M. Mostofa

Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, extract shows hypoglycemic effect and eases oxidative stress in alloxan-induced diabetic rats

The hydroethanolic extract of the flowering tops of Anthocephalus cadamba (Roxb.) Miq., Rubiaceae, a Bangladeshi medicinal plant, was studied for its potential hypoglycemic effect and antioxidant property in alloxan-induced diabetic rats. The extract induced significant reduction in serum glucose, and transaminases, e.g. aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatases (ALP), activities. Significant changes in the thiobarbituric acid reactive substances (TBARS), peroxidase and catalase levels during the experimental period were also observed. The results established that the hydroethanolic extract of the flowering tops of A. cadamba possesses hypoglycemic property and is able to protect liver and brain from oxidative damages caused by diabetes.

Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with aqueous extracts of Momordica charantia (karela) fruits

Abstract Objective To investigate the effect of aqueous extract of Momordica charantia (karela) (M. charantia) fruits on blood glucose level, pancreatic weight changes and histopathology of pancreatic changes in the streptozotocin (STZ) induced diabetic rats. Methods Thirty-six albino rats were used in the experiment; diabetes mellitus was induced in 30 adult albino rats, using intraperitoneal injection of 55 mg/kg STZ. Six non diabetic rats remained as control (T1). The diabetic rats were randomly assigned into five equal groups: diabetic control (T2) without any treatment, groups T3, T4, T5 and T6 were treated with aqueous extract of karela fruits daily at a doses of 250, 500 and 750 mg/kg and glibenclamide (5 mg/kg) up to 90 d, respectively. At Day 90, all rats were sacrificed, the pancreases of the rats were excised and processed. Results The results of this study indicate that aqueous extract of M. charantia fruits was able to reduce blood glucose level significantly compared with the diabetic control group (P Conclusions The present study suggests that oral feeding of M. charantia fruit juice has a significant anti-hyperglycemic effect and may have a role in the regeneration of the β cells in STZ diabetic rats.

Effect of tulsi (Ocium sanctum) leaves extract as a growth promoter in broiler productio

This study was conducted to determine the efficacy of tulsi ( Ocimum sanctum ) leaves extract as a growth promoter in broilers from January to June 2013 under Dept. of Pharmacology, Bangladesh agricultural University, Mymensingh-2022, Bangladesh. Fourty number of day old broiler chicks were taken and after seven days divided into two groups A and B. The B group was supplemented with tulsi leaves extract @ 1ml/litre in drinking water. Weekly observations were recorded for live body weight gain up to 5th weeks and blood test was performed at 17 th and 35 th days age of broiler to study hematological changes between control A and treatment B group. No significant difference in hematological changes was observed in both treatment and control group in 1st week of age but significant change in body weight gain was observed on 35 th day. They are 1500 g (control) and 1650 g (treated). The cost of production and economic study was carried out and it was observed that net profit in control group was 5.33 T.K/Kg broiler and in treatment group was 13.33 T.K/Kg broiler. Bacterial sensitivity test was positive in case of Escherichia coli and produced zone of inhibition 0.5 cm and other was negative. Asian J. Med. Biol. Res. June 2017, 3(2): 226-232