M. Elawad

P567 Allogeneic haematopoietic stem cell transplant (HSCT) for paediatric Crohn's disease: A case report

Conclusions: We developed a matrix-based prediction tool to aid physicians in optimizing therapeutic decisions. After stringent selection of predictors only age at first IFX, BMI and previous surgery were withheld. A younger age has been associated with primary response in several independent cohorts. BMI is also known to influence response and this is assigned to the weight based dosing of IFX. Previous surgery has also been associated with PNR and might reflect more refractory disease. The next step is to validate this matrix in an independent cohort and to construct a matrix-prediction tool for secondary loss of response.

P155 Quality Improvement Tool: 3 year outcome

Among caregivers female sex, residence in rural areas, increased disease duration and disease severity were significantly correlated with low SF-36 mental domains scores whilst high educational level and employment status were significantly correlated with higher SF-36 score in the domains of emotional role functioning and of mental health. Conclusions: 1. Family caregivers of IBD patients have impaired QoL; 2. Gender, Place of residence, Educational level, Employment status and Disease duration and severity has significant effect on caregivers’ QoL; 3. Interventions targeting caregiver’s mental health are expected to improve their QoL.

P519 Efficacy of Adalimumab in children and adolescents with moderate/ severe ulcerative colitis

co-morbidities, disease severity, surgical operations, gender, steroid therapy and treatment response were related to VTE. Results: 2668/3049 (87.5%) patients were given prophylactic heparin. 66/3049 (2.2%) patients experienced VTE during their admission. The rate of VTE amongst heparinised patients, 2.2% (59/2668), did not differ significantly when compared to a rate of 1.8% (7/381) within the population who didn’t receive prophylaxis (p < 0.8). VTE was associated with surgery: 39.4% (26/66) of patients with VTE underwent surgery compared with surgery in 26.2% (781/2983) without VTE (P< 0.02). Of these 26 surgical patients within the VTE population, 4 of these patients’ VTE were post-operative. When patients undergoing elective surgery are excluded VTE is associated with co-morbidity: 46.0% (23/50) of the VTE population compared to 32.4% (810/2504) in the nonVTE population (p < 0.03). There was no association of VTE with disease severity or the use of steroids. Conclusions: Although there was no difference in the frequency of VTE in patients given or not given heparin the numbers of VTE within this group are small. This analysis does however demonstrate that patients with co-morbidity and those undergoing surgery are at higher risk of VTE. Additional measures to prevent VTE should be considered in these patients such as a combination of heparin and compression stockings. All IBD patients admitted to hospital should continue to receive prophylactic subcutaneous heparin.