M. Lewis

Linkage between the Colton blood group locus and ASSP11 on chromosome 7

In an attempt to assign the Colton blood group locus (CO) we have successfully revisited chromosome 7. CO is linked to the argininosuccinate synthetase pseudogene 11 locus (ASSP11) with z = 5.79 at theta = 0.07 for combined paternal and maternal meioses. We propose a 7p position for CO.

Absorption of red cells from the peritoneal cavity of an hydropic twin.

A pair of monozygotic erythroblastotic twins, one with hydrops, the other without, were treated by intrauterine transfusion. The twins had a monochorionic, diamniotic placenta with gross surface vascular anastomoses; at birth their circulating blood was of a single composition. The composition established that the presence of ascites per se does not inhibit absorption of blood from the peritoneal cavity.

On the Antigen Goa and the Rh System1

Summary. A study, primarily based on two negro families in which the propositae were D‐positive and had produced ‘anti‐D’, make it certain that the antigen called Goa (Gonzales) is part of the D complex of the Rh system and that it is characteristic of those people who make up Category IV of Tippett and Sanger.

The Swann Phenotype 700:4,‐41; Genetic Studies

Abstract. Serological analysis of the red cells from members of a large French‐Canadian kindred proved that the Swa antigen is not part of the P1, Dombrock or Yt blood group systems. A linkage analysis of the SW blood group locus in relation to 27 other loci indicates that SW is not closely linked to ABO, ACP1, ADA, AK1, C3, D2S5, DO, ESD, F13A, FY, GLO1, GPT, HP, IGHG, JK, LU, MYCL, P1, PGP, PGM1, PLG, RH or YT. By inference the study also allows exclusion of Swa from the Landsteiner‐Wiener, Radin and Scianna blood group systems and exclusion of SW from the p22.1 to p34 segment of chromosome 1.

Evidence that SE is distal to LU on chromosome 19q

Analysis of a family informative for chromosome 19 loci establishes that the Lutheran blood group locus (LU) lies between the third component of human complement (C3) and the secretor loci (SE). Previously published lod scores for C3:LU are increased from 2.94 to 3.80. The linkage relationships (ẑ and Ô) between C3, LU, and SE are examined, and the proposed order and approximate genetic distances are determined to be: pter —C3 ‐ 10.6cM ‐ cen ‐ 7.4cM ‐ LU ‐ 9cM ‐ SE— qter.

Exclusion of Unassigned Blood Group System Loci from the Regulator of Complement Activation Gene Cluster on Chromosome 1q32

Abstract. Genetic linkage analyses of the blood group system loci CO, DI, DO, KEL and YT in relation to F13B indicate that these loci are not members of the RCA gene cluster on chromosome 1q32. The data are presented to finalize the exclusion of the DAF carried red cell antigens from all of the 17 established blood group systems.

A Family in which the Targett (Rh: 40) Antigen is Carried with (‐D‐)

Abstract. Statistical and serological evidence supporting the assignment of Tar to the Rh blood group system is presented. The association of the presence of the Tar antigen with a weak expression of D is confirmed, and the rare Rh complex (‐D‐) Tar ‐positive described. The expression of the Tar antigen is influenced by the Rh complex with which it is associated.

A New Rare Blood Group Antigen - ‘Mit’: Probable Genetic Relationship with the MNSs Blood Group system

Abstract. A new low incidence blood group antigen ‘Mit’, immunization to which may cause hemolytic disease of the newborn, is described. It is not part of the ABO, Duffy, Kidd, Rh or Yt blood group systems. Positive lods of +2.41 at Θ = 0.00 indicate that the odds are 256 to 1 that ‘Mit’ is either part of the MNSs system or governed by a locus closely linked to MN and Ss.

Distinction of the Glycophorin C Locus from the Diego, Dombrock and Yt Blood Group Loci

Abstract. DNA samples from families informative for the Diego (DI), Dombrock (DO) and Yt (YT) blood group loci were analyzed with a cDNA probe defining a Taq I polymorphism at the glycophorin C locus (GYPC). Recombination between GYPC and DI, DO and YT occurs. Hence GYPC is differentiated from all established blood group system loci.

A Private Red Cell Antigen, Jones, Causing Haemolytic Disease of the Newborn

Abstract. Two previously unpublished low‐incidence antigens, Jones and Hol., are identical. The antigen is a dominant, autosomally inherited character that segregates independently from the loci for the ABO, MNS, Duffy and Yt blood group systems and is different from previously published infrequent antigens. The antigen is apparently unaffected by enzyme treatment and is well developed on red cells of neonates. The antibody reacts best by indirect antiglobulin testing, is IgG and has caused haemolytic disease of the newborn. This private blood group antigen, named Jones, has been assigned the ISBT number 700047.