Manami Suzuki

Relationship Between Toll-like Receptor-4 and mPGES-1 Gene Expression in Local Lesions of Endometriosis Patients

Toll‐like receptors (TLRs) are innate immune receptors that mediate the pattern recognition of, and response toward, pathogens and host‐derived danger signals. We reported that cyclooxygenase‐2 (COX‐2) and microsomal prostaglandin E synthase (mPGES) mRNA were expressed in cases of endometriosis. The relationship between COX‐2, mPGES‐1, and TLR4 in endometriotic lesions has yet to be determined.

Effect on the production of soluble endoglin from human choriocarcinoma cells by preeclampsia sera.

Citation Aoki Y, Yamamoto T, Fumihisa C, Nakamura A, Asanuma A, Suzuki M. Effect on the production of soluble endoglin from human choriocarcinoma cells by preeclampsia sera. Am J Reprod Immunol 2012; 67: 413–420

Effects of anti-β2-glycoprotein I antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cell line.

Aim:  Anti‐β2‐glycoprotein I (anti‐β2‐GPI) antibody has been detected in cases of recurrent abortion and intrauterine death. Placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) are growth factors that accelerate villous proliferation. Soluble VEGF receptor‐1 (sVEGFR1) is a soluble receptor for PlGF and suppresses the function of PlGF. In order to study the pathological mechanism of anti‐β2‐GPI antibody, we evaluated the effects of anti‐β2‐GPI antibody on PlGF, VEGF and sVEGFR1 production from cultured choriocarcinoma cells.

Autoantibodies isolated from patients with preeclampsia induce soluble endoglin production from trophoblast cells via interactions with angiotensin II type 1 receptor.

This study investigated whether angiotensin II type 1 receptor agonistic autoantibodies (AT1‐AAs) mediate the increased release of soluble endoglin (sEng) in women with preeclampsia.

Expression of placenta growth factor, soluble fms-like tyrosine kinase-1, metal-responsive transcription factor-1, heme oxygenase 1 and hypoxia inducible factor-1α mRNAs in pre-eclampsia placenta and the effect of pre-eclampsia sera on their expression of choriocarcinoma cells

We studied the effect of pre‐eclampsia sera on the expression of placenta growth factor (PlGF), soluble fms‐like tyrosine kinase‐1 (sFlt‐1), metal‐responsive transcription factor‐1 (MTF‐1), heme oxygenase 1 (HO‐1) and hypoxia inducible factor‐1α (HIF‐1α) mRNAs in JEG‐3 cells (trophoblast‐derived cells) and placenta from pre‐eclampsia patients to investigate pre‐eclampsia pathophysiology.