M.P. Konstantinou

Ipilimumab in Melanoma Patients with Brain Metastasis: A Retro­ spective Multicentre Evaluation of Thirty­eight Patients

Treatment with ipilimumab, a monoclonal antibody that antagonizes cytotoxic T-lymphocyte antigen-4 (CTLA-4), results in improved survival of patients with stage IIIc-IV melanoma. However, there is a lack of data on the efficacy of ipilimumab in patients with brain metastases. To evaluate the efficacy of ipilimumab for the treatment of brain metastasis in melanoma, a multicentre, retrospective analysis of 38 patients with brain metastases in melanoma, treated with ipilimumab in the context of the French Expanded Access Program, was performed. Three patients had a 3 partial response, 5 stable disease, 15 disease progression and 15 patients died during the induction phase due to disease progression. Median overall survival was 101 days (range 54-154). The brain metastases control rate was 16% (6/38). Ipilimumab may be effective in a few patients with central nervous system metastasis. However, patients with brain metastases and a low life expectancy may not benefit sufficiently from treatment with ipilimumab.

Active tuberculosis in psoriasis patients treated with TNF antagonists: a French nationwide retrospective study

There is limited information about active tuberculosis (TB) occurring in psoriasis patients treated with Tumor necrosis factor (TNF) antagonists.

Systemic allergic contact dermatitis caused by methyl aminolaevulinate in a patient with keratosis-ichthyosis-deafness syndrome: ALLERGIC DERMATITIS CAUSED BY METHYL AMINOLAEVULINATE

Aysha Al Malki1, Marie-Claude Marguery1, Françoise Giordano-Labadie1, Maria P. Konstantinou1, Lorraine Mokeddem1, Laurence Lamant2, Carle Paul1, Aude Maza1 and Juliette Mazereeuw-Hautier1 1Department of Dermatology, Paul Sabatier University and Toulouse University Hospital, 31400 Toulouse, France and 2Department of Anatomy and Cytopathlogy, Institut Universitaire du Cancer – IUCT Toulouse, 31059 Tolouse, France

Trichodysplasia spinulosa associated with Hiv infection: clinical response to acitretin and valganciclovir

M. Aleissa, M. P. Konstantinou, M. Samimi, L. Lamant, P. Gaboriaud, A. Touze, C. Ceppi, C. Bulai Livideanu and C. Paul Paul Sabatier University and Departments of Dermatology and Histopathology, University Hospitals of Toulouse, Toulouse, France; Unit e Mixte de Recherche 1282 Infectiologie et Sant e Publique and Department of Dermatology, Centre Hospitalier Universitaire Tours, Universit e Franc ois Rabelais, Tours, France; and Department of Internal Medicine, University Hospital of Nice, Nice, France

Focal facial hyperhidrosis associated with internal carotid artery dissection successfully treated with botulinum toxin A

Hyperhidrosis affects up to 3% of the population(1) . Secondary hyperhidrosis may be associated with infections, malignancies, endocrine or neurological diseases(2) . We report the first case of localized hyperhidrosis associated to Pourfour du Petit syndrome secondary to internal carotid artery dissection successfully and safely treated with botulinum toxin. This article is protected by copyright. All rights reserved.

Métastases cérébrales de mélanome traitées par ipilimumab : une indication à confirmer

C120 Métastases cérébrales de mélanome traitées par ipilimumab : une indication à confirmer M.-P. Konstantinou a,b,∗, S. Thellier a,b, T. Jouary c, C. Dutriaux c, C. Gaudy-Marqueste d, M.-A. Richard d, C. Bedane e, B. Guillot f, C. Paul a,b, N. Meyer a,b a Dermatologie, CHU de Toulouse, Toulouse, France b Université Paul-Sabatier, Toulouse, France c Dermatologie, CHU de Bordeaux, Bordeaux, France d Dermatologie, CHU de Marseille, Marseille, France e Dermatologie, CHU de Limoges, Limoges, France f Dermatologie, CHU de Montpellier, Montpellier, France ∗ Auteur correspondant.