Makoto Takeuchi
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Publication
Featured researches published by Makoto Takeuchi.
Biotechnology Annual Review | 1995
Noboru Inoue; Makoto Takeuchi; Hideya Ohashi; Takamoto Suzuki
Erythropoietin (EPO) is the glycoprotein hormone that promotes differentiation of erythroid progenitor cells in bone marrow. The normal kidney produces EPO to maintain erythrocyte for oxygen supply. This hormone activity was found in the serum of anemic animals in the 1890s. Renal failure results in severe anemia because of reduced EPO production, therefore anemia patients expected EPO treatment for long time. However, this was difficult due to the limited amount of EPO. Many researchers have tried to isolate EPO since the 1950s. Finally Miyake and Goldwasser purified highly active EPO from the urine of aplastic anemia patients. Since then, the characteristics and structural information from the purified material accelerated the cloning of the EPO gene. Mammalian cells were essential to produce EPO, because EPO contains 40% carbohydrate that plays some important roles in its activity, stability and biosynthesis. In 1984, two groups succeeded in cloning the EPO gene and expressing this gene in mammalian cells. Recombinant human EPO is currently available for anemia treatment. In this paper, we review production in mammalian cells, molecular characterization, especially carbohydrate moieties, and clinical applications of recombinant EPO.
Biological & Pharmaceutical Bulletin | 2000
Toshinori Watanabe; Noboru Inoue; Toshiko Kutsukake; Shigeru Matsuki; Makoto Takeuchi
Archive | 1997
Mari Kiban Gijutsu Kenkyusho Minowa; Suguru Oguri; Makoto Takeuchi; Naoyuki Taniguchi; Aruto Yoshida
Archive | 2002
Yasunori Chiba; Yoshifumi Jigami; Hitoshi Sakuraba; Kazuo Kobayashi; Makoto Takeuchi; Yoriko Takeuchi
Archive | 1997
Suguru Oguri; Mari T. Minowa; Aruto Yoshida; Naoyuki Taniguchi; Makoto Takeuchi
Archive | 1999
Kazuhiro Fukuda; Tadashi Makino; Mari T. Minowa; Makoto Takeuchi; Mineko Tanigawa; 正 槇野; 一弘 福田; 誠 竹内; 真理 箕輪; 峰子 谷川
Archive | 1997
Suguru Oguri; Mari T. Minowa; Aruto Yoshida; Naoyuki Taniguchi; Makoto Takeuchi
Archive | 1995
Noboru Inoue; Makoto Takeuchi; Naoyuki Taniguchi; Kazuhisa Tokugawa; 登 井上; 和久 徳川; 誠 竹内; 直之 谷口
Archive | 2001
Aruto Yoshida; Tamao Endo; Hiroshi Manya; Yasunori Chiba; Yoshifumi Jigami; Shigemi Sugioka; Makoto Takeuchi
XXIst International Carbohydrate Symposium 2002 | 2002
Kiyotaka Fujita; Kazuo Kobayashi; Makoto Takeuchi; Hidehiko Kumagai; Kenji Yamamoto
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National Institute of Advanced Industrial Science and Technology
View shared research outputsNational Institute of Advanced Industrial Science and Technology
View shared research outputsNational Institute of Advanced Industrial Science and Technology
View shared research outputs