Mahmut Sami Metin

Coexistence of nevus flammeus and nevus depigmentosus: Is it a new subtype of phakomatosis pigmentovascularis?

Türkderm-Deri Hastalıkları ve Frengi Arşivi Dergisi, Galenos Yayınevi tarafından basılmıştır. Turkderm-Archives of the Turkish Dermatology and Venerology, published by Galenos Publishing. Phakomatosis pigmentovascularis is a rare genodermatosis characterized by combination of vascular malformations and pigmented nevi. There are numerous subtypes of phakomatosis pigmentovascularis and various classifications have been proposed in the literature. Nevus depigmentosus and dermatomal nevus flammeus were detected in a 7-month-old baby girl with birthmark on the face and body. Only one case was found to be present with similar clinical features in the literature. We have reported this case because we assume that it may be defined as a new type of phakomatosis pigmentovascularis. (Turkderm 2015; 49: 167-8)

A retrospective study of 102 patients with pemphigus

Türkderm-Deri Hastalıkları ve Frengi Arşivi Dergisi, Galenos Yayınevi tarafından basılmıştır. Turkderm-Archives of the Turkish Dermatology and Venerology, published by Galenos Publishing. Background and Design: Pemphigus is a severe and life-threatening chronic autoimmune mucocutaneous blistering disease. The aim of this study was to evaluate and analyze the course, prognostic factors and epidemiological, clinical and therapeutic features of pemphigus in patients followed between 2004 and 2013. Materials and Methods: We performed a 10-year retrospective study of patients diagnosed with pemphigus in Erzurum. The parameters that were evaluated include age, sex, diagnostic methods, duration of hospitalizations, distribution of lesions, duration of treatment and therapeutic doses. Results: The results showed that the estimated annual incidence rate was 1.31 cases per 100.000 person-years. The male to female ratio was 1: 0.81. The mean age at onset of the disease was 48 years (range: 7-95 years). Thirty-six patients had only skin lesions and sixty-six cases had both skin and oral mucosal lesions. The majority of the patients (58.8%) with pemphigus were treated with middle or high-dose corticosteroids (40-160 mg/day). Conclusions: Pemphigus vulgaris is the most common clinical subtype in Erzurum and the mean age of the disease onset in the present study was found to be a decade earlier than in other parts of the world. The patients with both oral mucosa and skin involvement required higher corticosteroid doses and longer hospitalization time when compared to the patients with oral mucosa involvement alone. (Turkderm 2015; 49: 125-8)

Bullous pemphigoid in Erzurum: A 10 year retrospective study

Atatürk Üniversitesi Tıp Fakültesi, Deri ve Zührevi Hastalıkları, ***Tıbbi Patoloji Anabilim Dalı, Erzurum, Türkiye *Afşin Devlet Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, Kahramanmaraş, Türkiye **Medeniyet Üniversitesi Tıp Fakültesi, Göztepe Eğitim ve Araştırma Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, İstanbul, Türkiye ****Kayseri Eğitim ve Araştırma Hastanesi, Deri ve Zührevi Hastalıkları Kliniği, Kayseri, Türkiye Okan Kızılyel, Ömer Faruk Elmas, Handan Bilen, Mahmut Sami Metin*, Necmettin Akdeniz**, Betül Gündoğdu***, Mustafa Atasoy****

Pyogenic granuloma-like Kaposi sar-coma: Report of two cases

SUMMARY Kaposi sarcoma is a vascular tumor associated with Human Herpes Virus-8 infections. Lesions predominantly present at mucocutaneous sites but may involve all organs. There are many kinds of Kaposi sarcoma variants. Pyogenic granuloma like Kaposi sarcoma is a new variant which protrudes from skin and resembles a pyogenic granuloma. We decided to report two cases of Kaposi sarcoma because there are only few case reports about pyogenic granuloma like Kaposi sarcoma in literature, which is usually misdiagnosed as pyogenic granuloma. Keywords: Human Herpes Virus-8, kaposi sarcoma, pyogenic granuloma OZET Kaposi sarkomu Human Herpes Virusu-8 enfeksiyonu ile iliskili vaskuler bir tumordur. Lezyonlar genellikle mukokutanoz bolgelere yerlesir. Ancak tum organlarda gorulebilir. Kaposi sarkomunun bircok varyanti vardir. Piyojenik granulom benzeri Kaposi sarkomu deriden kabarik olan ve piyojenik granuloma benzeyen yeni bir varyanttir. Literaturde, piyojenik granulom benzeri Kaposi sarkomu ile ilgili sadece birkac olgu sunuldugu ve genellikle piyojenik granulom yanlis tanisi aldigi icin Kaposi sarkomlu iki olguyu sunmaya karar verdik. Anahtar sozcukler: Human Herpes Virusu-8, kaposi sarkomu, piyojenik granulom

Osler-Weber-Rendu syndrome: A case report

Osler-Weber-Rendu (Hereditary Hemorrhagic Telangiectasia) is an autosomal dominant disease characterized by telangiectasia on mucosa and skin and arteriovenous malformations in visceral organs. Telangiectasia on lips, tongue, ear, nasal mucosa, palmoplantar region and nail beds are typical findings in the disease. Visceral arteriovenous malformations are common in patients who have visceral involvements. Our case was 34 years old woman presented with hemangioma on her right side of face and lips, telangiectasia on oral mucosa and arteriovenous malformation in her lower lobe of left lung. Diagnosis was Osler-Weber-Rendu disease. We decided to report this case because it is rarely seen and arteriovenous malformation was present in the lung of the patient.

Osler-Weber-Rendu sendromu: Bir olgu sunumu

Ozet Osler-Weber-Rendu sendromu [Herediter Hemorajik Telenjiektazi] deri ve mukozalarda telenjiektaziler ve ic organlarda arteriyovenoz malformasyonlar ile karakterize otozomal dominant gecis gosteren bir hastaliktir. Dudak, dil, damak, kulak, nazal mukoza, palmoplantar bolge ve tirnak yataklarinda yerlesim gosterebilen telenjiektaziler hastaligin tipik bulgusudur. Ic organ tutulumu olan hastalikta pulmoner arteriovenoz malformasyon siktir. Olgumuz dudaginda ve yuzun sag yarisinda hemanjiom, oral mukozada telenjiektaziler ve sol akciger alt lobunda arteriyovenoz malformasyonu olan 34 yasinda kadin hastaydi. Osler-Weber-Rendu sendromu tanisi konuldu. Hastaliginin nadir gorulmesi ve akcigerinde eslik eden arteriyovenoz malformasyonu bulunmasi nedeniyle olgumuzu sunmayi uygun gorduk. Anahtar sozcukler: Herediter hemorajik telenjiektazi, Osler-Weber-Rendu sendromu, pulmoner arteriyovenoz malformasyon Abstract Osler-Weber-Rendu (Hereditary Hemorrhagic Telangiectasia) is an autosomal dominant disease characterized by telangiectasia on mucosa and skin and arteriovenous malformations in visceral organs. Telangiectasia on lips, tongue, ear, nasal mucosa, palmoplantar region and nail beds are typical findings in the disease. Visceral arteriovenous malformations are common in patients who have visceral involvements. Our case was 34 years old woman presented with hemangioma on her right side of face and lips, telangiectasia on oral mucosa and arteriovenous malformation in her lower lobe of left lung. Diagnosis was Osler-Weber-Rendu disease. We decided to report this case because it is rarely seen and arteriovenous malformation was present in the lung of the patient. Keywords: Osler-Weber-Rendu syndrome, hereditary hemorrhagic Telangiectasia, pulmonary arteriovenous malformation

Erlotinib induced acneiform eruption: A case report

Erlotinib is an epidermal growth factor inhibitor. It is used for refractory, local invasion or metastasized non-small cell lung cancer. Erlotinib doesn’t cause severe systemic side effects like cytotoxic drugs. But it causes toxic side effects in skin. Acneiform eruption is the most common side effects related to erlotinib using. It is thought that balance is disturbed between differentiation and maturation of keratinocytes, ecrine and sebaceous gland cells and hair follicle cells in etiology. Topical metronidazole, clindamycin, topical salicylic acid and tetracycline can be used in treatment. In case of severe acneiform eruption dose of erlotinib may be reduced or treatment of erlotinib may be delayed. Our case was 67 years old male presented with acneiform eruption on his face after erlotinib treatment for non-small cell lung cancer. We decide to report this case because early diagnosis and treatment of skin lesions related to erlotinib treatment is important for patient compliance with erlotinib treatment.