M. Földi

Increased sensitivity to pentobarbital in rats fed a diet lacking flavonoids.

Pentobarbital-sensitivity is highly increased in rats fed a diet lacking flavonoids; sleeping time was found to be increased by 42 and 30% as compared with rats fed a normal diet. These studies confirm our previous statement according to which for the rat, benzopyrones are vitamins.

Treatment of experimental vasogenic cerebral edema with benzopyrones.

Vasogenic cerebral edema was induced in rabbits by cold injury. Benzopyrone treatment, started 15 min after freezing, significantly reduced both brain edema and the increased permeability of the blood-brain barrier. On the other hand benzopyrone-treatment was without any effect in cytotoxic brain edema induced in rats by triethyl tin poisoning.

The Treatment of Experimental Lymphedema

It has been shown previously, by plethysmographic measurements, that experimental lymphedema can be treated successfully by administration of coumarin and by massage. The present study confirms this f

Lymphatic porosity as a consequence of complex vitamin B deficiency in the rat

Lymphatic porosity was produced by feeding rats a diet, lacking from the vitamins of the B group. Coumarintroxerutin (Venalot®) treatment has been found to prevent this abnormality. Pathophysiologic a

Lymphostase und Vitamine

In the first part of the present work, experimental data are produced showing that a correlation does exist between lymphostasis and vitamins, both in connection with lymphoedema of the subcutaneous t

Permeability of the blood-brain-barrier in lymphostatic encephalopathy combined with complex vitamin B deficiency. The protective effect of vitamin (factor) P treatment

Die bereits bekannte Permeabilitätszunahme der Blut-Hirnschranke bei der lymphostatitischen Enzephalopathie wurde mittels einer neuen Methode bestätigt: i.v. infundiertes PVP, mit einem Molekulargewicht von 40.000, drang bei normalen Kontrollratten in die Hirnsubstanz nicht ein; bei Tieren mit einer lymphostatischen Enzephalopathie war PVP in der Hirnsubstanz nachweisbar. Eine komplexe B-Avitaminose führt ebenfalls zum Eindringen von PVP in die Hirnsubstanz; eine Kombination zwischen lymphostatischer Enzephalopathie und komplexer B-Avitaminose hat eine Addition der Permeabilitätsstörung zur Folge. Zwei in die «Vitamin P-Familie» gehörende Stoffe, Cumarin und Troxerutin, übten einen weitgehenden protektiven Effekt gegen die Zunahme der Permeabilität der Blut-Hirnschranke aus.

Effect of External Lymph Drainage and of Coumarin Treatment on Dextran Edema

A significant protective effect is afforded against dextran oedema by external thoracic duct cannulation; the protective effect of coumarin is even more pronounced. The theoretical background of these