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Featured researches published by M. Murat Demet.


Medicinal Chemistry Research | 2010

Evaluation of antidepressant-like effect of 2-pyrazoline derivatives

Sule Gok; M. Murat Demet; Ahmet Özdemir; Gülhan Turan-Zitouni

Many studies have shown that pyrazoline derivatives have therapeutic potential as antidepressant drugs. In this study, we aimed to investigate the antidepressant-like effect of eight new 1-[(N,N-disubstituted thiocarbamoylthio)acetyl]-3-(2-thienyl)-5-aryl-2-pyrazolines that have previously been synthesized in our laboratory. Antidepressant-like activity was investigated in mouse forced swimming test (FST). Drug-induced effects on motor function were also tested by using digitized motor activity monitoring system. Shortened immobility time in FST was accepted as indicator of antidepressant-like activity. Results showed that three of eight pyrazoline compounds (1b, 1d, 1g) significantly shortened immobility time compared with control. Compound 1b was found to be more effective in FST than were clomipramine and tranylcypromine, used as reference antidepressant drugs. This compound also significantly increased horizontal motor activity, like clomipramine, compared with control mice. These results suggest that the N,N-disubstituted dithiocarbamate moiety of pyrazoline derivatives may have therapeutic antidepressant potential.


Respiratory Medicine | 2007

Evaluation of sleep quality and anxiety–depression parameters in asthmatic children and their mothers

Hasan Yuksel; Ayhan Sogut; Ozge Yilmaz; M. Murat Demet; Dilek Ergin; Cengiz Kirmaz


Social Psychiatry and Psychiatric Epidemiology | 2007

Prevalence of pseudoneurologic conversion disorder in an urban community in Manisa, Turkey

Artuner Deveci; Oryal Taskin; Gönül Dinç; Hikmet Yilmaz; M. Murat Demet; Pinar Erbay-Dundar; Ender Kaya; Erol Özmen


Turkish journal of psychiatry | 2005

The prevalence of suicide ideation and suicide attempts in Manisa City Centre

Artuner Deveci; Taşkin Eo; Erbay Dündar P; M. Murat Demet; Kaya E; Erol Özmen; Gönül Dinç


Anadolu Psikiyatri Dergisi | 2005

Obez hastalarda psikopatoloji, aleksitimi ve benlik saygısı

Artuner Deveci; M. Murat Demet; Bilgin Özmen; Erol Özmen; Zeliha Hekimsoy


Turk Psikiyatri Derg | 2005

Manisa Ili Kent Merkezinde Intihar D³s³ncesi ve Girisimi Yayginligi.

Artuner Deveci; Taşkin Eo; Erbay D³ndar P; M. Murat Demet; Kaya E; Erol Özmen; Dinþ G


Turkish journal of psychiatry | 2002

[Depressive symptomatology among elderly residential home residents in Manisa: prevalence and related risk factors].

M. Murat Demet; Taşkin Eo; Deniz F; Karaca N; Içelli I


Archive | 2006

Obezitede Tedaviye Yanýt ve Aleksitimi

Artuner Deveci; M. Murat Demet; Bilgin Özmen; Sabriye Özkay Kafesçiler; Erol Özmen; Zeliha Hekimsoy; Feyzullah Güçlü


Anadolu Psikiyatri Dergisi | 2005

Obsesif-kompulsif bozuklukta sosyodemografik özellikler ve fenomenoloji

M. Murat Demet; Artuner Deveci; Filiz Deniz; E. Oryal Taşkin; Emine Şimşek; Fatma Yurtsever


Archive | 2003

Sal›k Yüksekokulu Ö¤rencilerinin fiizofreni ile ‹lgili Tutumlar›

E. Oryal; Dilek Özmen; Erol Özmen; M. Murat Demet

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Erol Özmen

Celal Bayar University

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Ayhan Sogut

Celal Bayar University

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Dilek Ergin

Celal Bayar University

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