Mamoru Machino | Researchain

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Featured researches published by Mamoru Machino.

International Scholarly Research Notices | 2012

Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin

Yukio Murakami; Mamoru Machino; Seiichiro Fujisawa

Porphyromonas gingivalis (Pg) fimbriae, in addition to lipopolysaccharide, are involved in the pathogenesis of periodontal disease. At the same time, bioactive compounds such as fibronectin (FN) and melatonin in saliva and gingival crevicular fluid have been reported to exert a preventive effect against periodontitis. Here, we review current knowledge regarding the potent inhibitory effects of FN and melatonin against Pg fimbria-induced induction of proinflammatory cytokines, cyclooxygenase-2 (COX-2) expression, and NF-kappa B activation in mouse macrophages and discuss their possible clinical application for prevention of periodontal diseases induced by oral bacteria.

Anticancer Research | 2007

Re-evaluation of Cyclooxygenase-2-inhibiting Activity of Vanillin and Guaiacol in Macrophages Stimulated with Lipopolysaccharide

Yukio Murakami; Atsushi Hirata; Shigeru Ito; Masao Shoji; Shoji Tanaka; Toshikazu Yasui; Mamoru Machino; Seiichiro Fujisawa

in Vivo | 2010

Multiple Biological Complex of Alkaline Extract of the Leaves of Sasa senanensis Rehder

Hiroshi Sakagami; Li Zhou; Michiyo Kawano; May Maw Thet; Shoji Tanaka; Mamoru Machino; Shigeru Amano; Reina Kuroshita; Shigeru Watanabe; Qing Chu; Qintao Wang; Taisei Kanamoto; Shigemi Terakubo; Hideki Nakashima; Keisuke Sekine; Yoshiaki Shirataki; Chang-Hao Zhang; Yoshihiro Uesawa; Kiminori Mohri; Madoka Kitajima; Hiroshi Oizumi; Takaaki Oizumi

Anticancer Research | 2008

Comparative anti-inflammatory activities of curcumin and tetrahydrocurcumin based on the phenolic O-H bond dissociation enthalpy, ionization potential and quantum chemical descriptor.

Yukio Murakami; Hiroaki Ishii; Naoki Takada; Shoji Tanaka; Mamoru Machino; Shigeru Ito; Seiichiro Fujisawa

Journal of Clinical Pediatric Dentistry | 2008

The relationship of Prevotella intermedia, Prevotella nigrescens and Prevotella melaninogenica in the supragingival plaque of children, caries and oral malodor.

Shoji Tanaka; Mikako Yoshida; Yukio Murakami; Takako Ogiwara; Masao Shoji; Satoko Kobayashi; Sigeru Watanabe; Mamoru Machino; Seiichiro Fujisawa

in Vivo | 2011

Effect of Melatonin on Cyclooxygenase-2 Expression and Nuclear Factor-Kappa B Activation in RAW264.7 Macrophage-like Cells Stimulated with Fimbriae of Porphyromonas gingivalis

Yukio Murakami; Kenji Yuhara; Naoki Takada; Tomoe Arai; Seiko Tsuda; Sayako Takamatsu; Mamoru Machino; Seiichiro Fujisawa

Anticancer Research | 2000

Induction of apoptosis by dopamine in human oral tumor cell lines.

Hiroshi Terasaka; Tamura A; Fumitoshi Takayama; Kashimata M; Ohtomo K; Mamoru Machino; Seiichiro Fujisawa; Toguchi M; Yumiko Kanda; Shiro Kunii; Kaoru Kusama; Ishino A; Shigeru Watanabe; Satoh K; Takano H; Takahama M; Hiroshi Sakagami

in Vivo | 2013