M. Murat Demet
Celal Bayar University
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Featured researches published by M. Murat Demet.
Medicinal Chemistry Research | 2010
Sule Gok; M. Murat Demet; Ahmet Özdemir; Gülhan Turan-Zitouni
Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2-thienyl)-5-aryl-2-pyrazolines that have previously been synthesized in our laboratory. Antidepressant-like activity was investigated in mouse forced swimming test (FST). Drug-induced effects on motor function were also tested by using digitized motor activity monitoring system. Shortened immobility time in FST was accepted as indicator of antidepressant-like activity. Results showed that three of eight pyrazoline compounds (1b, 1d, 1g) significantly shortened immobility time compared with control. Compound 1b was found to be more effective in FST than were clomipramine and tranylcypromine, used as reference antidepressant drugs. This compound also significantly increased horizontal motor activity, like clomipramine, compared with control mice. These results suggest that the N,N-disubstituted dithiocarbamate moiety of pyrazoline derivatives may have therapeutic antidepressant potential.
Respiratory Medicine | 2007
Hasan Yuksel; Ayhan Sogut; Ozge Yilmaz; M. Murat Demet; Dilek Ergin; Cengiz Kirmaz
Social Psychiatry and Psychiatric Epidemiology | 2007
Artuner Deveci; Oryal Taskin; Gönül Dinç; Hikmet Yilmaz; M. Murat Demet; Pinar Erbay-Dundar; Ender Kaya; Erol Özmen
Turkish journal of psychiatry | 2005
Artuner Deveci; Taşkin Eo; Erbay Dündar P; M. Murat Demet; Kaya E; Erol Özmen; Gönül Dinç
Anadolu Psikiyatri Dergisi | 2005
Artuner Deveci; M. Murat Demet; Bilgin Özmen; Erol Özmen; Zeliha Hekimsoy
Turk Psikiyatri Derg | 2005
Artuner Deveci; Taşkin Eo; Erbay D³ndar P; M. Murat Demet; Kaya E; Erol Özmen; Dinþ G
Turkish journal of psychiatry | 2002
M. Murat Demet; Taşkin Eo; Deniz F; Karaca N; Içelli I
Archive | 2006
Artuner Deveci; M. Murat Demet; Bilgin Özmen; Sabriye Özkay Kafesçiler; Erol Özmen; Zeliha Hekimsoy; Feyzullah Güçlü
Anadolu Psikiyatri Dergisi | 2005
M. Murat Demet; Artuner Deveci; Filiz Deniz; E. Oryal Taşkin; Emine Şimşek; Fatma Yurtsever
Archive | 2003
E. Oryal; Dilek Özmen; Erol Özmen; M. Murat Demet