M Nomura
Hokkaido University
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Publication
Featured researches published by M Nomura.
Transplantation | 2002
M Nomura; Kenichiro Yamashita; Masaaki Murakami; Megumi Takehara; Hayato Echizenya; Masao Sunahara; Norihiko Kitagawa; Miri Fujita; Hiroyuki Furukawa; T Uede; Satoru Todo
Background. Blockade of CD40-CD40 ligand (CD154) costimulatory pathway with anti-CD154 antibody (Ab) prolongs allograft survival in experimental organ transplantations; however, repeated agent administration is needed to provide an adequate immunosuppression. Seeking for simple and effective approach to interfere this signaling, we applied adenovirus-mediated gene therapy by encoding CD40Ig gene (AdCD40Ig). Methods. Liver graft from ACI (RT1av1) rat was transplanted orthotopically into LEW (RT1l) rat, and AdCD40Ig was given to animals via the penile vein immediately after grafting (n=6). Results. A single treatment with AdCD40Ig at 1×109 plaque forming units induced specific expression of CD40Ig gene on allograft liver, produced substantial amount of the protein in the sera, and allowed indefinite graft survival. Whereas, LEW recipients given no treatment or control adenovirus vector (AdLacZ) promptly rejected ACI liver. In addition, AdCD40Ig-treated, long-term survivors accepted skin graft from the donor strain but not the third party graft. Histopathology revealed that liver structure of the long-term surviving animals was completely preserved in normal with no infiltration of mononuclear cells. Conclusion. Blockade of CD40-CD154 pathway by CD40Ig gene therapy is a potent alloantigen-specific immunosuppressive strategy to induce permanent acceptance of liver allograft and would be a new therapeutic candidate in a clinical liver transplantation.
Transplantation Proceedings | 1999
Tomomi Suzuki; Tsuyoshi Shimamura; Maeng Bong Jin; R Yokota; Moto Fukai; J Iida; Masahiko Taniguchi; S Magata; H Horiuchi; Kenichiro Yamashita; M Nomura; T Omura; Akihiro Kishida; Hiroyuki Furukawa; Satoru Todo
Transplantation Proceedings | 2001
Naoyuki Yanagida; M Nomura; Kenichiro Yamashita; Megumi Takehara; Masaaki Murakami; Hayato Echizenya; Katsuhito Konishi; Norihiko Kitagawa; Hiroyuki Furukawa; T Uede; Satoru Todo
Transplantation Proceedings | 1999
Kenichiro Yamashita; M Nomura; T Omura; Megumi Takehara; Tomomi Suzuki; Tsuyoshi Shimamura; Akihiro Kishida; Hiroyuki Furukawa; Masaaki Murakami; Toshimitu Uede; Satoru Todo
Transplant International | 2004
Tomomi Suzuki; Maeng Bong Jin; Tsuyoshi Shimamura; Kenichiro Yamashita; Masahiko Taniguchi; M Nomura; R Yokota; Moto Fukai; Shinichiro Magata; Hiroyuki Horiuchi; Miri Fujita; Kazuro Nagashima; Hiroyuki Furukawa; Satoru Todo
Transplantation Proceedings | 1999
T Omura; Tomomi Suzuki; Tsuyoshi Shimamura; M Bon Jin; R Yokota; Moto Fukai; J Iida; Masahiko Taniguchi; S Magata; H Horiuchi; Kenichiro Yamashita; M Nomura; Akihiro Kishida; Michiaki Matsushita; Hiroyuki Furukawa; Satoru Todo
Transplantation Proceedings | 2001
Hayato Echizenya; Kenichiro Yamashita; Megumi Takehara; Katsuhito Konishi; M Nomura; Naoyuki Yanagida; Norihiko Kitagawa; T Kobayashi; Hiroyuki Furukawa; Manabu Inobe; T Uede; Satoru Todo
Transplantation Proceedings | 2001
M Nomura; Kenichiro Yamashita; Masaaki Murakami; Megumi Takehara; M Konishi; Hayato Echizenya; Naoyuki Yanagida; Masao Sunahara; Norihiko Kitagawa; Hiroyuki Furukawa; T Uede; Satoru Todo
Transplantation Proceedings | 1999
M Nomura; Kenichiro Yamashita; Megumi Takehara; T Omura; H Nakajima; Akihiro Kishida; Hiroyuki Furukawa; Satoru Todo
Transplantation | 2014
Catherine M. Robinson; Bruce M. Hall; Karren M. Plain; Giang T. Tran; Nirupama D. Verma; Rochelle Boyd; M Nomura; Suzanne J. Hodgkinson
