M. Mazur

SAT0452 Direct and Indirect Costs of Osteoarthritis the Republic of Moldova

Background Osteoarthritis (OA) is associated with healthcare resource utilization and loss or worker productivity. The total direct and indirect costs of OA can differ substantially across systems. No data as yet are available on economic impact of OA in Republic of Moldova. Objectives To estimate the direct and indirect costs of knee osteoarthritis in Republic of Moldova. Methods A cross-sectional study was performed from January 2012 to January 2013. There were included 256 patients that fulfilled the ACR classification criteria for knee OA (1991). The direct medical costs comprised: medication, hospitalization, medical visits and investigations; the direct non-healthcare costs included informal care and patient out-of-pocket payments. Human capital approach was used to estimate indirect costs by multiplying: 1) days of absence from work because of OA, with average earnings per capita per day for working patients; or 2) productivity loss with the market price of housekeeping for retirees/homemakers. Mean annual per patient costs were calculated from an employers perspective. Correlations were also calculated between the costs and quality of life (QoL) that was assessed by KOOS- Knee injury and Osteoarthritis Outcome Score (100% high QoL). Results There were 256 patients integrated in the study including 196 females and 60 males, mean age (SD) 62.4 (9.5) years (range 37 to 85 years). The disease duration (SD) was 8.1 (6.7) years (range 1-51).The KOOS results showed that the QoL constituted 35.7%, qualified as low. The average total cost excluding joint replacement, accounted

AB0789 How does the duration of the disease influence the quality of life

685, and the direct costs represented 71.04% (mean

AB0664 Level of satisfaction in patients with idiopathic inflammatory myopathies

485) per person per year and indirect costs - 29% (

AB0521 Quality of Life in Patients with Sle and Cutaneous Involvement

190), respectively. The direct costs represented 18.4% of annual incomes, the insurance cover just 50.7% from direct costs. The three major components of direct costs were hospitalization (48.3%), drug cost (26.4%) and informal care (13%). We established moderate correlation between direct costs and QoL (r=0.4, p<0.05), therefore the indirect costs were strongly correlated with quality of life level (r=0.7, p<0.05). Conclusions The direct costs of osteoarthritis in the Republic of Moldova population are high being comparable to those reported in European countries and the economic burden is important by relatively high out-of-pocket expenditures. The indirect costs are not a major component of the cost of illness; this is mainly due to the low monetary value of paid work. Both types of costs correlated with the quality of life. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.2527

SAT0312 Work Disability in Patients with Systemic Lupus Erythematosus in Moldavian Lupus Study Group

Background It is noticed that over the last decades the prognostic in patients with Idiopathic Inflammatory Myopathies (IIM) – a group of autoimmune disease characterised by muscle involvement, has improved along with increasement of disease duration and thus affects the quality of life. Objectives To assess the patient’s quality of life related to the duration of the disease. Methods We performed a cross-sectional study from December 2015 to December 2017, the patients included fulfilled the Bohan and Peter1 criteria for IIM. Demographic and clinical data were collected using a special questionnaire. Consistent with the objective the study group was divided in two subgroups by disease duration 1-less than 24 months and second subgroup maore than 2 years. In order to estimate the quality of life (QoL) was applied Short Form-8 with 8 items for 8 domains and two components: mental and physical. Statistical data was analysed using MedCalc software version 12. Results There were 67 patients enrolled in the study, including 51 females and 16 males with a F:M ratio of 3.2:1, mean age 53.1±12.5 (range 25–78). The disease mean disease duration was 8.3±5.3 (range 0.5–12) years, there were 16 patients in the subgroup with the disease duration less than 2 years. The mean physical component was 36.48±9.05 and the mental component – 41.69±9.62 points, determined as reduced quality of life. Regarding the QoL of patients from subgroup 1, we found the physical component – 38.15±8.83 and the mental was 40.95±9.22 points. In the second subgroup we appreciated the physical and the mental component – 35.77±9.14 and 42.01±9.86 points, respectively. It was identified moderate correlation (r=0.49 p<0.005) between the both domains of the QoL and disease duration till 2 years, for the duration of more than 2 years we found moderate correlation (r=0.51 p<0.005) with mental compound and a weak one for physical domain (r=0.24 p<0.005). Conclusions Patients with idiopathic inflammatory myopathies had reduced quality of life by both domains. Disease duration in patients with early idiopathic inflammatory myopathies – less than 2 years, has a greater impact on patient’s quality of life. Reference [1] Bohan A, Peter JB. N Engl J Med1975Feb 13;292(7):344–7. Disclosure of Interest None declared

AB1187 Role of Intangible Costs in the Economic Burden of Systemic Lupus Erythematosus

Background Idiopathic Inflammatory Myopathies (IIM) are the group of rare diseases that carry a significant impact on patients quality of life, influenced by the level of patients satisfaction regarding medical services. Objectives To assess the patients satisfaction and quality of life. Methods A cross-sectional study was performed from December 2015 to December 2016. There were included consecutive patients that fulfilled the Bohan and Peter1 criteria for IIM. The collected information was about demographic data, clinical and laboratory findings. The patients satisfaction was assessed by self-administered Patient Satisfaction Questionnaire (PSQ III)2, which is a 50-item tool, covering 7 domains: general satisfaction, technical quality, interpersonal aspects, communication, financial aspects, time spent with doctor, access/availability/convenience. To estimate the quality of life we applied Short Form-8 questionnaire with 8 items for 8 domains and two components: mental and physical. Results There were 32 patients enrolled in the study, including 23 females and 9 males, mean age 52.5±14.26 (range 25–78), the disease duration was 8.3±5.3 (range 0.5–12) years. The physical component was lower 37.49±8.49, than the mental component 44.96±6.24 points, we determined that the quality of patients life was reduced. The PSQ III results were: general satisfaction 20±2.93, technical quality 36.8±5.93, interpersonal aspects 26.50±4.92, communication 19.7±3.25 and access/availability/convenience indicated 44.75±6.29 score. The time spent with doctor was 7±1.15, a border score. The average result in the financial aspects domain was 21.6±6.6, lower than the midpoint scoring (24). We identified correlation between the quality of life and the access/availability/convenience PSQ III domain. For the mental compound the correlation was moderate (r=0.5 p<0.005) and for physical domain it was weak (r=0.27 p<0.005), these results can be explained by the fact that patients got accustomed with the disease, but they are more interested in access to care and require increasement of the duration of medical consultation. Conclusions Patients with idiopathic inflammatory myopathies have reduced quality of life; however they are satisfied of the medical attendance. The dissatisfaction was with the financial aspect, due to the long-term disease course and high indirect costs. References Bohan A, Peter JB. N Engl J Med 1975 Feb 13;292(7):344–7. Ware J.Jr. et al. Defining and measuring patient satisfaction with medical care. Eval Program Plann. 1983; 6(3–4): 247–63. Disclosure of Interest None declared

THU0492 Total Costs and Their Predictor Factors in Patients with Knee Osteoarthritis

Objectives To establish the relationship between cutaneous involvement and Quality of Life (QoL) in patients with systemic lupus erythematosus Methods Cross-sectional study of SLE patients with cutaneous involvement, fulfilling SLICC/ACR 2012 classification criteria. Cutaneous involvement was assessed by Cutaneous Lupus Erithematosus Disease Area and Severity Index (CLASI), disease activity – by SLEDAI and SLAM and QoL by SF-8 questionnaire. The Pearson correlation coefficient was calculated between the variables. Results The study included 92 Caucasian SLE female patients with a mean age of 40,0±12,6 yrs and a mean disease duration of 5,1±5,8 yrs. The mean age at the disease onset was 33,5±11,4 yrs and the mean SLICC/ACR criteria number – 6,1±2,8 points. The disease activity by SLEDAI and SLAM was appreciated as high with 1,24±10,4 and 12,1±8,6 points, respectively. The SLICC/ACR DI constituted 1,47±1,6 points. The cutaneous involvment by CLASI showed a mean activity of 4,7 points and a damage of 3,0 points, mean CLASI score being appreciated with 7,2 points. The QoL by SF-8 demonstrated low indices, compared to general population, in both domains: Physical Component Summary (PCS) and Mental Component Summary (MCS) with a mean value of 37,74 and 38,72 points, respectively. The analysis of Pearson coefficient between the QoL and CLASI did not show significant correlation (r≤0,2, p>0,05). The PCS og the QoL correlated inversely with the disease activity (r=-0,58 for SLAM and r=-0,45 for SLEDAI, p<0,05) and the MCS correlated inversely with SLICC/ACR classificatino criteria (r=-0,45, p<0,05). CLASI activity index correlated with SLAM and SLEDAI (r=0,45 for SLAM and r=0,37 for SLEDAI). Conclusions The QoL is dicreased in SLE patients by both components: physical and mental. The severity of cutaneous involvment did not correlate with the QoLs indices. Meantime, CLASI activity score correlated with disease activity and the MCP pf the QoL correlated with the number of SCLICC/ACR 2012 classification criteria. Disclosure of Interest None declared

SAT0353 The Relationship Between Patient Satisfaction with Medical Care and Disease Activity in Patients with Systemic Lupus Erythematosus in Republic of Moldova

Background As systemic lupus erythematosus (SLE) is a chronic disease, it can lead in time to important functional limitations that impair not only their quality of life but also their ability to work. Prior studies on work disability in patients with SLE have shown that about one third of the patients become disabled within 3–12 years of diagnosis 1,2. Objectives To assess the work disability in patients with systemic lupus erythematosus in Moldavian lupus study group. Methods Using a cross-sectional design, patients who fulfilled the SLICC (2012) classification criteria for SLE, were recruited from rheumatology departement. Data collection included demographics, disease duration, physician-rated indices of disease activity (SLAM) and damage index (SLICC DI). Work disability was defined by patients self-report. Results The study included 106 patients (97 females, 9 males) with a mean age (±SD) of 41,1±12,6 years, mean disease duration of 90,0±87,2 months. The disease activity by SLAM was 11±5,17 points and mean SLICC/ACR DI 1,9±2,4 points. The rate of self-reported work disability among the 106 patients studied was 35,8% (38 patients). Disability rate in the first year of disease was reported by 39,5% (15) patients; after 2 to 5 years of disease the estimated rate was of 47,4% (18 patients); after 6 to 10 years of disease the estimated rate was of 10,5% (4 patients) and after 10 years of disease the self-reported work disability was 2,6% (1 patient). Conclusions The rate of work disability was 35,8% with the highest rate in the first five years of disease, affecting younger persons, which make crucial to identify strategies aimed to reduce work disability is in those patients. References Yelin E, Trupin L, Katz P, Criswell L, Rush S. Prospective study of work dynamics in SLE. Lupus 2005; 14:218. Khanna S, Pal H, Pandey RM, Handa R. The relationship between disease activity and quality of life in systemic lupus erythematosus. Rheumatology 2004; 43:1536–40. Disclosure of Interest None declared

AB0604 Association of knee symptoms with self-reported physical function in knee osteoarthritis patients

Background Systemic lupus erythematosus (SLE) is a chronic, disabling, progressive disease, with many associated comorbidities, affecting patients during prime working years resulting in a high economic burden on society, producing high direct, indirect and intangible costs [1]. Pain and sufferings of patients because of a disease, which are usually measured by using the reduction in Quality of Life (QoL), define intangible costs. To date, there is no data available about intangible costs of SLE in the Republic of Moldova. Objectives To estimate the intangible costs of SLE in the Republic of Moldova. Methods We conducted a cross-sectional study including consecutive patients fulfilling the SLICC, 2012 classification criteria for SLE. The disease activity was calculated by SLAM and damage index - SLICC/ACR DI. The intangible costs were calculated using two methods: willingness-to-pay (WTP) for a hypothetical cure of SLE and QoL, estimated by SF-8 questionnaire. Results The study included 106 patients, female:male ratio 10,7:1, mean age ± SD of41,1±12,6 yr, mean disease duration ± SD 90,0±87,2 months. The disease activity by SLAM was 11±5,2 points and mean SLICC/ACRDI 1,9±2,4 points. The analysis of the mental and physical component status of the QoL showed a reduction of both variables compared to general population: PCS and MCS were 43,2±9,6 and 46,9±13,4 points, respectively. It was established a close significant negative correlation between physical component status and disease activity by SLAM (r=-0,83, p<0,001) and no correlation with variables as disease duration, age at onset, socio-economic status. The monetary value of intangible costs was characterized by a large distribution, ranging from 790 to 52,600 thousands Euros, with a mean value of 9,420 Euros. The monetary value of intangible costs was influenced by the disease activity and working status (p<0,05). Conclusions The intangible costs are an important component of SLEs total costs, influencing substantially the diseases economic burden in Republic of Moldova. References Turchetti G et al. Systemic lupus erythematosus and the economic perspective: a systematic literature review and points to consider. Clin Exp Rheumatol. 2012 Jul-Aug;30 (4 Suppl 73):S116-22. Epub 2012 Oct 16. Disclosure of Interest None declared

SAT0296 Relationship between disease activity index scores and subjective assessments in early systemic lupus erythematosus

Background Osteoarthritis (OA), as a common joints disease, is associated with high healthcare resource utilization. It is important to determine the economic burden of the disease and the possible predictors which may increase the cost of the disease. Objectives To estimate the total annual costs and their predictors in patients with knee osteoarthritis in our country. Methods A cross-sectional study was performed from January 2012 to January 2013. There were included consecutive patients that fulfilled the ACR classification criteria for knee OA (1991). We collected data on demographic and socioeconomic characteristics, function limitation, use of health and social services, and effect on occupation and living arrangements over the previous 12 months. The direct medical costs comprised: medication, hospitalization, medical visits and investigations; the direct non-healthcare costs included informal care and patient out-of-pocket payments. Human capital approach was used to estimate indirect costs. Mean annual per patient total costs were calculated from a patients perspective. The intangibles costs were assessed by Willingness to Pay method. The costs predictors were determined by multiple regression analyses using direct, indirect and total costs as outcome variables. This study was conducted according to the principles of the Declaration of Helsinki (1996) and good clinical practice. Results There were 256 patients integrated in the study including 196 females and 60 males, mean age 62.4±9.5 (range 37 to 85) years. The disease duration was 8.1±6.7 (range 1-51) years. The average total cost, accounted