M. Yu. Kornilov

Reaction of 1,3-Dibromo- and 1,3-Dichloroacetone with 2-Aminoazaheterocycles

The reactions of 1,3-dibromoacetone with 2-aminoazines and 2-aminoazoles has been carried out for the first time and the pure intermediate quaternary salts have been isolated. They undergo cyclization to the corresponding imidazoazines and imidazoazoles containing a bromomethyl group. Similar condensations were carried out with 1,3-dichloroacetone.

Synthesis and reactions of heterocyclic azide derivatives. 6. Reactions of benzothiazole azides with 1,3-diketones and iotisch complexes

Cycloaddition of 5- and 6-azido-2-methylbenzothiazoles to magnesiumbromoacetylenes and 1,3-diketones leads to the formation of 2-methyl-5(6)-(1,2,3-triazol-1-yl)benzothiazoles. Reaction with benzoylacetone, for instance, results in the formation of two isomeric 4-acyl-1,2,3-triazoles, which differ in the position of the methyl and phenyl substituent radicals.

Isoindoles from phthalimidines. N-arylisoindoles

A convenient method was developed for the preparation of N-arylisoindoles by the reduction of the corresponding phthalimidines.

Chemistry of isoflavone heterocyclic analogs. 10. Synthesis of pyrimidines by recyclization of isoflavones and their heterocyclic analogs

Isoflavones and their thiazole and pyrazole analogs are recyclized into the corresponding 4-(2-hydroxyphenyl)-pyrimidine derivatives under the effect of amidines. Their PMR spectra were studied. The effects related to the formation and strength of the intramolecular hydrogen bond were examined.

3-AMINO-4-ARYL-1(2H)-ISOQUINOLONES

Abstract3-Amino-4-aryl-1(2H)-isoquinolones have been synthesized by treating 2-halobenzamides with arylacetonitriles. The angle of rotation of the 4-phenyl grop has been determined.

Mesoionic compounds with a bridged nitrogen atom. 8. Investigation of the structures of condensed thiazole derivatives by PMR spectroscopy

The structures of thiazolopyridinium, thiazoloquinolinium, and thiazolopyrimidinium oxides were studied by PMR spectroscopy with the aid of a lanthanide shift reagent [Eu(DPM)3].

Synthesis and reactions of some derivatives of 1,2-dihydrothiazolo [3,2-a]pyridinium salts

The condensation of 2-mercaptopyridine, 2-mercapto-4-methylpyridine, and 2-mercapto-6-methylpyridine with α-bromoacetaldehyde and its diethyl acetal has given cyclic products (3-hydroxy- and 3-ethoxy-2,3-thiazolo[3,2-a]pyridinium salts), from which cyanine dyes have been synthesized.

Length of Soliton Wave in the Excited State in the Cations of Symmetrical Pyridocyanines and Their Carbo and Hetero Analogs

Quantum-chemical calculations in the AM1 approximation were undertaken for the optimized geometry of the cations of polymethine dyes [R+—(CH=CH)n—CH=R], where R represents phenyl substituents or pyridinium, pyrylium, and thiopyrylium groups and n = 1-6, in the ground state and for the electron density distribution in the Frank – Condon excited state. It was found that excitation of the molecule by a light quantum leads to a decrease in the length of the charge wave (soliton). It was shown that the length of the soliton depends on the electron-donating character of the terminal groups R and on the length of the conjugated chain, while shortening of the soliton in the thiopyrylocyanines leads to disruption of its symmetry.

4-Hydroxyquinolones-2

Hydrazinolysis of 1-R-3-carbethoxy-4-hydroxyquinolones-2 was used to synthesize the corresponding hydrazides; thermal cyclodehydration of the latter yielded 3-oxopyrazolo-[4,3-c]-5-R-quinolones-4. Findings relating to their analgesic and antiphlogistic activity are outlined.

SYNTHESIS OF 3-AMINO-4-HETARYL-1(2H)-ISOQUINOLONES FROM CONDENSED ISOQUINOLONES WITH A BRIDGEHEAD NITROGEN ATOM

An alternative scheme for synthesis of 3-amino-4-hetaryl-1(2H)-isoquinolones is based on the reaction of condensed isoquinolones with a bridge nitrogen atom with amines.