minnesota. RESULTS The mean age was 85.3 ± 7.4 years; 76% female. PMI occurred in 167 (13.8%) patients within 7 days, of which 153 (92%) occurred in first 48 hours; 75% of patients were asymptomatic. Among patients with PMI, in-hospital mortality was 14.4%, 30-day mortality was 29 (17.4%), and 1-year mortality was 66 (39.5%). PMI was associated with a higher inpatient mortality rate (odds ratio [OR], 15.1; confidence interval [CI], 4.6-48.8), 30-day mortality (hazard ratio [HR], 4.3; CI, 2.1-8.9), and 1-year mortality (HR, 1.9; CI, 1.4-2.7). CONCLUSION Elderly patients, after hip fracture surgery, have a higher incidence of PMI and mortality than what guidelines indicate. The majority of elderly patients with PMI did not experience ischemic symptoms and required cardiac biomarkers for diagnosis. The results of our study support the measurement of troponin in postoperative elderly patients for the diagnosis of PMI, in order to implement in-hospital preventive strategies to reduce PMI-associated mortality.

Association of face‐to‐face handoffs and outcomes of hospitalized internal medicine patients

BACKGROUND Failures in communication at the time of patient handoff have been implicated as contributing factors to preventable adverse events. OBJECTIVE Examine the relationship between face-to-face handoffs and the rate of patient outcomes, including adverse events. DESIGN Retrospective cohort. SETTING A 1157-bed academic tertiary referral hospital. PATIENTS There were 805 adult patients admitted to general internal medicine services. INTERVENTION Retrospective comparison of clinical outcomes, including the rate of adverse events, of patients whose care was transitioned with and without face-to-face handoffs. MEASUREMENTS Rapid response team calls, code team calls, transfers to a higher level of care, death in hospital, 30-day readmission rate, length of stay, and adverse events (as identified using the Global Trigger Tool). RESULTS There was no significant difference with respect to the frequency of rapid response team calls, code team calls, transfers to a higher level of care, deaths in hospital, length of stay, 30-day readmission rate, or adverse events between patients whose care was transitioned with or without a face-to-face handoff. CONCLUSIONS Face-to-face handoff of patients admitted to general medical services at a large academic tertiary referral hospital was not associated with a significant difference in measured patient outcomes, including the rate of adverse events, compared to a non-face-to-face handoff. Additional study is needed to determine the qualities of patient handoff that optimize efficiency and safety.

Clinical phenomenology and mortality in Charles Bonnet syndrome

Background/Aim: Despite existing diagnostic criteria for Charles Bonnet syndrome (CBS), clinical manifestations vary greatly. We examined the clinical course and mortality of patients diagnosed with CBS. Methods: We conducted a retrospective chart review of patients with CBS. We collected demographic and clinical information and medical burden scores. Kaplan-Meier mortality curves were compared using log-rank test. Cox proportional hazard model was used for multivariate analysis and hazard ratio (HR). Mortality was compared to expected mortality from Minnesota population. Results: Seventy-seven patients with CBS had a mean age of 79.5 (standard deviation ± 13.0) and were predominantly Caucasian (97%) and female (73%). In all, 20 (26%) subsequently developed a dementia syndrome, most often Lewy body. A total of 46 (60%) deaths occurred with an average follow-up time of 33.0 months. Characteristics associated with mortality included older age (75-84 [HR 3.34, P = .029], >85 [HR 4.58, P = .007]) and renal disease (HR 3.39 with 95% confidence interval 1.31-8.80, P = .012). Medical burden scores were not associated with overall mortality. Mortality was high compared to Minnesota population (P < .0001). Conclusions: A large proportion of patients with CBS developed dementia, and there was a high mortality rate associated with older age and renal disease. Medical burden was not associated with mortality.

Munchausen syndrome by proxy: an adult dyad.

Munchausen syndrome by proxy (MSBP) is a form of abuse in which an individual deliberately produces or feigns clinical illness in a person under his or her care. Although well-documented in the child and adolescent literature, few case reports document MSBP with an adult proxy. We describe two patients: (1) Ms. A, a 21-year-old female, with recurrent episodes of polymicrobial bacteremia of unknown etiology, and (2) Ms. B, a 23-year-old female, with a history of a recurrent painful rash involving the pudenda. In the first case, medical staff found in the patient’s bed a syringe with an uncapped needle that contained a cloudy substance that grew the same organisms found in her blood. In the second case, the rash responded to topical treatment but dramatically worsened on the day of planned discharge. When the mother’s visitation was restricted and supervised, the rash immediately improved. Although typically reported in pediatric patients, MSBP should be considered in adult dyads when a patient’s medical problems do not respond as expected to therapy, and a caretaker appears overly involved or attention-seeking. Victims may suffer from “Stockholm syndrome,” holding the caretaker in high regard despite danger, even at risk of death. Munchausen syndrome by proxy (MSBP) is a mental illness characterized by a caregiver—the perpetrator—deliberately producing or feigning physical or psychological signs or symptoms in another person—the victim—who is under the perpetrator’s care. 1 The perpetrator’s psychological needs are met through the attention he or she receives during medical evaluations of their charge, even as induced conditions and iatrogenic complications can cause victims significant morbidity and even mortality. While MSBP is well described in the pediatric literature, 2 only seven cases have been reported with adult victims, 3‐9 and in three of these cases, the perpetrator was the same person. We believe that MSBP with an adult victim is underrecognized. We present two such cases with the objective