Malcolm L. Barnes

Vaginitis in women, diagnosis and treatment

Abstract 1.1. The Trichomonas vaginalis disappeared from the vaginas of 158 women after treatment with metronidazole. Recurrence in 12 cases was thought to represent reinfection.Seventy-five husbands were treated similarly. Of 45 whose semina were cultured, 10 contained the Trichomonas vaginalis.No significant reactions occurred, including in blood studies of 147 individuals. 2.2. Of 478 consecutive cases with vaginal discharge or clinical vaginitis, the causal agent was attributed to Trichomonas vaginalis in 131 (27.4 per cent), Hemophilus vaginalis in 123 (27.4 per cent), Candida albicans in 99 (20.8 per cent), and nonspecific organisms in 125 (26.2 per cent). 3.3. Vaginal discharge and irritation due to Candida albicans and Hemophilus vaginalis represent primarily an infection of the secretions, rather than inflammation of the vaginal wall.

Lymphogranuloma venereum in the female

YMPHOGRANULOMA venereum now L seems to be the acceptabIe name for a disease with so many appelIations as to confuse even workers in the fieId of venerea1 disease. Four years ago we described some urethral Iesions as“Iymphopathia venereum,“l a term originated by WoIf and SuIzberger.” This seemed to be a superior term. However, since the CumuIative Index now Iists this as IymphogranuIoma venereum, the future Iiterature should be correlated under this titIe. Among many other names this disease was caIIed tropical or climatic bubo. The most wideIy known name in recent years has been IymphogranuIoma inguinaIe. It was 0riginaIIy appIied by Durand, NicoIas and Favre3 in 1913 to chronic inguina1 adenitis with muItipIe draining sinuses. The term was applied because of an apparent microscopic simiIarity with Hodgkin’s disease I,,“ Iymphogranuloma “), The study of this condition progressed littIe or none unti1 1923, when Frei4 discovered the diagnostic properties of an antigen prepared from the bacteriologically sterile pus removed from buboes. This important skin test gave impetus to worId wide studies and a tremendous Iiterature has deveIoped. Many obscure Iesions quite unconnected with the inguina1 adenitis have now been brought together. The disease has been transferred to monkeys and to mice (HeIIerstriim and Wass!m,5 and others), producing characteristic meningitis after intracerebrar inocuIation; to guinea pigs (Meyer, RosenfeId and Ander

Stilbestrol treatment of endometriosis; report of a case.

) producing a typica inguina1 adenitis after inocuIation in the groin; and to other animals. The fiIterabIe virus nature of the causative agent has been made cIear by a number of investigators. It has been cultured on tissue-Tyrode media by Tamura.7 The entity of this virus disease is undisputed at the present time.

A Clinicopathologic Study of Ureteropelvic Obstructions

Abstract A single case of pelvic endometriosis with previous conservative surgery and with recurrence of symptoms and palpable nodules in the cul-de-sac was treated with stilbestrol. The drug was given for four months, but was interrupted at the end of two months and at four months because of profuse vaginal bleeding. The dosage began with 1 mg. daily and was increased to 110 mg. daily with the first half of the treatment. It was increased from 1 mg. to 60 mg. daily with the second half. The symptoms and nodular masses in the culde-sac were not improved. Microscopic sections after the second laparotomy showed no atrophic changes in the endometrium or in the endometriosis, but rather the epithelium appeared quite hyperplastic.