Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Malcolm Stuart Nobbs is active.

Publication


Featured researches published by Malcolm Stuart Nobbs.


Bioorganic & Medicinal Chemistry Letters | 1993

Synthesis and pharmacological properties of BW315c and other inotropic 2-arylimidazo[1,2-a]pyrazines

Paul Barraclough; James W. Black; David Cambridge; V. Paul Gerskowitch; Heather Giles; Robert C. Glen; Robert A. D. Hull; W. Richard King; Malcolm Stuart Nobbs; Peter Randall; Gita P. Shah; David Stone; Susan J. Vine; Mark V. Whiting

A series of 2-aryl imidazo[1,2-a]pyrazines has been prepared and evaluated for inotropic activity. Sulphoxide 12, BW315C, displayed potent inotropic effects having comparable in vitro and vivo inotropic potencies to those of isomazole. Structure-activity relationships are discussed.


Journal of Chemical Research-s | 1997

Synthesis of

Paul Barraclough; W. Richard King; Malcolm Stuart Nobbs; Susan J. Vine; Janet M. Gillam

The base-catalysed hydrolysis of oxazolidin-2-one 15 gives an oxypropanolamine 7 and 4,5-dihydro-1H-imidazo[4,5-c]pyridin-4-ones (17–19) and may occur by a B AL mechanism.


Archive | 1989

lsquoA’ Ring IsomazoleOxypropanolamines via Hydrolysis of1H-Imidazo[4,5-c]pyridineOxazolidin-2-ones

Alistair Ainslie Miller; Malcolm Stuart Nobbs; Richard M. Hyde; Michael John Leach


Magnetic Resonance in Chemistry | 1991

Pharmacologically active cns compounds

Paul Barraclough; David Firmin; John C. Lindon; Malcolm Stuart Nobbs; Paul N. Sanderson; Steven Smith; Janet M. Gillam


Archive | 1995

Sites of protonation in cardiotonic polyazaindolizines by NMR spectroscopy

Alistair Ainslie Miller; Malcolm Stuart Nobbs; Richard M. Hyde; Michael John Leach


Magnetic Resonance in Chemistry | 1989

Certain 2,4-diamino-5-(2,3-dihalophenyl)-6-substituted pyrimidines which are pharmacologically active CNS compounds

Paul Barraclough; John C. Lindon; Malcolm Stuart Nobbs; J. M. Williams


Archive | 1995

13C NMR studies of tautomerism in imidazo[4,5-c]pyridines

Alistair Ainslie Miller; Malcolm Stuart Nobbs; Richard Martin Hyde; Michael John Leach


Archive | 1986

Treatment of injury of the spinal cord or brain using 4-amino-2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidine

Paul Barraclough; Steven Smith; Malcolm Stuart Nobbs


Archive | 1998

Aryl derivatives of heterobicyclic compounds.

Brian Cox; Mark Patrick Healy; Malcolm Stuart Nobbs; Gita P. Shah


Archive | 1995

Triazine compounds for treatment of CNS disorders

Alistair Ainslie Miller; Malcolm Stuart Nobbs; Richard Martin Hyde; Michael John Leach

Collaboration


Dive into the Malcolm Stuart Nobbs's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar

Steven Smith

University of California

View shared research outputs
Top Co-Authors

Avatar

Brian Cox

University of Manchester

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge