Magdy Y. Abdelaal

Enantioselective allylation of N-(trimethylsilyl)benzaldehyde imine using polymer-supported chiral allylboron reagents

Abstract Polymer-supported chiral N -sulfonylamino alcohols 3 and 4 obtained from copolymerization of enantiomerically pure amino alcohols 1c and 2c derived from (1 R )-(+)-camphor with styrene and divinylbenzene were treated with triallylborane, trimethallylborane, and tri(3,3-dimethylallyl)borane, respectively, to give polymeric allylating agents. N -(Trimethylsilyl)benzaldehyde imine was allowed to react with the polymeric chiral reagents to afford the corresponding primary homoallylamines in high yield and good enantioselectivities.

Chemical modification of chloromethylated polystyrene with pyridylazo‐β‐naphthol

Chloromethylated polystyrene was chemically modified through alkylation of pyridylazo-β-naphthol (PAN) in the presence of a phase-transfer catalyst. The chemical modification was achieved through O-alkylation as well as N-alkylation of PAN, leading to formation of polymer-supported quaternary ammonium salt in the latter case. Both types of a polymer-supported PAN moiety were detected by FTIR spectroscopic analysis. The complexation behavior of the polymer-supported PAN as an ion-exchanger toward some metal ions was studied. Thermogravimetric and differential thermogravimetric analyses data were used to study the kinetics of the thermal decomposition process of the ion-exchanger. Some thermodynamic parameters for the ion-exchanger were calculated by applying the rate theory of the first-order reaction.

Phase transfer catalyzed reactions of crosslinked chloromethylated polystyrene with vanillin

Abstract Chloromethylated polystyrene was reacted with vanillin under phase transfer catalyzed conditions. This reaction was performed under different conditions, including variations of the phase transfer catalysts, the reaction solvent, the type of base, the reaction time and temperature. In addition, the effect of the reaction technique (i.e., solid–liquid–liquid and solid–liquid–solid systems) on the reaction conversion was studied. Polymer-supported vanillin was evaluated for its utilization in polymer analogue conversions by performing condensation reactions of the aldehyde functionality with malononitrile, ethyl cyanoacetate, cyanoacetamide, cyanothioacetamide, 2-aminophenol, hydrazine hydrate and hydroxylamine hydrochloride. In all cases, the reactions were followed up by means of FTIR spectroscopic analysis.

Asymmetric reactions on polymers: diastereoselective allylation of polymer-supported chiral imines

Reaction of allylzinc reagent with enantiopure imine species attached to polystyrene proceeded smoothly with perfect diastereoselectivity and in excellent yield to afford polymer-supported chiral homoallylic amines.

Synthesis and characterization of some oligopolyalkylene‐polyamines

The reaction of diamines with dihalides in basic medium was carried out, leading to the formation of different varieties of both cyclic and acyclic products. In this work, the reaction was directed to form mainly one of them by reacting different diamines with both dichloroethane and dichloromethane as alkylating agents, using two techniques which were compared with each other. The obtained oligomeric products were characterized by using spectroscopic and elemental analyses.

Synthesis and characterization of polydi(3,4-dihydro-2H-pyran-2-methyl) adipate hydrogel

SummaryDi(3,4-dihydro-2H-pyran-2-methyl) adipate was synthesized and polymerized using different cationic initiators. The obtained polymers have been found to be both low molecular weight and water soluble. The polymeric samples were also characterized and their thermal stability was investigated. Such polymers can be considered as suitable matrices for controlled drug delivery by in-vivo biodegradation.

Synthesis and characterization of polyesters based on 3,4-dihydro-2H-pyran-2-yl-methanol

SummaryDiesters of 3,4-dihydro-2H-pyran-2-yl-methanol with oxalic and phthalic acid were prepared and polymerized. Boron trifluoride etherate, anhydrous ferric chloride, andp-toluene sulfonic acid have been selected as different cationic coinitiators. The resulting polymers can be considered as suitable matrices for controlled drug delivery byin vivo biodegradation. They were characterized and their thermal behaviour was investigated.ZusammenfassungDiester aus 3,4-Dihydro-2H-pyran-2-yl-methanol und Oxal- bzw. Phthalsäure wurden hergestellt und unter der Wirkung von Bortrifluorid-Etherat, wasserfreiem Eisentrichlorid undp-Toluolsulfonsäure als kationischen Koinitiatoren polymerisiert. Die erhaltenen Polymere können als geeignete Matrizen für kontrollierte Wirkstoffabgabe durchin-vivo-Bioabbau fungieren. Sie wurden charakterisiert und ihr thermisches Verhalten wurde untersucht.