Malika Berredjem

A simple and eco-sustainable method for the sulfonylation of amines under microwave-assisted solvent-free conditions

A new environmentally benign, simple, and efficient protocol for the chemoselective sulfonylation of various structural amines using microwave irradiation under solvent- and catalyst-free conditions is reported. The corresponding sulfonamides were obtained in excellent yields within short reaction times. Simplicity, milder, cleaner and greener conditions, easier work-up, and lower generation of waste or pollution are the main advantages of this method.

A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions

An efficient and convenient one-pot synthesis of novel α-sulfamidophosphonates is described via a three-component reaction. This reaction was carried out through a three component condensation reaction of sulfonamide, an aromatic aldehyde and triethylphosphite under conventional/ultrasonic techniques, catalyst-free and solvent-free conditions. This methodology was established with many advantages, including mild reaction conditions, short reaction times, good yields, simple work-up procedures, and environmental friendliness.

A simple, rapid, and efficient N-Boc protection of amines under ultrasound irradiation and catalyst-free conditions

Abstract A green and simple approach for the N-Boc protection on structurally diverse amines under ultrasound irradiation is described. Selective N-Boc protection was achieved in excellent isolated yield in a short reaction time at room temperature. Mild conditions, inexpensive and an easily available reagent, and absence of any auxiliary substances are the main advantages of this procedure.Graphical abstract

N‐Chlorosulfonyloxazolidin‐2‐ones: Synthesis, Structure, and Reactivity Toward Aminoesters

Abstract Synthesis, structure, and reactivity of chiral N‐chlorosulfonyloxazolidin‐2‐ones are described. Their synthesis were easily carried out starting from the corresponding chiral oxazolidin‐2‐ones and sulfuryl chloride to afford the title compounds 1 in high yields.

A simple and eco-sustainable method for the O-Boc protection/deprotection of various phenolic structures under water-mediated/catalyst-free conditions

A greener, efficient, and chemoselective protocol for O-Boc protection/deprotection of a wide range of phenol derivatives is reported under catalyst-free conditions in water-related systems. Unlike previous reports, no additional reagents or catalysts were used, and workup fulfils green chemistry requirements, making the present method even more interesting.

Efficient Method for The Synthesis of α-Amidophosphonates via the Michaelis-Arbuzov Reaction

Abstract A new series of modified α-amidophosphonates (or β-ketophosphonate) was synthesized by an efficient method, starting from aminoesters and chloroacetyl chloride. We have established that chloroacetyl chloride is a suitable reagent allowing the introduction a halogen moiety for the Arbuzov reaction. The α-amidophosphonates were prepared in two steps (acetylation, phosphorylation). Supplemental materials are available for this article. Go to the publishers online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. GRAPHICAL ABSTRACT

One-pot synthesis of novel oxazaphosphinanes under ultrasound irradiation and solvent-free conditions

A rapid and efficient solvent-free one-pot synthesis of novel oxazaphosphinane is described under ultrasound irradiation. This reaction was carried out through a three-component condensation reaction of amino alcohol, aromatic aldehyde, and triethyl phosphite. Ultrasonic effects were established with many advantages, including high yields, shorter reaction times, easy and quick isolation of the products. The newly synthesized compounds were systematically characterized by IR, 1H NMR, 13C NMR, 31P NMR, MS, and elemental analysis.Graphical abstract

Cyclosulfamides as Constraint Dipeptides: The Synthesis and Structure of Chiral Substituted 1,2,5-Thiadiazolidine 1,1-Dioxides: Evaluation of the Toxicity

A general synthesis for the preparation of chiral N-N′ substituted 1,2,5-thiadiazolidine 1,1-dioxides has been developed beginning with proteogenic amino acid, sulfuryl chloride, and dibromoethane. The selected chemistry and spectral properties of these compounds are examined. Overall, routes described are applicable to the synthesis of a variety of constrained dipeptidal sulfamides representing novel peptidomimetic scaffolds.

An Efficient Method for the Synthesis of Novel N-acylsulfonamides Using Tin (IV) Chloride as Catalysts

Abstract A series of novel N-acylsulfonamides derivatives were synthesized via direct condensation of parent sulfonamide with ethyl lactate as an acylating agent in the presence of tin (IV) chloride (SnCl4) as a Lewis acid catalyst. The sulfonamides were prepared, starting from chlorosulfonyl isocyanate (CSI), in three steps (carbamoylation, sulfamoylation, and deprotection) with excellent yields. GRAPHICAL ABSTRACT

Efficient Synthesis of Modified Sulfamides and Cyclosulfamides Containing Phosphonate Moieties

Abstract The synthesis of two new series of functionalized phosphonates is described. A new entry for the synthesis of 5-phosphonoalkyl cyclosulfamides and bis(phosphonoalkyl) sulfamides starting from dihalogeno bis(amino) sulfone has been developed. These compounds have been synthesized in good yields. Triethylphosphite has been used to introduce the phosphonate moiety into sulfamides and cyclosulfamides via Arbuzov reaction. GRAPHICAL ABSTRACT