Malin Lundberg Rasmussen
University of Southern Denmark
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Malin Lundberg Rasmussen.
Diabetes | 2014
Rebecca Broe; Malin Lundberg Rasmussen; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Lauren Hodgson; Tien Yin Wong; Tunde Peto; Jakob Grauslund
Diabetic neuropathy, nephropathy, and retinopathy cause significant morbidity in patients with type 1 diabetes, even though improvements in treatment modalities delay the appearance and reduce the severity of these complications. To prevent or further delay the onset, it is necessary to better understand common underlying pathogenesis and to discover preclinical biomarkers of these complications. Retinal vessel calibers have been associated with the presence of microvascular complications, but their long-term predictive value has only been sparsely investigated. We examined retinal vessel calibers as 16-year predictors of diabetic nephropathy, neuropathy, and proliferative retinopathy in a young population-based Danish cohort with type 1 diabetes. We used semiautomated computer software to analyze vessel diameters on baseline retinal photos. Calibers of all vessels coursing through a zone 0.5–1 disc diameter from the disc margin were measured and summarized as the central artery and vein equivalents. In multiple regression analyses, we found wider venular diameters and smaller arteriolar diameters were both predictive of the 16-year development of nephropathy, neuropathy, and proliferative retinopathy. Early retinal vessel caliber changes are seemingly early markers of microvascular processes, precede the development of microvascular complications, and are a potential noninvasive predictive test on future risk of diabetic retinopathy, neuropathy, and nephropathy.
Journal of Diabetes and Its Complications | 2015
Malin Lundberg Rasmussen; Rebecca Broe; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Tunde Peto; Jakob Grauslund
AIMS To compare non-mydriatic, mydriatic and steered mydriatic widefield retinal images with mydriatic 7-field Early Treatment Diabetic Retinopathy Study (ETDRS)-standards in grading diabetic retinopathy (DR). METHODS We examined 95 patients (190 eyes) with type 1 diabetes. A non-mydriatic, a mydriatic and four steered mydriatic 200° widefield retinal images were captured (Optos 200Tx, Optos plc, Dunfermline, Scotland) and compared to mydriatic 7-field 45° ETDRS images (Topcon 3D OCT-2000, Topcon, Tokyo, Japan). Images were graded for DR according to ETDRS-protocol by a trained and certified grader masked to the results of the corresponding grading. For agreement kappa-statistics were used. RESULTS Exact level agreement with 7-field images was found in 76.3%, 76.1% and 70.7% for non-mydriatic, mydriatic and steered mydriatic widefield images, respectively. Corresponding values for one-level agreement were 99.0%, 98.9% and 99.5%, respectively. Non-mydriatic matched mydriatic widefield images almost fully with exact and one-level agreement of 96.8% and 100.0%, respectively. Mydriatic steered images resulted in higher grading in 24 eyes. CONCLUSIONS Widefield images matched 7-field images favorably. Widefield images can be captured without pupil-dilation and only one image is needed. However, because of overlapping eyelashes and distortion some lesion might be missed. Mydriatic steered images in selected cases may solve some of these problems.
Diabetic Medicine | 2017
K Sandahl; Lotte B. Nielsen; Jannet Svensson; Jesper Johannesen; Flemming Pociot; Henrik B. Mortensen; Philip Hougaard; Rebecca Broe; Malin Lundberg Rasmussen; Jakob Grauslund; Tunde Peto; Birthe S. Olsen
To determine the mortality rate in a Danish cohort of children and adolescents diagnosed with Type 1 diabetes mellitus compared with the general population.
Diabetic Medicine | 2015
Rebecca Broe; Malin Lundberg Rasmussen; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Tunde Peto; Jakob Grauslund
To examine the long‐term incidence of vitrectomy in young people with Type 1 diabetes.
Experimental Diabetes Research | 2017
Søren Leer Blindbæk; Thomas Lee Torp; Kristian Lundberg; Kerstin Soelberg; Anna Stage Vergmann; Christina Døfler Poulsen; Ulrik Frydkjaer-Olsen; Rebecca Broe; Malin Lundberg Rasmussen; Jimmi Wied; Majbrit Lind; Anders Højslet Vestergaard; Tunde Peto; Jakob Grauslund
The retinal vascular system is the only part of the human body available for direct, in vivo inspection. Noninvasive retinal markers are important to identity patients in risk of sight-threatening diabetic retinopathy. Studies have correlated structural features like retinal vascular caliber and fractals with micro- and macrovascular dysfunction in diabetes. Likewise, the retinal metabolism can be evaluated by retinal oximetry, and higher retinal venular oxygen saturation has been demonstrated in patients with diabetic retinopathy. So far, most studies have been cross-sectional, but these can only disclose associations and are not able to separate cause from effect or to establish the predictive value of retinal vascular dysfunction with respect to long-term complications. Likewise, retinal markers have not been investigated as markers of treatment outcome in patients with proliferative diabetic retinopathy and diabetic macular edema. The Department of Ophthalmology at Odense University Hospital, Denmark, has a strong tradition of studying the retinal microvasculature in diabetic retinopathy. In the present paper, we demonstrate the importance of the retinal vasculature not only as predictors of long-term microvasculopathy but also as markers of treatment outcome in sight-threatening diabetic retinopathy in well-established population-based cohorts of patients with diabetes.
European Journal of Ophthalmology | 2015
Malin Lundberg Rasmussen; Rebecca Broe; Ulrik Frydkjaer-Olsen; Tunde Peto; Jakob Grauslund
Abstracts from the 25th Meeting of the European Association for the Study of Diabetes Eye Complications Study Group (EASDec). Turin, Italy - June 26-28, 2015.
Diabetologia | 2014
Rebecca Broe; Malin Lundberg Rasmussen; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Tunde Peto; Jakob Grauslund
Acta Diabetologica | 2014
Rebecca Broe; Malin Lundberg Rasmussen; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik Bindesboel Mortensen; Tunde Peto; Jakob Grauslund
Graefes Archive for Clinical and Experimental Ophthalmology | 2015
Malin Lundberg Rasmussen; Rebecca Broe; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Tunde Peto; Jakob Grauslund
Graefes Archive for Clinical and Experimental Ophthalmology | 2017
Malin Lundberg Rasmussen; Rebecca Broe; Ulrik Frydkjaer-Olsen; Birthe S. Olsen; Henrik B. Mortensen; Tunde Peto; Jakob Grauslund