Maciej Świątkowski

Treatment with double dose of omeprazole increases β-endorphin plasma level in patients with coronary artery disease

Introduction The proton pump inhibitor empirical trial, besides the analysis of symptoms, is the main method in the diagnosis of gastro-oesophageal reflux disease-related chest pain. β-Endorphin acts as an endogenous analgesia system. The aim of the study was verify whether β-endorphin plasma level is affected by omeprazole administration and influences the severity of anginal symptoms and outcome of the “omeprazole test” in patients with coronary artery disease (CAD) and chest pain of suspected non-cardiac origin. Material and methods Omeprazole was administered to 48 patients with CAD in a randomized, placebo-controlled, crossover study design. At the beginning of the study, and again after the 14-day omeprazole and placebo treatment, the β-endorphin plasma concentration was determined. Results The level of plasma β-endorphin after the administration of omeprazole was significantly greater than at the start of the study and following the placebo. Responders to omeprazole had an average lower β-endorphin plasma concentration than subjects who failed to respond to this therapy. Subjects with symptoms in class III (according to the Canadian Cardiovascular Society classification) after omeprazole administration had a greater β-endorphin plasma level than subjects in class II for anginal symptom severity. Conclusions Fourteen-day therapy with a double omeprazole dose significantly increases the β-endorphin plasma concentration in patients with CAD. Circulating β-endorphin does not seem to be involved in the mechanism for the “omeprazole test” outcome, although an individually different effect on pain threshold cannot be excluded.

Serrated polyps detected during screening colonoscopies

Aim of the study It is estimated that between 15% and 35% of sporadic colorectal cancers (CRC) developing from adenomas come from serrated polyps. Currently, the most effective method used to prevent CRC is the removal of adenomas, including serrated polyps, during colonoscopy. The aim of this paper is to analyze the changes characterized as serrated polyps and detected during screening colonoscopies performed as part of the Screening Program for Early Colorectal Cancer Detection (SPED). Material and methods In our center, as part of the nationwide SPED between 2000 and 2009, 1,442 screening colonoscopies were performed. Results Serrated polyps were found in 11.9% of all patients and in 45.8% of patients who had polyps removed by endoscopy. In screening colonoscopy of the large intestine, the following polyps were found most frequently: hyperplastic, < 1 cm, without a stalk, multiple, located in the distal part of the large intestine, in men and in patients with a first-degree relative with a history of abdominal cancer. Detecting and removing polyps was facilitated by the fact that the cecum was intubated and the bowel preparation had been performed either very well or well. The detection rate of serrated polyps was not influenced by patients’ place of residence or their age. Conclusions Serrated polyps constitute a frequent, and very frequent among removed polyps, abnormality detected during screening colonoscopy.

Evaluation of Nutrition and Eating Habits in Children and Adolescents Practicing Football in a Sports Club in Bydgoszcz, Poland

Proper diet is important for children and adolescents practicing sports, providing nutrients for the correct growth, optimal performance and recovery. Therefore, this study evaluated the diet and eating habits of children and adolescents practicing football. One hundred boys (aged 11~16) are involved in the study. Eating habits and consumption of 33 products were assessed using a modified KomPAN questionnaire. Subsequently, indices of healthy and unhealthy diet were determined. Only 30% respondents ate five meals per day and 16% kept fixed meal times. Almost 30% had a snack once daily, 90% ate fast food once a week, and 88% added sugar to beverages. One in ten ate sweets several times per week, while 20%—once daily. 86% ate fish once a week. 52% and 4% ate white and dark bread several times per day. Only 20% had buckwheat several times per week. White and red meat was eaten several times per week by 66.3% and 35.6%, while fish by only 5.7%. Only 20% had a moderate index of healthy diet and 90% had a low index of unhealthy diet. It is concluded that education of young footballers in nutrition is necessary to correct their eating habits and improve physical performance.