M. S. Frasinyuk

Synthesis of Formononetin Analogs

Derivatives of the natural isoflavone formononetin were synthesized. Acylation and alkylation of the phenolic hydroxyls and the chromone ring were investigated.

Synthesis of analogs of natural isoflavonoids containing phloroglucinol

Analogs of the natural isoflavonoids biochanin A and orobol were synthesized. Alkylation involving phenolic hydroxyls and the chromone ring was studied.

Synthesis of cytisine derivatives of flavonoids. 2. Aminomethylation of 7-hydroxyisoflavones

Aminomethylation of natural 7-hydroxyisoflavones and their analogs by the alkaloid (−)cytisine was studied. Substituted 8-(cytisin-12-yl)methyl-7-hydroxyisoflavones were synthesized.

Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones

A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.

3-(2-Pyridyl)coumarins

Abstract3-(2-Pyridyl)coumarins were prepared by reaction of substituted salicylaldehydes and 2-pyridylacetonitrile. Benzylation, acylation, and aminomethylation of 7-hydroxy-3-(2-pyridyl)coumarin was studied.

Synthesis of amino-acid derivatives of formononetin and cladrin

Aminomethylation of natural isoflavones by amino acids was studied. Conditions for selective production of N-(4H-4-oxochromen-8-yl)methyl-substituted amino acids were found.

Chemistry of 3-hetarylcoumarins 3*. Synthesis and aminomethylation of 7′-hydroxy-3,4′- bicoumarins

An improved procedure for the synthesis of 7′-hydroxy-3,4′-bicoumarins has been developed. Their 8′-aminomethyl derivatives were obtained by interaction with aminals.

Synthesis of flavonoid derivatives of cytisine. 1. aminomethylation of 7-hydroxy-3-arylcoumarins

Aminomethylation involving the natural alkaloid (–)-cytisine of analogs of natural 3-arylbenzopyran-2ones was studied. Substituted 8-(cytisin-12-yl)methyl-3-aryl-7-hydroxycoumarins were synthesized.

Synthesis of 3′,4′-Dimethoxyisoflavone Derivaties

Abstract2-(Un)substituted-3′,4′-dimethoxy-7-hydroxyisoflavones were synthesized. Their derivatives substituted at the phenolic hydroxyl were prepared by alkylation and acylation. Aminomethyl derivatives were also prepared.

Synthesis of 4-aryl-3-[2-hydroxy-4-(2-cytisin-12-ylethoxy)phenyl]pyrazoles

Recyclization of N12-cytisinylethoxy derivatives of natural isoflavonoids and their analogs through the action of hydrazine hydrate was studied. A series of substituted 3-(2-hydroxyphenyl)-4-arylpyrazoles containing cytisine and pyrazole moieties were synthesized.