Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Makoto Kakinuma.
European Journal of Medicinal Chemistry | 2000
Yoshitsugu Kokuryo; Takuji Nakatani; Makoto Kakinuma; Mikio Kabaki; Kyozo Kawata; Akira Kugimiya; Kenji Kawada; Mitsunobu Matsumoto; Ryuji Suzuki; Mitsuaki Ohtani
Our continuing program to develop new antifolate drugs useful against rheumatoid arthritis led us to modify the pteridine ring of gamma-fluoromethotrexate. Pyrrolopyrimidine derivatives 1e and 1t were found to exhibit potent suppressive effects on the responses of both T and B cells to mitogens, although tetrahydropyridopyrimidine derivatives 2e and 2t and quinazoline derivatives 3e, 3t and 4e showed very weak suppressive activities. Thus, conversion of the pteridine ring of gamma-fluoromethotrexate to a pyrrolopyrimidine ring led to a new potential antirheumatic compound.
Organic Process Research & Development | 2009
Takemasa Hida; Susumu Mitsumori; Tsunetoshi Honma; Yoshiharu Hiramatsu; Hiroshi Hashizume; Tetsuo Okada; Makoto Kakinuma; Kyozo Kawata; Katsuo Oda; Aiko Hasegawa; Toshiaki Masui; Hideo Nogusa
Archive | 2003
Haruo Koike; Katsuo Oda; Yutaka Nishino; Makoto Kakinuma
Organic Process Research & Development | 2010
Takemasa Hida; Junko Kikuchi; Makoto Kakinuma; Hideo Nogusa
Archive | 1999
Tsunetoshi Honma; Yoshiharu Hiramatsu; Tetsuo Okada; Makoto Kakinuma
Archive | 2003
Haruo Koike; Katsuo Oda; Yutaka Nishino; Makoto Kakinuma
Archive | 2002
Toshiaki Masui; Kyozo Kawata; Takayuki Kasai; Makoto Kakinuma
Archive | 2002
Tetsuo Okada; Makoto Kakinuma
Archive | 2001
Yoshiharu Hiramatsu; Tsunetoshi Honma; Makoto Kakinuma; Tetsuo Okada; 哲夫 岡田; 義春 平松; 恒利 本摩; 誠 柿沼
Archive | 1999
Tsunetoshi Honma; Yoshiharu Hiramatsu; Tetsuo Okada; Makoto Kakinuma
