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Dive into the research topics where Makoto Tanaka is active.

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Featured researches published by Makoto Tanaka.


Journal of Chromatography A | 1998

Novel quartz flow-cell as a post-column photochemical reactor for high-performance liquid chromatography

Makoto Tanaka; Yumi Oshima; Hisao Tsuruta

The construction of a new post-column photochemical reactor with quartz flow cells in series for high-performance liquid chromatography (HPLC) is described. The performance of the new reactor was compared with a conventional open tubular PTFE coil reactor. The sensitivity, accuracy and precision obtained with both reactors are comparable. The new reactor has the obvious advantages of smaller cell volume as well as inertness and resistance to not only light and heat produced by the UV lamp, but also to organic solvents in the mobile phases, which results in greatly improved durability, reduced peak broadening and shorter chromatographic run times. Application of the new reactor to the fluorescence detection of DU-6859a, a new fluoroquinolone antimicrobial agent, in human serum is reported.


Journal of Chromatography A | 1984

Novel ferrocene reagent for pre-column labelling of amines in high-performance liquid chromatography with electrochemical detection

Makoto Tanaka; Kazutake Shimada; Toshio Nambara


Chemical & Pharmaceutical Bulletin | 1979

New Derivatization of Amines for Electrochemical Detection in Liquid Chromatography

Kazutake Shimada; Makoto Tanaka; Toshio Nambara


Molecular Cancer Therapeutics | 2003

A novel low molecular weight antagonist of vascular endothelial growth factor receptor binding: VGA1155

Yasuji Ueda; Takehiro Yamagishi; Kazunori Samata; Hisao Ikeya; Noriko Hirayama; Hajime Takashima; Shiro Nakaike; Makoto Tanaka; Ikuo Saiki


Chemical & Pharmaceutical Bulletin | 1991

Aryloxyacetic acid diuretics with uricosuric activity. II : Substituted [(4-oxo-4H-1-benzopyran-7-yl)oxy]acetic acids and the related compounds

Masayuki Kitagawa; Kenjiro Yamamoto; Shinichi Katakura; Hideyuki Kanno; Koji Yamada; Takayasu Nagahara; Makoto Tanaka


Chemical & Pharmaceutical Bulletin | 1995

Synthesis of Fluorescent 4-Methyl-7-thiocoumaryl S-Glycosides of Sialic Acid

Makoto Tanaka; Toshitsugu Kai; Xue-Long Sun; Hiroaki Takayanagi; Yutaka Uda; Kimio Furuhata


Chemical & Pharmaceutical Bulletin | 1995

Facile Synthesis of 4-Acylamino-2,6-anhydro-2,3,4-trideoxy-D-glycero-D-galacto-non-2-enoic Acids

Xue-Long Sun; Toshitsugu Kai; Makoto Tanaka; Hiroaki Takayanagi; Kimio Furuhata


Chemical & Pharmaceutical Bulletin | 1995

Synthesis of N-Glycolyl-8-O-sulfoneuraminic Acid

Makoto Tanaka; Toshitsugu Kai; Xue-Long Sun; Hiroaki Takayanagi; Kimio Furuhata


Research Communications in Molecular Pathology and Pharmacology | 2002

The topoisomerase II-inhibitor NC-190 reduces the level of thymidine kinase mRNA in murine tumor cells.

Kazunori Samata; Takehiro Yamagishi; Tomotake Ikeda; Aiko Kuraishi; Shiro Nakaike; Makoto Tanaka; Keiko Kashiwagi; Kazuei Igarashi


Chemical & Pharmaceutical Bulletin | 1996

Reaction Products from Fischer's Methylation of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN)

Toshitsugu Kai; Xue-Long Sun; Makoto Tanaka; Hiroaki Takayanagi; Kimio Furuhata

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Xue-Long Sun

Cleveland State University

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Kazunori Samata

Taisho Pharmaceutical Co.

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Shiro Nakaike

Taisho Pharmaceutical Co.

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