Mahmut Miski

DAUCANE ESTERS FROM FERULA RIGIDULA

In addition to several known daucane aryl esters 11 new daucane esters and a new phenyl propanoid ester were isolated from the roots of Ferula rigidula. The structures of the new esters were elucidated by spectral analyses.

Daucane esters from Ferula communis subsp. communis

Abstract Fourteen daucane esters together with a known propiophenone 3,4-methylenedioxy-5-hydroxy-propiophenone, were isolated from Ferula communis subsp. communis . Except for the 6-( p -anisic acid) ester of jaeschkeanadiol all these esters are new. Structures were elucidated using spectral properties of the esters and their partial hydrolysis products. X-ray diffraction analysis of one of the compounds confirmed its structure including the stereochemical assignments made on the basis of spectral data.

Cyclic farnesyl-coumarin and farnesyl-chromone derivatives from Ferula communis subsp. Communis

In addition to the known sesquiterpene-coumarin samarcandin and two known phenylpropanoids, two new cyclic farnesyl-coumarin and two new cyclic farnesyl-chromone derivatives were isolated from the benzene extract of the roots of Ferula communis subsp. communis. Structures of the new compounds were elucidated by spectral methods.

Fercolide, a type of sesquiterpene lactone from Ferula communis subsp. communis and the correct structure of vaginatin

Abstract Together with the known daucene ester 14- p -anisoyloxy-dauc-4,8-diene, a new ester, fercomin and the first known daucane-γ-lactone, fercolide, were isolated from Ferula communis subsp. communis . Structures for these compounds were elucidated on the basis of their spectral properties and the structure of fercomin was confirmed by X-ray analysis. A revised structure of vaginatin is discussed.

SESQUITERPENE ARYL ESTERS FROM FERULAGO ANTIOCHIA

Abstract In addition to the known phenylpropanoid myristicin, the petrol extract of the roots of Ferulago antiochia yielded six new germacrane esters and a new alloaromadendrane ester. The structures were elucidated by spectral and chemical methods.

Guaiane sesquiterpenes from Decachaeta scabrella

Abstract From the dichloromethane extract of leaves of Decachaeta scabrella , in addition to three known guaianolides and two flavonoids, a new guaianolide, 11α, 13-dihydroxerantholide, and two new guaiane acids, pechueloic acid and 11,13-dihydropechueloic acid, were characterized. The structures of the new compounds were determined by spectral and chemical methods.

Sesquiterpene lactones of Onopordon tauricum

Abstract The chloroform extract of the leaves of Onopordon tauricum yielded 10 sesquiterpene lactones, including a new elamanolide and four new eudesmanolides. The structures of the new compounds were elucidated by chemical transformations and modern spectral methods.

7α-Hydroxy-sesquiterpene lactones from Decachaeta ovatifolia

Abstract In addition to the known sesquiterpene lactone pinnatifidin, and the flavones 6-methoxyacacetin and 6-methoxyapigenin, the dichloromethane extract of the aerial parts of Decachaeta ovatifolia afforded four new sesquiterpene lactones: a germacranolide 7α-hydroxycostunolide, a guaianolide 4α,15-dihydro-7α-hydroxy-3-desoxyzaluzanin C and two eudesmanolides, 7α-hydroxysantamarine and 7α-hydroxyreynosin. The structure of 7α-hydroxycostunolide was confirmed by X-ray analysis.

Apiene esters from Ferula haussknechtii

Abstract Ten new apiene-type humulenoid esters were isolated from the root of Ferula haussknechtii . The structures were elucidated by spectroscopic methods.

Sesquiterpene lactones from Perityle vaseyi

Abstract The well-known germacrolide, eupatoriopicrin, and two additional sesquiterpene lactones, were isolated from Perityle vaseyi . The latter two lactones, one a novel guaianolide and the other a known germacrolide, both contain unusual ten carbon diester side chains attached at C-8. The chemical evidence, in conjunction with morphological data, suggest that Perityle, and hence the subtribe Peritylinae, should be placed in the tribe Heliantheae.