M. Venkat Reddy

Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol ☆

The total synthesis of (S,R,R,R)-Nebivolol, a hypertensive agent, is reported. Claisen rearrangement and a one-pot Sharpless asymmetric epoxidation, intramolecular epoxide opening with internal phenoxide anion to generate the chiral chromane are the key steps.

An Expedient Total Synthesis of cis-(+)-Sertraline from d-Phenylglycine

Abstract An efficient and practical total synthesis of cis -(+)-Sertraline is developed involving intramolecular Friedel–Crafts cyclization of an appropriately tailored d -phenylglycine.

Inexpensive Protocol for Reduction of Imines to Amines Using Polymethylhydrosiloxane (PMHS)

Abstract Amines have been prepared by reduction of imines using inexpensive Polymethylhydrosiloxane (PMHS) a 3 a hydride source activated by ZnCl2.

Addition of carbon nucleophiles to aldehyde tosylhydrazones of aromatic and heteroaromatic-compounds: total synthesis of piperine and its analogs

Addition of carbon nucleophiles to aldehyde tosylhydrazones of aromatic and heteroaromatic compounds is reported. New observations have been made wherein alkylative reduction is observed in some cases whereas alkylative fragmentation is noticed in others. These findings are exploited in the synthesis of the useful alkaloid piperine and its analogs.

Highly efficient synthesis of 3-alkyl/aryl-4-aryl-1,2,3,4-tetrahydroisoquinolines from N,N-dibenzylaminols

Abstract Substituted tetrahydroisoquinolines are synthesized in optically pure form using a Grignard reaction of N , N -dibenzyl aminol and Friedel–Crafts cyclization as the key steps.

Caveat in alkylative fragmentation of aldehyde tosylhydrazones of cyclic ethers

Abstract Tosylhtdrazones of aldehydes at the α-position of cyclic ethers when exposed to carbon nucleophiles produce either ring opened alkylated olefinic alcohols and/or cyclic alkylated vinyl ethers, the ratio of which is dependent on nature of hydrazone and nucleophile used.

New entry to alicyclic amines via alkylative fragmentation of cyclic aminoaldehyde tosylhydrazones

Tosylhydrazones of cyclic aminoaldehydes when exposed to aromatic and aliphatic Grignard reagents produce ring-opened acyclic unsaturated primary carbamates and carbamate alcohols in good yields.

One-Pot Conversion of Oximes to N-(tert-Butoxycarbonyl) Amines with Polymethylhydrosiloxane, Pd-C and Di-tert-butyl Dicarbonate

N-(tert-butoxycarbonyl) amines are directly obtained from oximes of aldehydes and ketones in one-pot when treated with polymethylhydrosiloxane (PMHS) and di-tert-butyl dicarbonate in the presence of catalytic amount of 10% Pd-C for the first time.

Zeolite H-ZSM 5 Catalysed Oxidation of Alcohols with Chromium Trioxide. Part 9.1 General Synthetic Methods†

A variety of alcohols are oxidised to the corresponding carbonyl compounds in excellent yields by chromium trioxide–H-ZSM 5 in dichloromethane at room temperature.