M. Goncalves
Centre national de la recherche scientifique
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Publication
Featured researches published by M. Goncalves.
Pharmaceutical Research | 2005
M. Goncalves; Karine Estieu-Gionnet; Thomas Berthelot; Georges Laïn; Mireille Bayle; Xavier Canron; N. Betz; Andreas Bikfalvi; Gérard Déléris
PurposeAngiogenesis is a key event in tumor growth and metastasis, chronic inflammatory disease, and cardiovascular disease. It is controlled by positive and negative regulators, which include vascular endothelial growth factor (VEGF) as the most active of these. VEGF/VEGF receptors are important targets not only for therapy but also for imaging. Based on the structural study of VEGF, we developed a novel cyclopeptide (cyclo-VEGI) that exhibits powerful antitumor properties. We herein report the design of novel molecules derived from cyclo-VEGI as potential targeting agents in cancer and other angiogenesis-related diseases.MethodsWe performed selective chemical modification of the most active VEGF-derived cyclopeptide (cyclo-VEGI). Original hydrophilic linkers were synthesized and coupled to cyclo-VEGI. These reactions provide nanocarriers for delivery. The inhibitory effect of the different compounds on VEGF binding was evaluated in competition assays with 125I-VEGF. A fluorescent cyclo-VEGI peptide was synthezised to assess direct binding and internalization of cyclo-VEGI.ResultsChemical modifications of cyclo-VEGI do not diminish the biological activity of cyclo-VEGI as measured in competition assays; in fact, it is even increased. Moreover there is a strong cellular accumulation of the fluorescent-labeled cyclo-VEGI. Conjugates synthesized in this study may be useful leads to design delivery systems for targeting approaches in cancer and other angiogenesis-related diseases.ConclusionThe modified cyclo-VEGIs may have a wide range of applications and represent a useful tool to develop delivery/carrier systems for therapeutic targeting or imaging.
Journal of Biological Chemistry | 2003
Lior Zilberberg; Svetlana Shinkaruk; Olivier Lequin; Benoît Rousseau; Martin Hagedorn; Francesco Costa; Dario Caronzolo; Maurice Balke; Xavier Canron; Odile Convert; Georges Laïn; Karine Gionnet; M. Goncalves; Mireille Bayle; Lorenzo Bello; Gérard Chassaing; Gérard Déléris; Andreas Bikfalvi
Analyst | 2006
Cyril Petibois; Karine Gionnet; M. Goncalves; Annie Perromat; Michel Moenner; Gérard Déléris
Tetrahedron | 2005
M. Goncalves; Karine Estieu-Gionnet; Georges Laïn; Mireille Bayle; N. Betz; Gérard Déléris
Tetrahedron | 2006
Thomas Berthelot; M. Goncalves; Georges Laïn; Karine Estieu-Gionnet; Gérard Déléris
Reactive & Functional Polymers | 2008
M.-Cl. Clochard; Olivia Cuscito; Thomas Berthelot; N. Betz; Carla Bittencourt; J.-J. Pireaux; M. Goncalves; K. Gionnet; Gérard Déléris
Europace | 2017
J. Mesquita; Am. Ferreira; S. Guerreiro; J. Abecasis; C. Saraiva; G. Rodrigues; M. Goncalves; D. Bento; F. Costa; Pedro Carmo; F. Morgado; Diogo Cavaco; Pedro Adragão; M. Mendes
Europace | 2017
Nélson Vale; Pedro Carmo; S. Madeira; E. Vitorino; M. Goncalves; G. Rodrigues; F. Costa; Diogo Cavaco; F. Morgado; Pedro Adragão
Europace | 2017
J. Mesquita; Am. Ferreira; S. Guerreiro; J. Abecasis; C. Saraiva; G. Rodrigues; M. Goncalves; D. Bento; F. Costa; Pedro Carmo; F. Morgado; Diogo Cavaco; Pedro Adragão; M. Mendes
Europace | 2017
Nélson Vale; Pedro Carmo; M Neto; Diogo Cavaco; M. Goncalves; G. Rodrigues; F. Costa; F. Morgado; Pedro Adragão