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Dive into the research topics where Maciej Stodulski is active.

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Featured researches published by Maciej Stodulski.


Angewandte Chemie | 2009

Catalysts Based on Amino Acids for Asymmetric Reactions in Water

Joanna Paradowska; Maciej Stodulski; Jacek Mlynarski

Asymmetric organometallic and organocatalytic processes in aqueous systems are currently of great interest. A few years ago, only a few practitioners studied the subject; now organic reactions in water have become one of the most exciting research areas. The quest to identify water-compatible catalysts has evoked an intense search for new possibilities. Following natures lead, the application of amino acids as sources of chiral information seems particularly promising for aqueous systems. Herein we provide an overview of very recent advances in the area of asymmetric catalysis in water with amino acids and their derivatives as effective catalysts or essential components of catalysts.


Journal of Organic Chemistry | 2011

A Formal Synthesis of Ezetimibe via Cycloaddition/Rearrangement Cascade Reaction

Michał Michalak; Maciej Stodulski; Sebastian Stecko; Adam Mames; Irma Panfil; Magdalena Soluch; Bartłomiej Furman; Marek Chmielewski

A formal synthesis of a powerful cholesterol inhibitor, ezetymibe 1, is described. The crucial step of the synthesis is based on Cu(I)-mediated Kinugasa cycloaddition/rearrangement cascade reaction between terminal acetylene derived from acetonide of L-glyceraldehyde and suitable C,N-diarylnitrone. The adduct with (3R,4S) configuration at the azetidinone ring, obtained with high stereoselectivity, was subsequently subjected to deprotection of the diol side chain followed by glycolic cleavage and base-induced isomerization at the C3 carbon atom to afford the (3S,4S) aldehyde, which has been already transformed into ezetimibe by the Schering-Plough group.


Advanced Synthesis & Catalysis | 2007

Direct Catalytic Asymmetric Aldol Reactions Assisted by Zinc Complex in the Presence of Water

Joanna Paradowska; Maciej Stodulski; Jacek Mlynarski


Angewandte Chemie | 2009

Aminosäuren als Katalysatoren für asymmetrische Umsetzungen in Wasser

Joanna Paradowska; Maciej Stodulski; Jacek Mlynarski


Chemistry: A European Journal | 2006

Chiral Ytterbium Complex‐Catalyzed Direct Asymmetric Aldol‐Tishchenko Reaction: Synthesis of anti‐1,3‐Diols

Jacek Mlynarski; Bartosz Rakiel; Maciej Stodulski; Agata Suszczyńska; Jadwiga Frelek


European Journal of Organic Chemistry | 2008

Synthesis of Yb Complexes with Amino-Acid-Armed Ligands for Direct Asymmetric Tandem Aldol Reduction Reactions

Maciej Stodulski; Jaroslaw Jazwinski; Jacek Mlynarski


Tetrahedron | 2012

Synthesis of N,4-diaryl substituted β-lactams via Kinugasa cycloaddition/rearrangement reaction

Michał Michalak; Maciej Stodulski; Sebastian Stecko; Magdalena Woźnica; Olga Staszewska-Krajewska; Przemysław Kalicki; Bartłomiej Furman; Jadwiga Frelek; Marek Chmielewski


Tetrahedron-asymmetry | 2008

Synthesis of N-alkyl-N-methyl amino acids. Scope and limitations of base-induced N-alkylation of Cbz-amino acids

Maciej Stodulski; Jacek Mlynarski


Tetrahedron-asymmetry | 2011

Asymmetric aldol-Tishchenko reaction catalyzed by Yb-complexes with basic amino acid-derived ligands

Maciej Stodulski; Agnieszka Mamińska; Jacek Mlynarski


Tetrahedron Letters | 2016

Mild and efficient organocatalytic method for the synthesis of flavones

Filip Stanek; Maciej Stodulski

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Filip Stanek

Polish Academy of Sciences

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Joanna Paradowska

Polish Academy of Sciences

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Marek Chmielewski

Polish Academy of Sciences

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Michał Michalak

Polish Academy of Sciences

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Sebastian Stecko

Polish Academy of Sciences

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Jadwiga Frelek

Polish Academy of Sciences

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Adam Mames

Polish Academy of Sciences

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