M. Margaret Dolcini

Extramarital sex and HIV risk behavior among US adults: results from the National AIDS Behavioral Survey.

Data from the National AIDS Behavioral Survey were used to examine the social distribution of extramarital sex and risk for human immunodeficiency virus (HIV) infection among married individuals in the United States. Of 1686 married respondents living across the United States, 2.2% reported extramarital sex; of 3827 married respondents living in 23 urban areas with large Hispanic or African-American populations, 2.5% reported having sexual partners outside marriage. The data indicate that the correlates of extramarital sex varied by race/ethnicity. Low levels of condom use were found among people reporting extramarital sex (8% to 19% consistent users).

Demographic Characteristics of Heterosexuals with Multiple Partners: The National AIDS Behavioral Surveys

In a study of risk behavior among heterosexuals, 9% of a national sample and 12% of a sample drawn from high-risk cities report having two or more sexual partners in the year before the survey. In both samples, sex with multiple partners is most common among men, younger people and the unmarried. Multivariate analyses show that racial and ethnic differences in the proportion of respondents with multiple partners vary by marital status. The results indicate that many heterosexuals are failing to protect themselves against sexually transmitted diseases: Among respondents with multiple partners, only 18% of men and 22% of women always use condoms with their primary partner, and 28% of men and 32% of women always use them with secondary partners. These proportions do not increase significantly with the number of partners; in general, almost half of men and women with multiple partners never use condoms.

Multiple sexual partners and their psychosocial correlates: The population-based AIDS in Multiethnic Neighborhoods (AMEN) Study.

In this study we examined multiple partners in a household probability sample of heterosexuals. Thirty-seven percent reported 2 or more partners in the past year, and 6% reported 5 or more partners. Significant interactions among gender, ethnicity, and relationship status revealed complex relations. African American men without a primary partner were the most likely to have multiple partners; ethnic minority women with primary partners were the least likely. Psychosocial factors associated with multiple partners were examined with the AIDS Risk Reduction Model (ARRM). Situational factors influenced how ARRM variables related to multiple partners. Perceived risk, commitment to monogamy, and communication were all important correlates. Prevention efforts must focus on increasing awareness of the risks of heterosexual transmission of HIV for people in dating relationships and on strengthening sexual communication skills with new partners.

Supportive Friendships Moderate the Association between Stressful Life Events and Sexual Risk Taking among African American Adolescents

OBJECTIVE This study examined whether uncontrollable stressful life events were associated with sexual risk taking among adolescents across a 1-year period, and whether supportive friendships modified associations. DESIGN Participants were 159 sexually active African American adolescents (57% male; mean age [SD] = 17.0 [1.5] years at baseline). Participants were recruited for in-person interviews through random digit dialing in one inner-city neighborhood characterized by high rates of poverty and crime relative to the surrounding city. MAIN OUTCOME MEASURES Dependent variables included substance use before sexual activity and inconsistent condom use. RESULTS Among adolescents who reported low levels of supportive friendships, uncontrollable stressors were associated with greater levels of sexual risk taking over time. In contrast, uncontrollable stressors were not associated with sexual risk taking among adolescents who reported high social support from friends; risk taking was typically moderate to high among these adolescents. CONCLUSION Different processes may explain sexual risk taking among adolescents with varying levels of social support from friends. Adolescents with low support may be prone to engagement in health risk behavior as a stress response, while adolescents with high support may engage in risk behavior primarily due to peer socialization of risk.

IV. Multiple Sexual Partners Among Young Adults in High-Risk Cities:

Among a sample of 1,334 urban heterosexuals aged 18-25 from the 1990-1991 National AIDS Behavioral Surveys, 24% report having had more than one sexual partner during the past year. Young men are more than twice as likely as young women, and unmarried respondents are eight times as likely as married respondents, to have multiple partners. A multiple regression analysis of the interaction between race or ethnicity and education indicates that among whites, young people with 12 or more years of education are four times as likely to have multiple partners as are those with less than a high school education; among Hispanics and blacks, educational level is not related to having more than one partner. Among those with multiple partners, approximately 40% never use condoms with primary or secondary partners, and condom use decreases with increasing number of partners.

The HIV epidemic among older men who have sex with men.

Summary: The authors present HIV prevalence and risk behavior data for urban men who have sex with men (MSM) aged 50 years or older. Data are based on a probability sample of MSM conducted in 1997 (n = 2881 total; 507 older MSM) in New York, Los Angeles, Chicago, and San Francisco. The authors determined HIV status through self‐report and biologic measures. Risk behavior was assessed through self‐report. The authors found that HIV prevalence was 19% (95% CI: 14, 25) for men in their 50s and 3% (95% CI: 1, 10) for men in their 60s. No men in their 70s were HIV‐positive. Prevalence was at high levels for older blacks (30%), MSM who are injection drug users (21%), moderately heavy drug users (35%), and less closeted men (21%). Highrisk sex between serodiscordant partners was relatively constant (4%‐5%) across age groups older than 30 years of age and decreased among MSM in their 70s. Current levels of HIV among older urban MSM in the United States are very high, particularly among those in their 50s. High mortality rates among MSM with AIDS up to 1996 (before highly active antiretroviral therapy [HAART]) would account for the lower levels among men in their 60s and 70s. Because of HAART, we would expect HIV levels to increase in these age groups. Given high levels of risk behavior among MSM through the sixth decade of life, the authors would expect an older MSM epidemic of substantially larger proportion than that observed in the 1980s and 1990s.

III. Multiple Sexual Partners among Blacks in High-Risk Cities:

The National AIDS Behavioral Surveys collected data between June 1990 and February 1991 on the prevalence of multiple sex partners and condom use among 2, 166 blacks living in cities with a high prevalence of AIDS cases. Almost one-fifth (19%) of respondents report having had two or more partners in the year preceding the survey. More men (30%) than women (10%), and more single (25%) than married or cohabiting adults (8%), report that they have had multiple sexual partners in the previous year. Although respondents are more likely to use condoms with secondary than main sexual partners, substantial proportions of blacks with multiple sex partners used no condoms in the previous year with either their main (47%) or their secondary partners (35%).

Changes in condom use among heterosexuals in wave 3 of the AMEN Survey

We examined risk factors for HIV and changes in condom use among heterosexual adults (N = 987) over three waves of data from the AIDS in Multi‐Ethnic Neighborhoods (AMEN) cohort survey (1988–89, 1989–90, 1991–92). We found that respondents had maintained increases in condom use reported at Wave 2, but the overall picture is one of condom use having plateaued (and possibly decreased; see sales data). The self‐report condom use data parallel national data on condom sales for 1990 to 1992. Changes in condom use between Waves 2 and 3 were unrelated to social class, race / ethnicity, and age. Men and people without primary sexual partners were the most likely to report gains in condom use from Wave 2 to 3. At‐risk people did not show changes in condom use with primary sexual partners. People with multiple sexual partners at Waves 2 and 3 also did not change in condom use. However, people who acquired risk by Wave 3 showed significant increases in occasional condom use. The results call for renewed efforts to f...

Project ÒRÉ: A Friendship-Based Intervention to Prevent HIV/STI in Urban African American Adolescent Females:

There is an urgent need for continued innovation in the design of HIV/STI prevention interventions for African American females, a group at high risk for STIs and HIV. In particular, attention to social development and to culture is needed. The present study reports on a group randomized controlled trial of a friendship-based HIV/STI prevention intervention delivered at community-based centers in four San Francisco neighborhoods (n = 2, experimental; n = 2, control). This brief program focuses on youth and their friendship group (N = 264). Program outcomes vary by age at 3-month follow-up, evidencing decreases in risky sex in the oldest group (p ≤ .05), decreases in multiple partners in the middle age group (p ≤ .05), and increases in HIV testing in the youngest group (p = .05). Findings extend recent work on the efficacy of interventions to reduce sexual risk for racial and ethnic minority youth.

Survey of U.S. Human Research Protection Organizations: Workload and Membership

In a national survey of institutions with federally assured human research protection programs, we obtained workload and other relevant data on their Institutional Review Boards (IRBs) and management organizations. The number of IRBs increased substantially from 1995 to 2005/06 (491 to 2,728 IRBs) with a further increase in 2008 to 3,853 IRBs. Nationally, IRBs reviewed over a quarter million research applications in the year prior to our survey, of which 35% were new applications requiring full committee review. Compared to estimates from 1995, current IRBs review more new and full committee review applications, but the relative percentage of new and full committee applications remained about the same. High volume research institutions have IRBs with a substantially larger per person workload, relative to smaller volume IRBs (i.e., members spent nearly seven times more hours reviewing new applications outside formal committee meetings). Virtually all IRBs included community representatives as members (92%); however, a small number may not be compliant with federal regulations. The present findings suggest the need for research to (a) examine workload and its effects on review quality, research costs, and faculty morale, (b) develop methods for determining optimal fit between IRB workload demands and institutional labor and financing requirements, (c) construct benchmarks for judging reasonable workload for individual IRB members, and (d) examine if the need to recruit IRB scientific expertise from outside the institution, particularly true for smaller research institutions, causes delays in IRB review, and if a more effective way of locating and recruiting experts would improve quality and time to completion.