Mahesh C. Goel

Pediatric Kidney: Functional Outcome After Extracorporeal Shock Wave Lithotripsy

PURPOSEnWe studied the efficacy, functional outcome and morphological changes following extracorporeal shock wave lithotripsy (ESWL*) of renal calculi in a pediatric population.nnnMATERIALS AND METHODSnWe prospectively evaluated 50 patients 2 to 12 years old (mean age 7.64) undergoing ESWL with the Siemens Lithostar Plus. Functional outcome was assessed by comparing total and ipsilateral glomerular filtration rates before and after ESWL. Glomerular filtration rate was measured using Gates method on a 99mtechnetium-pentetic acid radionuclide renal scan corrected to body surface area times 1.73 m.2. Ultrasound was performed to assess morphological changes after ESWL.nnnRESULTSnThe immediate fragmentation rate was 86% and the clearance rate was 82%. At the end of the study 40 patients were evaluable. Immediately after ESWL ultrasonography showed perirenal hematoma in 3 patients, intrarenal hematoma in 2 and subcapsular hematoma in 1. These changes resolved spontaneously at followup. There was no change in total or ipsilateral glomerular filtration rate at a mean followup of 31.7 months. Before and after ESWL total glomerular filtration rates were 86.58 +/- 12.43 and 86.27 +/- 12.82 ml. per minute per 1.73 m.2, respectively. Treated kidney glomerular filtration rate decreased insignificantly from 40.58 +/- 12.61 to 40.41 +/- 12.61 ml. per minute per 1.73 m.2 at 3 months. At the last followup the change in glomerular filtration rate was insignificant.nnnCONCLUSIONSnESWL is effective in the pediatric population, and it can be safely performed without long-term bio-effects on the function or morphology of the growing kidney.

Endoscopic Management of Traumatic Posterior Urethral Stricture: Early Results and Followup

PURPOSEnWe assessed the outcome of core through internal urethrotomy for traumatic posterior urethral stricture, and reviewed the followup results of these patients.nnnMATERIALS AND METHODSnDuring the last 4 years 13 patients with a stricture up to 2 cm. long underwent core through internal urethrotomy with C-arm fluoroscopy guidance and an orientation in 2 planes. Retrograde urethrotomy was performed and an 18F Foley catheter was left indwelling for 4 weeks, after which urethrotomy was repeated. All patients were advised to perform clean intermittent self-catheterization for urethral calibration and dilation. Outcome was defined as class 1-3 patients who required 2 or fewer urethrotomies with clean intermittent self-catheterization discontinued after the primary procedure, class 2-5 who required 2 or fewer urethrotomies with clean intermittent self-catheterization and class 3-5 who required 3 or more urethrotomies.nnnRESULTSnOf the 13 patients 8 (61%) did well after a mean followup of 17.7 months. The 3 patients with a class 1 outcome did well, while 2 of 5 with a class 2 outcome required repeat urethrotomy during followup. Of the 5 patients (39%) with a class 3 outcome in whom core through internal urethrotomy failed 3 required open surgery and 2 were lost to followup. Recurrence rate was 69% at 3 months and 25% at 12 months after the initial procedure. No patient was incontinent at last followup. Two patients had significant hematuria postoperatively, which resolved with conservative treatment.nnnCONCLUSIONSnEndoscopic treatment should be considered the first line procedure for all post-traumatic posterior urethral strictures. The morbidity of open surgery can be avoided in 61% of patients. Hospital stay, loss of work, morbidity and related complications are also markedly decreased with endoscopic therapy.

Chronic renal failure and nephrolithiasis in a solitary kidney: role of intervention.

PURPOSEnWe determined the role of intervention and its outcome in patients with a solitary kidney, nephrolithiasis and chronic renal insufficiency, as well as the role of clearance in these patients compared to those with a solitary kidney, nephrolithiasis and normal renal function.nnnMATERIALS AND METHODSnA total of 36 records was evaluable, including 16 from patients with normal (group 1) and 20 from those with abnormal (group 2) renal function. Group 2 was further subdivided into those with mild to moderate (group 2A) and advanced (group 2B) renal failure. Patients with acute renal failure were excluded from the study. Glomerular filtration rate was calculated by the Cockcroft and Gault formula. The reciprocal of serum creatinine was used to determine outcome.nnnRESULTSnGroups 1 and 2 were comparable demographically except for serum creatinine, stone bulk and hospital stay. Of 36 patients 8 with normal renal function and 15 with chronic renal failure underwent percutaneous nephrolitholapaxy, 6 underwent extracorporeal shock wave lithotripsy and 7 underwent open surgery. Total clearance was achieved in 25 of 36 patients (72%). Glomerular filtration rate improved in 24 patients, remained stable in 8 and deteriorated in 4. However, 3 patients had less than 20% deterioration and 1 had significant deterioration in function after intervention. Improvement in glomerular filtration rate after intervention was significantly greater in cases of advanced renal failure. Patients with residual stones did worse than those without residual calculi. Mean hospital stay, deterioration in glomerular filtration rate and major morbidity rate were significantly greater in patients with residual calculi than in those with total clearance.nnnCONCLUSIONSnIntervention should be contemplated in patients with a solitary kidney, stone disease and renal failure as in any other patient with stone disease, with the aim being total clearance. Stone eradication delays deterioration, and decreases the requirement for dialysis and renal replacement.

Management of Staghorn Calculus: Analysis of Combination Therapy and Open Surgery

Objective: To assess the role of primary open surgery versus the recommended combination approach (percutaneous and lithotripsy) to treat staghorn calculi in a developing country. Patients and Methods: Available records (n = 91) of patients with staghorn managed during the last 4 years were retrieved. Patients were placed in two groups, open surgery and combination group, according to the primary procedure chosen by the patient. Demographic data in two groups was comparable in most of the respects except that renal failure patients were more in the combination group. Stone clearance, major residue, auxiliary procedures, morbidity, hospital stay and the cost were studied in the two groups for comparison. Results: Complete clearance could be obtained in 66 and 59% with open and combination method respectively. Major residue (>16 mm2) was present in 21% of open and 38% of the combination group. In patients with primary stone burden <900 mm2, the total clearance rates were 66 and 60% in open and combination group, respectively. Total clearance was not affected by caliceal dilatation, total stone burden, pelvic and caliceal bulk separately or their ratio, as arrived by logistic regression analysis. The incidence of haematuria in the combination group was marginally higher, probably due to more renal failure patients in this group. Hospital stay in the two groups was comparable (13.0 days in combination vs. 12.1 days for open). The cost of treatment with combination group was significantly higher. Conclusion: Open surgery for staghorn is still an economically viable option for difficult stone disease, specially in a developing country, with comparable efficacy, favourable morbidity and hospital stay.

Functional Bladder Neck Obstruction: A Rare Cause of Renal Failure

We studied 7 men and 6 women (average age 33 years) who presented in renal failure with obstructive voiding symptoms or retention. Of these patients 11 had a dilated upper tract and 2 had shrunken kidneys. Mean serum creatinine at presentation was 7.0 mg./dl. No abnormality was noted on cysto-panendoscopy, retrograde urethrography and voiding cystourethrography. The patients were initially treated with clean intermittent self-catheterization following 7 to 10 days of indwelling catheterization. The majority of patients had low pressure and low flow rate at initial presentation but high end filling pressure (mean 35.3 cm. water), high voiding pressure (mean 118.9 cm. water), high opening pressure (mean 95.3 cm. water) and low peak flow (mean 5.7 ml. per second) on video pressure flow electromyography. The external sphincter was relaxed during voiding but the bladder neck opened intermittently or inadequately. No proper funneling of the bladder neck was seen. Thus, functional bladder neck obstruction was considered to be responsible for obstructive voiding in these patients. Of the patients 3 void to completion with the help of alpha blockers alone, 5 underwent bladder neck incision and are voiding well, and 5 were practicing clean intermittent self-catheterization at last followup. Serum creatinine returned to near normal in 10 patients. End stage renal failure persisted in 2 patients, 1 of whom underwent renal transplantation and is voiding well but the other died without having undergone renal replacement therapy. In the remaining patient serum creatinine was stable at 3.2 mg./dl. Mean serum creatinine at 6 months of followup was 2.33 mg.%. Bladder neck obstruction is a rare cause of renal failure which can be corrected if treated appropriately.

Spontaneous perforation of the ureter : Endourological management with renal preservation

Spontaneous perforation of the ureter proximal to an obstruction has not been well described in the literature. We present a rare case of spontaneous perforation of the ureter, proximal to a radiolucent upper ureteric stone, in a 58-year-old diabetic female, causing a large infected urinoma and septicaemia in a solitary functioning kidney. The diagnosis was confirmed by computer tomography scan. We managed the case successfully by endourology only. The case emphasizes the importance of the differential diagnosis in a diabetic patient with obstructive uropathy.

Lingual Metastasis from Renal Cell Carcinoma Management and Review of the Literature

A case of anterior lingual swelling, which on excision biopsy was diagnosed as a secondary from renal cell carcinoma, is presented. We reviewed the indexed literature and present a review of the literature and current management of this uncommon problem.

Dynamic Rectus abdominis Tendon Colposuspension for Female Stress Urinary Incontinence: A New Procedure and Its Follow-Up

Aims and Objective: To describe the technique, results and follow-up of dynamic rectus abdominis tendon colposuspension (DRTC) in the management of female stress urinary incontinence (SUI). Patients and Methods: Eighteen patients with SUI were studied prospectively from 1998 to 1999 who underwent DRTC. Type I and type II SUI patients with or without mild to moderate cystocoele were included in the study. A complete preoperative work-up was done as described in detail in this article. Follow-up assessment was done at 6 weeks, 3 and 6 months and then annually involving a SEAPI quality-of-life score, a satisfaction questionnaire, urge symptoms and assessment of dryness. Results: Mean follow-up of these 18 patients was 20 ± 6 months. Cure of symptoms and dryness was achieved in 16/18 (89%) of the patients. Four of 9 patients had residual urge symptoms and 2 developed de novo urge, which settled by 3 months; no patient required long-term anticholinergics. Three patients required clean self-intermittent catheterization (CSIC) immediately postoperatively but only 1 patient continued to perform CSIC after 3 months. Mean operating time was 41 ± 10 min and mean hospital stay was 3.5 ± 1 days. There were two failures, one in a patient with a neurogenic bladder and one in a patient with multiple previous pelvic operations. One so-called failure uses <2 pads/day postoperatively with an improvement in both symptom and dryness score. Postoperative complications include blood transfusion in 1, urinary tract infection in 1 and wound infection in 1 patient. All the patients with initial good results showed persistent results over follow-up. Conclusions: DRTC is a simple procedure with minimal morbidity showing good results, which are consistent on follow-up.