Mahesh L. Patil

Enantioselective Wacker-type cyclization of 2-alkenyl-1,3-diketones promoted by Pd-SPRIX catalyst.

An enantioselective intramolecular Wacker-type cyclization of 2-alkenyl-1,3-diketones catalyzed by a Pd(II)-SPRIX complex was developed. The reaction proceeded in a 6-endo-trig mode to give the desired chromene derivatives with moderate to good enantioselectivity. Isomerization of C-C double bonds via a pi-allyl Pd intermediate was involved as the key step.

Recent developments on chiral ionic liquids: design, synthesis, and applications.

The recent progress in chiral ionic liquids with respect to their syntheses and applications in enantioselective reactions and chiral recognition is described. In addition to the conventional chiral ionic liquids derived from chiral natural products, a library of novel chiral spiro compounds, including spiro bis(pyridinium) and spiro bis(imidazolium) salt, is also described.

Total synthesis of (±)-brasiliquinone B

Abstract The total synthesis of (±)-brasiliquinone B has been achieved via a Friedel–Crafts alkylation approach. In contrast, a Friedel–Crafts acylation approach for the synthesis of (±)-brasiliquinone B resulted in formation of A ring aromatized tetracyclic products.

First total synthesis of (±)-brasiliquinone B

Abstract Brasiliquinone B (2) was synthesized from 7-methoxy-1-tetralone in 8 steps making use of Friedel-Crafts alkylation as a key step.

Spiro Crown Ethers Bearing (S)-1,1'-Spirobiindanes as Chiral Backbones

The synthesis of spiro chiral crown ethers ((S)-1a) and ((S)-1b) has been achieved. The combination of (S)-1a and KOH promoted the asymmetric alkylation of glycine derivative (2) with moderate enantioselectivity.

The synthesis of substituted tetrahydro-1H-xanthen-1-ones and xanthenes

A short and an efficient methodology for the synthesis of substituted tetrahydro-1H-1-xanthenones and xanthenes is described.

First total synthesis of the antitumor antibiotic (±)-resorthiomycin

Abstract The first total synthesis of (±)-resorthiomycin, an antitumor antibiotic has been achieved.