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Dive into the research topics where M. Kh. Dzhafarov is active.

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Featured researches published by M. Kh. Dzhafarov.


Russian Chemical Bulletin | 2014

Synthesis and biological activity of new avermectin 5-O- and 4″-O-acyl derivatives

I. V. Zavarzin; E. S. Kuleshova; E. I. Chernoburova; M. A. Shchetinina; A. V. Kolobov; V. V. Plakhtinskii; M. Kh. Dzhafarov

Acylation of avermectin B1 with vicinal 1,2-dicarboxylic acid anhydrides leads only to 5-O-acyl derivatives in high yields. Avermectin 4″-O-acyl derivatives were obtained under similar conditions from avermectin B1 5-O-TBS-derivatives in good yields. The compounds obtained are of interest as antiparasitic agents.


Russian Chemical Bulletin | 2016

Synthesis of esters of bile acids and avermectin B1

E. I. Chernoburova; E. S. Polyukhova; M. A. Shchetinina; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

Esters of bile acids and avermectin B1 were obtained for the first time by the reaction of avermectin B1 with bile acid anhydrides.


Russian Chemical Bulletin | 2016

Synthesis of 5,4″-di-O-succinoylavermectin B1

E. I. Chernoburova; M. A. Shchetinina; A. A. Zharov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

A reaction of avermectin B1 with succinic anhydride at ultrahigh pressure (10 kbar) gave previously unavailable 5,4″-di-O-succinoylavermectin B1, which is of interest as potential antiparasitic agent.


Russian Chemical Bulletin | 2016

Reaction of 5- O -succinoylavermectin B 1 with alkylating agents

E. I. Chernoburova; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

A reaction of 5-O-succinoylavermectin B1 with alkylating agents, namely phenacyl halides, bromoacetanilides, and benzyl bromides, was studied. Esters of 5-O-succinoylavermectin B1 were obtained for the first time, which are of interest as potential antiparasitic agents.


Russian Chemical Bulletin | 1993

SYNTHESIS OF 1,2,4-SUBSTITUTED HEXAHYDROPYRIDAZINES AND X-RAY STRUCTURAL INVESTIGATION OF 4-HYDROXYIMINO-2-METHYL-1-PHENETHYLHEXAHYDROPYRIDAZINE

A. Kh. Khanamiryan; A. L. Gyul'budagyan; P. S. Vartanyan; M. Kh. Dzhafarov; Yu. T. Struchkov

A series of new 1,2,4-substituted hexahydropyridazines was prepared in order to evaluate qualitatively and quantitatively the role and influence of substituents on the biological activity of this system. An X-ray structural investigation of 4-hydroxyimino-2-methyl-1-phenethylhexahydropyridazine was performed. The compounds considered exhibit moderate local anesthetic, antihistaminic, and anticonvulsive activity.


Russian Chemical Bulletin | 2018

Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin

M. A. Shchetinina; E. I. Chernoburova; N. G. Kolotyrkina; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

Treatment of ivermectin with sulfuric acid–acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.


Russian Chemical Bulletin | 2018

Synthesis of ivermectin-4″,5-diyl[bis(N-methylcarbamate)]

Alexander N. Blinnikov; E. I. Chernoburova; N. G. Kolotyrkina; M. A. Shchetinina; V. A. Lishchuk; K. L. Ovchinnikov; A. V. Kolobov; M. Kh. Dzhafarov; F. I. Vasilevich; I. V. Zavarzin

New ivermectin-4″,5-diyl[bis(N-methylcarbamate)] was synthesized by the MoO2Cl2(DMF)2-catalyzed reaction of ivermectin with methyl isocyanate. The synthesized compound could find application as antiparasitic agent.


Russian Chemical Bulletin | 2016

Functionalization of NH-unsubstituted androstano[17,16-d]pyrazoles. Synthesis of 2-arylamino-2-thioxoacetylandrostano[17,16-d]pyrazoles

V. V. Chertkova; E. I. Chernoburova; M. Kh. Dzhafarov; A. Yu. Tyurin; Yu. A. Volkova; F. I. Vasilevich; I. V. Zavarzin

An approach to the synthesis of earlier unknown androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring has been suggested. The method is based on the reaction of NH-unsubstituted androstano[17,16-d]pyrazole with chloroacetyl chloride with subsequent involvement of the obtained N-chloroacetylpyrazole into the reaction with elementary sulfur in the presence of aromatic amines. The synthesized androstano[17,16-d]pyrazoles containing a monothiooxamide fragment at the nitrogen atom of the pyrazole ring exhibit high antiparasitic activity.


Russian Chemical Bulletin | 1993

New variants in the total synthesis of 14?-hydroxy-17?,R-8?,9?-estradiol derivatives

S. Kh. Karamyan; S. N. Ananchenko; M. Kh. Dzhafarov

Two procedures were developed for the synthesis of 17α-alkyl-8α,9β-estra-1,3,5(10)-triene-3,14β,17β-triols from 3-methoxy-estra-1,3,5(10),8(9),14(15)-pentaene-17-one (1) using photosensitized oxidation by atmospheric oxygen or ionic hydrogenation in the presence of oxygen. It was shown that 17α-hexynyl-8α,9β-estra-1,3,5(10)-triene-3,14β,17β-triol (23) and its 3-methoxy derivative (26) inhibit K+,Na+-ATPase, with inhibition degree increasing on introduction of an oxygen-containing substituent into position 17. For the first time steroids were found with α2-adrenoblocking action.


Russian Chemical Bulletin | 1991

Isomerization of 14-hydroxy-17-ketosteroids: New examples of two-centered inversion of the C/D ring fusion and X-ray diffraction structural analysis of d,ℓ-3-methoxy-14β-hydroxy-8β, 9α-estra-1,3,5(10)-trien-17-one

M. Kh. Dzhafarov; Sergey V. Lindeman; Yuri T. Struchkov; Kh. Karamyan; S. N. Ananchenko

Abstractd,ℓ-3-Methoxy-14β-hydroxy-8α,9β-estra-1,3,5(10)-trien-17-one (I) undergoes two-centered isomerization in alkaline medium to d,ℓ-3-methoxy-14β-hydroxy-8β,9α-estra-1, 3,5(10)-trien-17-one (II) in 70% yield. Under analogous conditions, natural isomer (II) is converted into synthetic isomer (I) in 20% yield. The crystalline and molecular structure of isomer (II) was established.

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E. I. Chernoburova

Russian Academy of Sciences

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I. V. Zavarzin

Russian Academy of Sciences

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M. A. Shchetinina

Russian Academy of Sciences

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S. N. Ananchenko

Russian Academy of Sciences

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N. G. Kolotyrkina

Russian Academy of Sciences

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S. Kh. Karamyan

Russian Academy of Sciences

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Yu. T. Struchkov

A. N. Nesmeyanov Institute of Organoelement Compounds

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A. A. Zharov

Russian Academy of Sciences

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A. Yu. Tyurin

Russian Academy of Sciences

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