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Dive into the research topics where M. Cermolacce is active.

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Featured researches published by M. Cermolacce.


PLOS ONE | 2012

Neurocognition, Insight and Medication Nonadherence in Schizophrenia: A Structural Equation Modeling Approach

Laurent Boyer; M. Cermolacce; Daniel Dassa; Jessica Fernandez; Mohamed Boucekine; Raphaëlle Richieri; Florence Vaillant; Rémy Dumas; Pascal Auquier; Christophe Lançon

Objective The aim of this study was to examine the complex relationships among neurocognition, insight and nonadherence in patients with schizophrenia. Methods Design: Cross-sectional study. Inclusion criteria: Diagnosis of schizophrenia according to the DSM-IV-TR criteria. Data collection: Neurocognition was assessed using a global approach that addressed memory, attention, and executive functions; insight was analyzed using the multidimensional ‘Scale to assess Unawareness of Mental Disorder;’ and nonadherence was measured using the multidimensional ‘Medication Adherence Rating Scale.’ Analysis: Structural equation modeling (SEM) was applied to examine the non-straightforward relationships among the following latent variables: neurocognition, ‘awareness of positive symptoms’ and ‘negative symptoms’, ‘awareness of mental disorder’ and nonadherence. Results One hundred and sixty-nine patients were enrolled. The final testing model showed good fit, with normed χ2 = 1.67, RMSEA = 0.063, CFI = 0.94, and SRMR = 0.092. The SEM revealed significant associations between (1) neurocognition and ‘awareness of symptoms,’ (2) ‘awareness of symptoms’ and ‘awareness of mental disorder’ and (3) ‘awareness of mental disorder’ and nonadherence, mainly in the ‘attitude toward taking medication’ dimension. In contrast, there were no significant links between neurocognition and nonadherence, neurocognition and ‘awareness of mental disorder,’ and ‘awareness of symptoms’ and nonadherence. Conclusions Our findings support the hypothesis that neurocognition influences ‘awareness of symptoms,’ which must be integrated into a higher level of insight (i.e., the ‘awareness of mental disorder’) to have an impact on nonadherence. These findings have important implications for the development of effective strategies to enhance medication adherence.


Frontiers in Psychology | 2014

Temporal structure of consciousness and minimal self in schizophrenia

Brice Martin; Marc Wittmann; Nicolas Franck; M. Cermolacce; Fabrice Berna; Anne Giersch

The concept of the minimal self refers to the consciousness of oneself as an immediate subject of experience. According to recent studies, disturbances of the minimal self may be a core feature of schizophrenia. They are emphasized in classical psychiatry literature and in phenomenological work. Impaired minimal self-experience may be defined as a distortion of one’s first-person experiential perspective as, for example, an “altered presence” during which the sense of the experienced self (“mineness”) is subtly affected, or “altered sense of demarcation,” i.e., a difficulty discriminating the self from the non-self. Little is known, however, about the cognitive basis of these disturbances. In fact, recent work indicates that disorders of the self are not correlated with cognitive impairments commonly found in schizophrenia such as working-memory and attention disorders. In addition, a major difficulty with exploring the minimal self experimentally lies in its definition as being non-self-reflexive, and distinct from the verbalized, explicit awareness of an “I.” In this paper, we shall discuss the possibility that disturbances of the minimal self observed in patients with schizophrenia are related to alterations in time processing. We shall review the literature on schizophrenia and time processing that lends support to this possibility. In particular we shall discuss the involvement of temporal integration windows on different time scales (implicit time processing) as well as duration perception disturbances (explicit time processing) in disorders of the minimal self. We argue that a better understanding of the relationship between time and the minimal self as well of issues of embodiment require research that looks more specifically at implicit time processing. Some methodological issues will be discussed.


Journal of Affective Disorders | 2012

Parieto-temporal alpha EEG band power at baseline as a predictor of antidepressant treatment response with repetitive Transcranial Magnetic Stimulation: A preliminary study

Jean-Arthur Micoulaud-Franchi; Raphaëlle Richieri; M. Cermolacce; Anderson Loundou; Christophe Lançon; Jean Vion-Dury

BACKGROUND The aim of this preliminary study was to determine the predictive value of absolute alpha band power measured during the rest EEG eyes closed task for responses to 20 sessions of high frequency repetitive transcranial stimulation (rTMS) in the left dorsolateral prefrontal cortex in patients with pharmacoresistant major depressive episode. METHODS 13 major depressive disorders (8 males) and 8 bipolar disorders (6 males) were included (mean age 58years). Spearman correlations between pretreatment alpha band power in height regions of analysis and absolute improvement in Beck Depression Inventory Short Form (ΔBDI-SF) were analyzed. The predictive value of alpha band power for classifying patients as responders and non-responders to rTMS was determined using Receiver Operating Characteristic (ROC) curve. RESULTS Spearman correlation analysis revealed that ΔBDI-SF correlated significantly and negatively with alpha band power on the right (r=-.673, p=.001) and left parieto-temporal regions (r=-.638, p=.002). The area under the ROC curve for the right parieto-temporal was .815, p=.0037. The cut-off point that maximized both sensitivity and specificity was 1.49μV. Sensitivity, specificity, positive and negative predictive values were 100, 66, 80, 100% respectively. LIMITATIONS The population was small and lacked homogeneity concerning affective disorders (unipolar and bipolar disorder). The use of a self-rating subjective scale (BDI-SF) to measure the severity of depression could be criticized. CONCLUSIONS Pretreatment alpha band power on parieto-temporal regions could be a predictor for response to rTMS in patients with homogenous demographic/clinical features. The association between electrical activity and the perfusion under each electrode need to be examined.


Neurophysiologie Clinique-clinical Neurophysiology | 2012

Vers une nouvelle déclinaison de la neurophysiologie clinique en psychiatrie : le neurofeedback par imagerie par résonance magnétique fonctionnelle appliqué aux dysfonctions des processus émotionnels

Jean-Arthur Micoulaud-Franchi; E. Fakra; M. Cermolacce; Jean Vion-Dury

Emotions color in a singular way our everyday life and constitute important determinants of human cognition and behavior. Emotional regulation is an essential process involved in neuropathophysiology and therapeutic efficacy in many psychiatric disorders. Yet, traditional psychiatric therapeutic has focused on symptomatic rather than neurophysiological criteria. Therefore, it was proposed to teach patients to modify their own brain activity directly, in order to obtain a therapeutic effect. These techniques, which are named neurofeedback, were originally developed using electroencephalography. Recent technical advances in fMRI enable real-time acquisition, and open opportunities to its utilization in neurofeedback. This seems particularly interesting in emotion regulation, which, at a neurofunctional level, lies on cortico-limbic pathways that, in great parts, were previously identified by traditional fMRI paradigms. This emotion regulation plays a central role in the etiopathogeny psychiatric, especially depressive and anxious, disorders. It is possible to devise new therapeutic strategies and research approach for addressing directly the neurophysiological processes of emotion regulation by integrating the neurofunctional activities of a subject. These prospects seem to be in line with the neurophenomenology project, which proposes to establish a link between subjective experiences and objective neurophysiological measures.Emotions color in a singular way our everyday life and constitute important determinants of human cognition and behavior. Emotional regulation is an essential process involved in neuropathophysiology and therapeutic efficacy in many psychiatric disorders. Yet, traditional psychiatric therapeutic has focused on symptomatic rather than neurophysiological criteria. Therefore, it was proposed to teach patients to modify their own brain activity directly, in order to obtain a therapeutic effect. These techniques, which are named neurofeedback, were originally developed using electroencephalography. Recent technical advances in fMRI enable real-time acquisition, and open opportunities to its utilization in neurofeedback. This seems particularly interesting in emotion regulation, which, at a neurofunctional level, lies on cortico-limbic pathways that, in great parts, were previously identified by traditional fMRI paradigms. This emotion regulation plays a central role in the etiopathogeny psychiatric, especially depressive and anxious, disorders. It is possible to devise new therapeutic strategies and research approach for addressing directly the neurophysiological processes of emotion regulation by integrating the neurofunctional activities of a subject. These prospects seem to be in line with the neurophenomenology project, which proposes to establish a link between subjective experiences and objective neurophysiological measures.


Neurophysiologie Clinique-clinical Neurophysiology | 2011

Électrophysiologie et vulnérabilité schizophrénique : la composante P300 comme endophénotype candidat ?

M. Cermolacce; J.-A. Micoulaud; Jean Naudin; Jean Vion-Dury

Research on early stages of schizophrenia aims to provide early, objective, and stable markers of vulnerability. In this review, we first briefly describe the notion of such markers, or endophenotypes, notably in terms of stability, specificity and heritability. Among other empirical approaches, event-related potentials (ERPs) have been recently considered as putative endophenotypes. The N400 component is an event-related brain potential classically elicited during semantic processing, as suggested by a growing body of empirical studies with a large variety of paradigms. We provide here a short account of its typical descriptions and the interpretations of its functional significance. Then we describe the main current results about schizophrenic alterations of the N400 component. Two levels of semantic processing (automatic spreading and controlled mechanisms) are disturbed in schizophrenia, even if the underlying mechanisms remain unclear or discussed. Several controversial issues may also need further research, such as the influence of symptomatology and evolution of schizophrenia. Another crucial topic concerns the putative schizophrenic specificity, and only little is known about possible alterations of N400 in affective disorders. We discuss the notion of heritability, mainly explored in current literature among people with schizotypal personality. Finally, even if N400 studies contribute to a better understanding of linguistic disturbances in schizophrenia, it appears difficult to consider the N400 component as a relevant schizophrenic endophenotype, given the current paucity of results on its stability, its heritability (clinical and genetic vulnerability) and its schizophrenic specificity.


Schizophrenia Research | 2015

Elevated C-reactive protein is associated with sensory gating deficit in schizophrenia

Jean-Arthur Micoulaud-Franchi; Mélanie Faugere; Laurent Boyer; Guillaume Fond; Raphaëlle Richieri; Catherine Faget; M. Cermolacce; Pierre Philip; Jean Vion-Dury; Christophe Lançon

Sensory and cognitive impairments and inflammatory processes are contributing factors to the pathogenesis of schizophrenia. A previous study found that an elevated CRP level (≥5mg/L) was associated with higher cognitive impairments in schizophrenia. We aimed to investigate the association between an elevated CRP level and sensory impairments defined by a sensory gating deficit (abnormal P50 suppression) in 55 outpatients. Fifteen patients (27.3%) had an elevated CRP level that was associated with higher rate of sensory gating deficit (60% vs. 12.5%, p<0.001). This is the first study suggesting a relationship between sensory gating deficit and inflammatory processes in schizophrenia.


Biological Psychology | 2015

Sensory gating in adult with attention-deficit/hyperactivity disorder: Event-evoked potential and perceptual experience reports comparisons with schizophrenia

Jean-Arthur Micoulaud-Franchi; Florence Vaillant; Régis Lopez; Pauline Péri; Alexandra Baillif; Laura Brandejsky; Marie Laure Steffen; Laurent Boyer; Raphaëlle Richieri; M. Cermolacce; Stéphanie Bioulac; Mitsuko Aramaki; Pierre Philip; Christophe Lançon; Jean Vion-Dury

BACKGROUND In daily life, adults with attention-deficit/hyperactivity disorder (ADHD) report abnormal perceptual experiences that can be related to sensory gating deficit. This study investigated and compared P50 suppression (a neurophysiological measure of sensory gating) and perceptual abnormalities related to sensory gating deficit in ADHD and schizophrenias patients. METHODS Three groups were compared: 24 adults with ADHD, 24 patients with schizophrenia and 24 healthy subjects. The Sensory Gating Inventory (SGI), a validated self-report questionnaire, was used to measure perceptual abnormalities related to sensory gating deficit. P50 suppression was measured by P50 amplitude changes in a dual-click conditioning-testing auditory event-related potential procedure. RESULTS Adults with ADHD had significantly higher scores on the SGI and significantly lower P50 suppression than healthy subjects. These deficits were similar to those found in patients with schizophrenia. A correlation was found between both the SGI and P50 suppression data in adults with ADHD and patients with schizophrenia. DISCUSSION The findings confirm previous results found in patients with schizophrenia. Moreover, adults with ADHD, similar to patients with schizophrenia, had abnormal P50 suppression and reported being flooded with sensory stimuli. Abnormal neurophysiologic responses to repetitive stimuli gave rise to clinically abnormal perceptions.


Psychiatry Research-neuroimaging | 2011

Categorization and timbre perception of environmental sounds in schizophrenia

Jean-Arthur Micoulaud-Franchi; Mitsuko Aramaki; Adrien Merer; M. Cermolacce; Sølvi Ystad; Richard Kronland-Martinet; Jean Vion-Dury

Perception of environmental sounds from impacted materials (Wood, Metal and Glass) was examined by conducting a categorization experiment. Stimuli consisted of sound continua evoking progressive transitions between material categories. Results highlighted shallower response curves in subjects with schizophrenia than healthy participants, and are discussed in the framework of Signal Detection Theory and in terms of impaired perception of specific timbre features in schizophrenia.


Psychiatry Research-neuroimaging | 2016

Self-disorders in individuals with attenuated psychotic symptoms: Contribution of a dysfunction of autobiographical memory

Fabrice Berna; Anja S. Göritz; Johanna Schröder; Brice Martin; M. Cermolacce; Mélissa C. Allé; Jean-Marie Danion; Christine Cuervo-Lombard; Steffen Moritz

Patients with schizophrenia and people with subclinical psychotic symptoms have difficulties getting a clear and stable representation of their self. The cognitive mechanisms involved in this reduced clarity of self-concept remain poorly understood. The present study examined whether an altered way of thinking or reasoning about ones past may account for the reduced clarity of self-concept in individuals with attenuated psychotic symptoms (APS). An online study comprising 667 participants examined the capacity to give a meaning to past events and to scrutinize autobiographical memory to better understand him/herself. Our results showed that in this sample, individuals with APS (n=49) have a lower clarity of self-concept and a higher tendency to scrutinize autobiographical memory than controls subjects (n=147). A mediation analysis performed on the full sample revealed that the relation between APS and clarity of self-concept was mediated by a tendency to scrutinize autobiographical memory. Our results suggest that the weakness of self-concept, which increases with the intensity of psychotic symptoms, may be related to an altered function of autobiographical memory, so that examining past events may fail to sustain a stable and clear representation of the self when psychotic symptoms increase.


Journal of Affective Disorders | 2014

Natural speech comprehension in bipolar disorders: An event-related brain potential study among manic patients

M. Cermolacce; Mélanie Faugere; Jean-Arthur Micoulaud-Franchi; Raoul Belzeaux; Muriel Maurel; Jean Naudin; Jean-Michel Azorin; Jean Vion-Dury

BACKGROUND Thought and language disturbances are crucial clinical features in Bipolar Disorders (BD), and constitute a fundamental basis for social cognition. In BD, clinical manifestations such as disorganization and formal thought disorders may play a role in communication disturbances. However, only few studies have explored language disturbances in BD at a neurophysiological level. Two main Event-Related brain Potentials (ERPs) have been used in language comprehension research: the N400 component, elicited by incongruous word with the preceding semantic context, and the Late Positive Component (LPC), associated with non-specifically semantic and more general cognitive processes. Previous studies provided contradictory results regarding N400 in mood disorders, showing either preserved N400 in depression or dysthymia, or altered N400 in BD during semantic priming paradigm. The aim of our study was to explore N400 and LPC among patients with BD in natural speech conditions. METHODS ERPs from 19 bipolar type I patients with manic or hypomanic symptomatology and 19 healthy controls were recorded. Participants were asked to listen to congruous and incongruous complete sentences and to judge the match between the final word and the sentence context. Behavioral results and ERPs data were analyzed. RESULTS At the behavioral level, patients with BD show worst performances than healthy participants. At the electrophysiological level, our results show preserved N400 component in BD. LPC elicited under natural speech conditions shows preserved amplitude but delayed latency in difference waves. LIMITATIONS Small size of samples, absence of schizophrenic group and medication status. CONCLUSIONS In contrast with the only previous N400 study in BD that uses written semantic priming, our results show a preserved N400 component in ecological and natural speech conditions among patients with BD. Possible implications in terms of clinical specificity are discussed.

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Jean Vion-Dury

Aix-Marseille University

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E. Fakra

Aix-Marseille University

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M. Adida

Centre national de la recherche scientifique

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Arthur Kaladjian

University of Reims Champagne-Ardenne

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