Makonnen Asefa

Food insecurity, stressful life events and symptoms of anxiety and depression in east Africa: evidence from the Gilgel Gibe growth and development study

Objectives: Common mental disorders are a major contributor to the burden of disease in developing countries. An assessment was carried out of whether food insecurity and exposure to stressful life events, two common features of life in sub-Saharan Africa (SSA), are associated with symptoms of mental disorders among adults. Methods: The Gilgel Gibe Growth and Development Study (GGGDS) is an ongoing cohort study in rural Ethiopia. Participants of the GGGDS were randomly selected from households from a complete census of persons living in the area. The Hopkins Symptom Checklist and the Harvard Trauma Questionnaire were used to assess anxiety and depression and post-traumatic stress symptoms. Results: Among 902 adult participants, food insecurity, stressful life events and symptoms of common mental disorders were highly prevalent. In separate multivariate models adjusting for potential confounders, food insecurity and stressful life events were independently associated with high symptoms of depression, anxiety and post-traumatic stress. Conclusions: Potentially modifiable stressors may influence variation in common mental disorders in Ethiopia, and SSA more generally. These findings suggest that the negative effects of food insecurity extend beyond nutritional outcomes and that interventions that promote food security may also positively influence adult mental health in the region.

Women’s preferences for obstetric care in rural Ethiopia: a population-based discrete choice experiment in a region with low rates of facility delivery

Background Delivery attended by skilled professionals is essential to reducing maternal mortality. Although the facility delivery rate in Ethiopias rural areas is extremely low, little is known about which health system characteristics most influence womens preferences for delivery services. In this study, womens preferences for attributes of health facilities for delivery in rural Ethiopia were investigated. Methods A population-based discrete choice experiment (DCE) was fielded in Gilgel Gibe, in southwest Ethiopia, among women with a delivery in the past 5 years. Women were asked to select a hypothetical health facility for future delivery from two facilities on a picture card. A hierarchical Bayesian procedure was used to estimate utilities associated with facility attributes: distance, type of provider, provider attitude, drugs and medical equipment, transport and cost. Results 1006 women completed 8045 DCE choice tasks. Among them, 93.8% had delivered their last child at home. The attributes with the greatest influence on the overall utility of a health facility for delivery were availability of drugs and equipment (mean β=3.9, p<0.01), seeing a doctor versus a health extension worker (mean β=2.1, p<0.01) and a receptive provider attitude (mean β=1.4, p<0.01). Conclusion Women in rural southwest Ethiopia who have limited personal experience with facility delivery nonetheless value health facility attributes that indicate high technical quality: availability of drugs and equipment and physician providers. Well-designed policy experiments that measure the contribution of quality improvements to facility delivery rates in Ethiopia and other countries with low health service utilisation and high maternal mortality may inform national efforts to reduce maternal mortality.

Parental symptoms of common mental disorders and children's social, motor, and language development in sub-Saharan Africa

Background: There is increasing interest in the social determinants of childrens developmental outcomes in developing countries because of the links with schooling, behavioral, and employment outcomes. Yet, little is known about the impact of household and caretaker variables in influencing developmental outcomes in rural, developing country settings. Aim: The study examined the relative impact of individual and household variables and caretaker symptoms of common mental disorders on childrens personal–social, fine and gross motor, and language development. Subjects and methods: A total of 431 children aged 3–24 months in a rural Ethiopian setting were studied. Children underwent a developmental assessment and parents independently provided information on household characteristics and were administered anxiety and depression symptom inventories. Results: In adjusted multivariable models, maternal symptoms of mental disorders were associated with both global development and most developmental sub-scales (p < 0.01) except language developmental; there was no consistent relation between paternal symptoms of mental disorders and child development. Nutritional stunting was generally a risk factor for lower developmental scores but few household-level variables were associated with child development. Conclusion: Child development in this setting is strongly associated with child age and maternal depression. If these findings are replicated elsewhere, they may suggest that interventions aimed at improving maternal depression may have an important role to play in efforts to improve child development and to mitigate the intergenerational transmission of poor health in sub-Saharan Africa.

Malnutrition and mental development: is there a sensitive period? A nested case-control study.

To examine the possibility that there is an early sensitive period for the effects of malnutrition on cognitive development, three groups of children (N = 197) were recruited from a birth cohort with known growth characteristics in south-west Ethiopia (N = 1,563). All had initial weights > or = 2,500 g. Early growth falterers dropped in weight below the third centile (z < -1.88) of the NCHS/WHO reference population in the first 4 months. Late growth falterers were children not in the first group whose weights were below the third centile at 10 and 12 months. Controls were a stratified random sample with weights above the third centile throughout the first year. All children were tested blind at 2 years using the Bayley Scales of Infant Development, adapted for use in Ethiopia. Mean (SD) scores on the psychomotor scale were 10.2 (3.7) in the controls, 6.6 (4.2) in the early growth falterers, and 8.5 (4.3) in the late growth falterers. For the mental scale they were 28.9 (5.8), 22.6 (6.2), and 26.6 (6.1) respectively. Both overall differences were statistically significant at p < .001, and planned comparisons between the control and the combined growth faltering groups, and between the early and later growth faltering groups, showed that each difference was statistically significant for both scales. However, early weight faltering was associated with weight at the time of testing (r = .33), which was associated with scores both on the psychomotor (r = .53) and the mental scale (r = .49). After taking weight at the time of testing into account there was no additional effect attributable to the timing of growth faltering. In this population, therefore, early malnutrition does not have specific adverse effect beyond the contribution that it makes to enduring malnutrition over the first 2 years.

Hematoimmunological profile at gilgel gibe field research center, southwest ethiopia.

Background Health and disease can only be distinguished by accurate and reliable reference values of a particular laboratory test. In interpreting laboratory test results, usually the reported values are compared with established reference values from developed countries. Now it is a fact that there is considerable variation in hematology reference intervals by several variables. However, such data at a population level are scanty in the Ethiopian situation. Therefore, this study was conducted to determine the hematological and immunological values in a community setting. Methods A population-based cross-sectional study was conducted in Gilgel Gibe Field Research Center (GGFRC) from late September 2008 to end of January 2009. A tsample of 1,965 individuals was included in the study. Blood sample was collected by vacutainer tube and transported to Jimma University Specialized Hospital laboratory. Data were entered in to EpiData and analyzed using SPSS for Windows version 16.0 and STATA 11. Results A total of 1965 (955 men and 1010 women) individuals were studied. The mean red blood cell count for men and women was 4.55 × 1012/L and 4.34 × 1012/L (95 percentile range between 2.9 and 5.7 × 1012/L) and 4.34 ×1012/L (95 percentile range between 2.8 and 5.2 × 1012/L), respectively. On the other hand, the red blood cell count of 95% of the men and women lied between 2.9–5.7 × 1012 cells/L and 2.8–5.2 × 1012 cells /L, respectively. The mean hemoglobin value for men was 13.6 gm/dl and for women 12.7 gm/dl. The mean corpuscular volume for men and women was 90.2 fl and 90.8 fl, respectively. The mean platelet value for men was 229.1 ×109 cells/L and for women 241.3 ×109 cells/L. The mean white blood cells count for men and women was 6.08 ×109 cells/L and 6.12 ×109 cells/L, respectively. The mean CD4 value was 809 cell/µl for men and 868 cell /µl for women. Forty two percent of the study participants had O blood group. Conclusion The hematologic and immunologic profile of the studied population in Southwest Ethiopia is different from the reports from other countries and the standards described in western literature. We recommend conducting similar nationwide study to determine the immunological and hematological reference values of the Ethiopian population as a whole.

Malnutrition and mental development: Is there a sensitive period? A nested case-control study

To examine the possibility that there is an early sensitive period for the effects of malnutrition on cognitive development, three groups of children (N = 197) were recruited from a birth cohort with known growth characteristics in south-west Ethiopia (N = 1,563). All had initial weights > or = 2,500 g. Early growth falterers dropped in weight below the third centile (z < -1.88) of the NCHS/WHO reference population in the first 4 months. Late growth falterers were children not in the first group whose weights were below the third centile at 10 and 12 months. Controls were a stratified random sample with weights above the third centile throughout the first year. All children were tested blind at 2 years using the Bayley Scales of Infant Development, adapted for use in Ethiopia. Mean (SD) scores on the psychomotor scale were 10.2 (3.7) in the controls, 6.6 (4.2) in the early growth falterers, and 8.5 (4.3) in the late growth falterers. For the mental scale they were 28.9 (5.8), 22.6 (6.2), and 26.6 (6.1) respectively. Both overall differences were statistically significant at p < .001, and planned comparisons between the control and the combined growth faltering groups, and between the early and later growth faltering groups, showed that each difference was statistically significant for both scales. However, early weight faltering was associated with weight at the time of testing (r = .33), which was associated with scores both on the psychomotor (r = .53) and the mental scale (r = .49). After taking weight at the time of testing into account there was no additional effect attributable to the timing of growth faltering. In this population, therefore, early malnutrition does not have specific adverse effect beyond the contribution that it makes to enduring malnutrition over the first 2 years.

Assessing the goodness-of-fit of the laird and ware model-an example: The Jimma infant survival differential longitudinal study

The Jimma Infant Survival Differential Longitudinal Study is an Ethiopian study, set up to establish risk factors affecting infant survival and to investigate socio-economic, maternal and infant-rearing factors that contribute most to the childs early survival. Here, a subgroup of about 1500 children born in Jimma town is examined for their first years weight gain. Of special interest is the impact of certain cultural practices like uvulectomy, milk teeth extraction and butter swallowing, on childs weight gain; these have never been thoroughly investigated in any study. In this context, the linear mixed model (Laird and Ware) is employed. The purpose of this paper is to illustrate the practical issues when constructing the longitudinal model. Recently developed diagnostics will be used herefor. Finally, special attention will be paid to the two-stage interpretation of the linear mixed model.